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- Pharmacology For Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops)
Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops) Pharmacology
Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops)
About Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops)N/AMechanism of Action of Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops)N/APharmacokinets of Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops)N/AOnset of Action for Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops)N/ADuration of Action for Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops)N/AHalf Life of Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops)N/ASide Effects of Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops)N/AContra-indications of Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops)N/ASpecial Precautions while taking Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops)N/APregnancy Related InformationContraindicated;since Betamethasone and Chloramphenicol are contraindicated in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated;since Betamethasone and Chloramphenicol are contraindicated in breast feeding.Children Related InformationN/AIndications for Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops)It is a combination of corticosteroid Betamethasone and antibacterial Chloramphenicol.
1.Infections of ear / eye
Interactions for Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops)N/ATypical Dosage for Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops)Instill 1 - 2 drop to the affected ear / eye 1- 3 times dailySchedule of Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops)N/AStorage Requirements for Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops)N/AEffects of Missed Dosage of Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops)N/AEffects of Overdose of Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops)N/ABetamethasone (Eye/Ear)
About Betamethasone (Eye/Ear)Potent glucocorticoid, Anti-inflammatory.Mechanism of Action of Betamethasone (Eye/Ear)
The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Betamethasone (Eye/Ear)Absorption:It is administered as eye dropOnset of Action for Betamethasone (Eye/Ear)N/ADuration of Action for Betamethasone (Eye/Ear)N/AHalf Life of Betamethasone (Eye/Ear)N/ASide Effects of Betamethasone (Eye/Ear)1.Itching
2.Blurred vision
3.Burning sensation
4.Eye irritation
5.Allergic dermatitis
6.Increased pressure within the eye
7.Stinging
Contra-indications of Betamethasone (Eye/Ear)1.Eye conditions producing pus
2.Fungal infections of the eye
3.Glaucoma
4.Herpetic keratitis
5.Tuberculosis infection affecting the eye
6.Viral infections of the eye
Special Precautions while taking Betamethasone (Eye/Ear)Prolonged usePregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationUse with cautionIndications for Betamethasone (Eye/Ear)1.Inflammation of the eyeInteractions for Betamethasone (Eye/Ear)N/ATypical Dosage for Betamethasone (Eye/Ear)Adult:Apply the eye drop every 1-2 hours until controlled and then reduce the frequency 2 - 4 times daily. Schedule of Betamethasone (Eye/Ear)N/AStorage Requirements for Betamethasone (Eye/Ear)Store in a cool, dry place. Protect from direct light and heat. Discard this preparation one month after opening. Keep out of reach of childrenEffects of Missed Dosage of Betamethasone (Eye/Ear)Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Betamethasone (Eye/Ear)Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutesChloramphenicol (Eye/Ear Drops)
About Chloramphenicol (Eye/Ear Drops)Bacteriostatic broad-spectrum antibiotic, ophthalmic antibacterial agent for ocular infections.Mechanism of Action of Chloramphenicol (Eye/Ear Drops)Chloramphenicol is a broad spectrum antibiotic which is primarily bacteriostatic at low concentration and exerts bactericidal action at higher concentration. It acts by inhibiting bacterial protein synthesis. Chloramphenicol attaches to 50S subunit of ribosome and interfering with transfer of elongating peptide chain to the newly attached aminoacyl-tRNA at the ribosome-m RNA complex. It prevents the access of aminoacyl-tRNA to the acceptor site for amino acid incorporation. By acting as a peptide analogue it inhibits peptide bond formation.
Chloramphenicol eye/ear drops or eye ointment which are applied to the eye/ear directly act on the bacteria which produces infection.
Pharmacokinets of Chloramphenicol (Eye/Ear Drops)Absorption: Only a very small amount of the drug enters in to the systemic circulation:Onset of Action for Chloramphenicol (Eye/Ear Drops)N/ADuration of Action for Chloramphenicol (Eye/Ear Drops)N/AHalf Life of Chloramphenicol (Eye/Ear Drops)N/ASide Effects of Chloramphenicol (Eye/Ear Drops)1.Burning
2.Stinging
3.Hypersensitivity reactions( Anaphylaxis, Angioneurotic edema, Urticaria, Fever, Vesicular and maculopapular dermatitis)Contra-indications of Chloramphenicol (Eye/Ear Drops)1.Hypersensitivity to Chloramphenicol
2.Myelosuppression during previous exposure to Chloramphenicol
3.Blood dyscrasias
4.Perforated ear drum (ear drops)Special Precautions while taking Chloramphenicol (Eye/Ear Drops)1.Prolonged use
2.If irritation occurs then discontinue the use of medicaments
3.Avoid contact lenses
4.Avoid driving vehicle or operating machine since Chloramphenicol eye drops produces blurred vision
5.If you are using more than one type of eye drop you should administer them at least five minutes apart, to prevent the second drop washing away the first. Use eye gels or ointments lastPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
CHILDREN below 2 years: contraindicatedIndications for Chloramphenicol (Eye/Ear Drops)EYE DROPS:
1.Bacterial conjunctivitis
2.Corneal ulcers
3.Trachoma
4.Ocular infections
EAR DROPS:
1.Bacterial Otitis externa
2.Chronic Otitis media
3.Pre and post aural or mastoid surgery
Interactions for Chloramphenicol (Eye/Ear Drops)N/ATypical Dosage for Chloramphenicol (Eye/Ear Drops)Chloramphenicol eye drops 0.4%, 0.5% and 1% and eye ointments 1% w/v is available.
Eyes: 1 drop should be instilled in the infected eye every 2 hours for 2 days and thereafter every 4 hours for up to 5 days. Do not use during sleep.
Chloramphenicol 5% w/v drop is used
Ears: The area should be cleaned and 2 - 3 drops instilled in the infected ear 3 - 4 times a day for up to 1 week
Children: 1 - 2 drops 3 times daily.
Schedule of Chloramphenicol (Eye/Ear Drops)N/AStorage Requirements for Chloramphenicol (Eye/Ear Drops)Stored in a refrigerator at 2? to 8?C.Protect from heat and light. Opened eye drops should be discarded after 5 days. Keep out of the reach of childrenEffects of Missed Dosage of Chloramphenicol (Eye/Ear Drops)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Chloramphenicol (Eye/Ear Drops)Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes. Home Delivery for Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops) in Your City
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Betamethasone (Eye/Ear)+ Chloramphenicol (Eye/Ear Drops) is a generic medicine name and there are several brands available for it. Some of the brands for betamethasone (eye/ear)+ chloramphenicol (eye/ear drops) might be better known than betamethasone (eye/ear)+ chloramphenicol (eye/ear drops) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have betamethasone (eye/ear)+ chloramphenicol (eye/ear drops) in stock, you can ask for one of the branded alternatives for betamethasone (eye/ear)+ chloramphenicol (eye/ear drops).