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- Pharmacology For Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.)
Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.) Pharmacology
Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.)
About Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.)N/AMechanism of Action of Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.)N/APharmacokinets of Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.)N/AOnset of Action for Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.)N/ADuration of Action for Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.)N/AHalf Life of Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.)N/ASide Effects of Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.)N/AContra-indications of Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.)N/ASpecial Precautions while taking Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.)N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.)N/AInteractions for Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.)N/ATypical Dosage for Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.)N/ASchedule of Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.)N/AStorage Requirements for Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.)N/AEffects of Missed Dosage of Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.)N/AEffects of Overdose of Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.)N/AOfloxacin (Eye Prep.)
About Ofloxacin (Eye Prep.)A second generation fluoroquinolone(quinolones), Ophthalmic Antibiotic.Mechanism of Action of Ofloxacin (Eye Prep.)Ofloxacin is a bactericidal drug. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Ofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.Pharmacokinets of Ofloxacin (Eye Prep.)Absorption: Absorption after ophthalmic application is minimal.Onset of Action for Ofloxacin (Eye Prep.)N/ADuration of Action for Ofloxacin (Eye Prep.)N/AHalf Life of Ofloxacin (Eye Prep.)N/ASide Effects of Ofloxacin (Eye Prep.)1. Burning
2. Irritation
3. Itching
4. Bitter taste
5. Redness
6. Swelling
7. Blurred vision
8. Increased sensitivity of the eyes to light
9. Blistering
10. Swelling
11.Pain
Contra-indications of Ofloxacin (Eye Prep.)1. Hypersensitivity to Ofloxacin and other FluoroquinolonesSpecial Precautions while taking Ofloxacin (Eye Prep.)1. Prolonged use
2. If irritation occurs then discontinue the use of medicaments
3. Avoid contact lenses
4. Wear sun glasses if sensitivity to sunlight occurs
5. Avoid driving vehicle, operating machine since it produces blurred vision
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicated
NEONATES : ContraindicatedIndications for Ofloxacin (Eye Prep.)1. Conjunctivitis
2. Corneal ulcers
3. Keratitis
4. Blepharitis
5. Dacrocystitis
6. Trachoma
7. Keratoconjunctivitis
8. Prophylaxis of ocular infections
Interactions for Ofloxacin (Eye Prep.)N/ATypical Dosage for Ofloxacin (Eye Prep.)Ofloxacin 0.3 %w/v drops and ointments are available.
Eye drops: 1-2 drops 6 times daily.
Severe infections: 2 drops should be applied to every hour.
Eye ointment: Apply ? inch ribbon 6 - 8 times daily and then reduce the dose depending on infection
Schedule of Ofloxacin (Eye Prep.)N/AStorage Requirements for Ofloxacin (Eye Prep.)Store at cool dry place. Protect from light. Do not freeze. Keep out of the reach of children. Avoid use of medicament 1 month after opening.Effects of Missed Dosage of Ofloxacin (Eye Prep.)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Ofloxacin (Eye Prep.)Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes. Prednisolone (Eye Pre.)
About Prednisolone (Eye Pre.)Ophthalmic synthetic Glucocorticoid, Ophthalmic anti-inflammatory.Mechanism of Action of Prednisolone (Eye Pre.)The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts more selective glucocorticoid action with little mineralocorticoid actions.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction. Prednisolone acetate 1% ophthalmic solution is used for inflammation of eye. Prednisolone acetate is 3 to 5 times more active than Hydrocortisone.
Pharmacokinets of Prednisolone (Eye Pre.)Absorption: It is absorbed after instilled into the eye.Onset of Action for Prednisolone (Eye Pre.)N/ADuration of Action for Prednisolone (Eye Pre.)N/AHalf Life of Prednisolone (Eye Pre.)N/ASide Effects of Prednisolone (Eye Pre.)1.Transient burning
2.Stinging
3.Ocular irritation
4.Blurred vision
5.Allergic reactions
Contra-indications of Prednisolone (Eye Pre.)1.Hypersensitivity to Prednisolone eye preparations
2.Epithelial herpes simplex keratitis
3.Bacterial and fungal infection of the eye
Special Precautions while taking Prednisolone (Eye Pre.)1.Prolonged use
2.Cataract
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicatedIndications for Prednisolone (Eye Pre.)Inflammation of eyeInteractions for Prednisolone (Eye Pre.)N/ATypical Dosage for Prednisolone (Eye Pre.)Instil 1-2 drops into the affected eye 2-4 times daily. Schedule of Prednisolone (Eye Pre.)N/AStorage Requirements for Prednisolone (Eye Pre.)Store in a cool place. Protect from light. Keep out of the reach of children.Effects of Missed Dosage of Prednisolone (Eye Pre.)Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Prednisolone (Eye Pre.)Give supportive measures and symptomatic treatment.Home Delivery for Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.) in Your City
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Ofloxacin (Eye Prep.) + Prednisolone (Eye Pre.) is a generic medicine name and there are several brands available for it. Some of the brands for ofloxacin (eye prep.) + prednisolone (eye pre.) might be better known than ofloxacin (eye prep.) + prednisolone (eye pre.) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ofloxacin (eye prep.) + prednisolone (eye pre.) in stock, you can ask for one of the branded alternatives for ofloxacin (eye prep.) + prednisolone (eye pre.).