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- Pharmacology For Phenylephrine + Chlorpheniramine maleate + Boric acid
Phenylephrine + Chlorpheniramine maleate + Boric acid Pharmacology
Phenylephrine + Chlorpheniramine maleate + Boric acid
About Phenylephrine + Chlorpheniramine maleate + Boric acidN/AMechanism of Action of Phenylephrine + Chlorpheniramine maleate + Boric acidN/APharmacokinets of Phenylephrine + Chlorpheniramine maleate + Boric acidN/AOnset of Action for Phenylephrine + Chlorpheniramine maleate + Boric acidN/ADuration of Action for Phenylephrine + Chlorpheniramine maleate + Boric acidN/AHalf Life of Phenylephrine + Chlorpheniramine maleate + Boric acidN/ASide Effects of Phenylephrine + Chlorpheniramine maleate + Boric acidN/AContra-indications of Phenylephrine + Chlorpheniramine maleate + Boric acidN/ASpecial Precautions while taking Phenylephrine + Chlorpheniramine maleate + Boric acidN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Phenylephrine + Chlorpheniramine maleate + Boric acidN/AInteractions for Phenylephrine + Chlorpheniramine maleate + Boric acidN/ATypical Dosage for Phenylephrine + Chlorpheniramine maleate + Boric acidN/ASchedule of Phenylephrine + Chlorpheniramine maleate + Boric acidN/AStorage Requirements for Phenylephrine + Chlorpheniramine maleate + Boric acidN/AEffects of Missed Dosage of Phenylephrine + Chlorpheniramine maleate + Boric acidN/AEffects of Overdose of Phenylephrine + Chlorpheniramine maleate + Boric acidN/APhenylephrine
About PhenylephrineAn a1-adrenergic receptor agonist, Phenethylamine derivative, Decongestant, Antiglaucoma, Mydriatic.Mechanism of Action of PhenylephrineThe drug exerts it`s pharmacological action by acting as a selective alpha-1 adrenergic agonist. It causes vasoconstriction and increases total peripheral resistance and raises blood pressure. It reduces intraocular tension by constricting ciliary body blood vessels and produce mydriasis (without cycloplegia). It exerts nasal decongestant action; by vasoconstrictory action on arterioles of nasal mucosa. It prolongs and localizes the action of anaesthetics due to it`s vasoconstrictory action on skin, mucous membrane, and viscera and thus slows the rate of absorption of local anaesthetics.Pharmacokinets of PhenylephrineAbsorption: Variable depending up on the route of administration. Metabolism: Metabolized in the liver and intestine.Onset of Action for PhenylephrineNasal: Rapid
Ophthalmic: Rapid
I.V.: Rapid
I.M.: Within 15 minutes
Duration of Action for PhenylephrineNasal: ? to 4 hours
Ophthalmic: 3 to 7 hours
I.V.: 15 to 20 minutes
I.M.: ? to 2 hours.
Half Life of PhenylephrineN/ASide Effects of Phenylephrine1.Bradycardia
2.Arrhythmias
3.Hypertension
4.Tachycardia
5.Palpitations
6.Premature ventricular contractions
7.Pallor
8.Headache
9.Dizziness
10.Nervousness
11.Brow ache(with ophthalmic form)
12.Burning or stinging in eye
13.Blurred vision
14.Elevated intraocular pressure
15.Nausea
16.Episodes of asthma
17.Tachyphylaxis
18.Anaphylaxis
Contra-indications of Phenylephrine1.Hypersensitivity to the drug
2.Hyperthyroidism
3.Ventricular tachycardia and severe hypertension (Injected form)
4.Angle closure glaucoma and in those who wear soft contact lenses(ophthalmic form)
Special Precautions while taking Phenylephrine1.Coronary diseases
2.Advanced arteriosclerosis
3.Bradycardia
4.Partial heart block
5.Myocardial diseases
6.Atherosclerosis
7.Hypertension
8.Nasal and ophthalmic form use cautiously in type-1 diabetes mellitus
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below age 6:contraindicatedIndications for Phenylephrine1.Hypotension
2.Paroxysmal supra ventricular tachycardia
3.Maintain blood pressure during spinal and inhalation anaesthesia
4.Prolongation of spinal anaesthesia
5.Shock
6.Mydriasis(without cycloplegia)
7.Nasal congestion.
8.Cataract
Interactions for PhenylephrineMay interact with systemically administered MAOIs.Typical Dosage for PhenylephrineI.M. or S.C.: 2 to 5mg. Then if required; give doses up to 10mg.
Slow I.V. injection: 0.1 to 0.5mg. Then if required; repeat after 15 minutes.
I.V. infusion: Starts with 0.18mg/minute. Then adjust the dosage up to 0.03 to 0.06mg/minute based on patient`s response.
Nasal congestion: Apply 2 to 3 drops or 1 to 2 sprays of 0.25% to 1% solution instilled in each nostril.
Mydriasis (without cycloplegia): Instill 1 to 2drops 2.5% or 10% solution in eye. Repeated if required.
Prolongation of spinal anaesthesia: 2 to 5mg added to anaesthetic solution.
Schedule of PhenylephrineN/AStorage Requirements for PhenylephrineStore at controlled room temperature at range of 15 to 30 degree C. in a well closed container. Protect from light.Effects of Missed Dosage of PhenylephrineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of PhenylephrineDiscontinue the drug and give supportive and symptomatic treatment. Closely monitor vital signs. Use atropine sulfate to block reflex Bradycardia. Treat excessive hypertension with phentolamine. Treat cardiac arrhythmia with propranolol. Treat excessive mydriatic effect with levodopa.
Chlorpheniramine Maleate
About Chlorpheniramine MaleateN/AMechanism of Action of Chlorpheniramine MaleateN/APharmacokinets of Chlorpheniramine MaleateN/AOnset of Action for Chlorpheniramine MaleateN/ADuration of Action for Chlorpheniramine MaleateN/AHalf Life of Chlorpheniramine MaleateN/ASide Effects of Chlorpheniramine MaleateN/AContra-indications of Chlorpheniramine MaleateFirst Generation alkylamine H1 Antagonist, Antihistamine.Special Precautions while taking Chlorpheniramine MaleateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Chlorpheniramine MaleateN/AInteractions for Chlorpheniramine MaleateN/ATypical Dosage for Chlorpheniramine MaleateN/ASchedule of Chlorpheniramine MaleateN/AStorage Requirements for Chlorpheniramine MaleateN/AEffects of Missed Dosage of Chlorpheniramine MaleateN/AEffects of Overdose of Chlorpheniramine MaleateN/ABoric acid
About Boric acidA weak acid, as mild antibiotic against fungal or bacterial infection, An eye wash to cleanse or irrigate the eyes, antiseptic and emulsifier.Mechanism of Action of Boric acidN/APharmacokinets of Boric acidN/AOnset of Action for Boric acidN/ADuration of Action for Boric acidN/AHalf Life of Boric acidN/ASide Effects of Boric acid1.Decreased vision
2.Redness of the eye
Contra-indications of Boric acid1.Hypersensitivity to Boric acidSpecial Precautions while taking Boric acid1.Hypertension
2.Blood vessel disease
3.Allergic to any medicine
4.Contact lenses
5.Open sores in or near the eyes
6.Do not use on damaged or broken skinPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below 3 years:ContraindicatedIndications for Boric acid1.As an irrigation solution to cleanse and treat irritated eyesInteractions for Boric acidN/ATypical Dosage for Boric acidAs directed by the physician
Apply boric acid eye solution with the aid of an eyecup. Fill the eyecup halfway with the solution, press tightly to the wide open eye, and tilt head back. Move the eyeball around to ensure full contact with the solution. Avoid contamination of the rim and inside of the eyecup by rinsing it with clean water immediately before and after each use. Schedule of Boric acidN/AStorage Requirements for Boric acidStore medicine away from heat and direct light. Keep out of the reach of children.Effects of Missed Dosage of Boric acidIt is usually only used when needed for irritated eyes. Missing a dose is usually not harmful.Effects of Overdose of Boric acidGive supportive measures and symptomatic treatment.Home Delivery for Phenylephrine + Chlorpheniramine maleate + Boric acid in Your City
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