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- Pharmacology For Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.)
Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.) Pharmacology
Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.)
About Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.)N/AMechanism of Action of Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.)N/APharmacokinets of Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.)N/AOnset of Action for Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.)N/ADuration of Action for Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.)N/AHalf Life of Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.)N/ASide Effects of Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.)N/AContra-indications of Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.)N/ASpecial Precautions while taking Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.)N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.)N/AInteractions for Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.)N/ATypical Dosage for Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.)N/ASchedule of Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.)N/AStorage Requirements for Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.)N/AEffects of Missed Dosage of Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.)N/AEffects of Overdose of Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.)N/AFluorometholone (Eye.Prep.)
About Fluorometholone (Eye.Prep.)A Synthetic Glucocorticoid, In steroid responsive inflammations of Eye( topical anti-inflammatory).Mechanism of Action of Fluorometholone (Eye.Prep.)The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Fluorometholone (Eye.Prep.)N/AOnset of Action for Fluorometholone (Eye.Prep.)N/ADuration of Action for Fluorometholone (Eye.Prep.)N/AHalf Life of Fluorometholone (Eye.Prep.)N/ASide Effects of Fluorometholone (Eye.Prep.)1.Elevation of intraocular pressure
2.Optic nerve damage
3.Posterior subcapsular cataract formation
4.Delayed wound healing
5.Acute anterior uveitis
6.Keratitis
7.Conjunctivitis
8.Corneal ulcers
9.Mydriasis
10.Conjunctival hyperemia
11.Loss of accommodation
12.Ptosis
13.Transient burning
14.Stinging
15.Ocular irritation
16.Taste perversion
17.Blurred visionContra-indications of Fluorometholone (Eye.Prep.)1.Hypersensitivity to Fluorometholone
2.Viral and fungal disease of the eye
Special Precautions while taking Fluorometholone (Eye.Prep.)1.Glaucoma
2.Regular monitoring of intraocular pressure should be required
3.Cataract surgery may delay healing
4.Patient wearing contact lenses
Pregnancy Related InformationContraindicatedOld Age Related InformationContraindicatedBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below 2 years: Contraindicated
Indications for Fluorometholone (Eye.Prep.)Corticosteroid responsive inflammation of eyeInteractions for Fluorometholone (Eye.Prep.)N/ATypical Dosage for Fluorometholone (Eye.Prep.)Instill one drop 2 - 4 times daily. If signs and symptoms fail to improve after two days, the patient should be re-evaluated. The drug should be withdraw gradually.Schedule of Fluorometholone (Eye.Prep.)N/AStorage Requirements for Fluorometholone (Eye.Prep.)Store at room temperature at 15 - 30 degree Celsius. Avoid freezing. Shake well before use. Keep out of the reach of children.Effects of Missed Dosage of Fluorometholone (Eye.Prep.)Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule.Effects of Overdose of Fluorometholone (Eye.Prep.)Give supportive measures and symptomatic treatment.Tobramycin (Eye Prep.)
About Tobramycin (Eye Prep.)Aminoglycoside derivative, Ophthalmic Antibiotic.Mechanism of Action of Tobramycin (Eye Prep.)Tobramycin is a water soluble amino glycoside antibiotic active against a variety of ophthalmic bacterial pathogens.Tobramycin exerts its bactericidal action against gram- negative organisms & some of gram positive organisms by inhibiting bacterial protein synthesis. The process involves 1.Penetration of bacterial cell membrane & binding directly to the bacterial ribosome, 2.Misleading of m-RNA codon by bacterial ribosome, 3.Formation of peptide chains with wrong amino acid sequence which gets incorporated into bacterial cell membrane and alters its permeability, 4.Bacterial cell lysis. Some bacterial strains like pseudomonas are more sensitive to Tobramycin than GentamicinPharmacokinets of Tobramycin (Eye Prep.)Absorption: Absorption after ophthalmic use is minimal.Onset of Action for Tobramycin (Eye Prep.)N/ADuration of Action for Tobramycin (Eye Prep.)N/AHalf Life of Tobramycin (Eye Prep.)N/ASide Effects of Tobramycin (Eye Prep.)1. Burning
2. Stinging
3. Swelling of the eyelids
4. Blurred vision
5. Rredness
6. Irritation
7. Itching
8. Sensitivity to light may occur
9. Conjunctival Erythema
Contra-indications of Tobramycin (Eye Prep.)1. Hypersensitivity to TobramycinSpecial Precautions while taking Tobramycin (Eye Prep.)1. Prolonged use
2. If irritation occurs then discontinue the use of medicaments
3. Avoid contact lenses
4. Wear sun glasses if sensitivity to sunlight occurs
5. Avoid driving vehicle, operating machine since it produces blurred vision
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicated
NEONATES : Contraindicated
Indications for Tobramycin (Eye Prep.)Treatment of external infections of the eye and its adnexa caused by susceptible bacteriaInteractions for Tobramycin (Eye Prep.)N/ATypical Dosage for Tobramycin (Eye Prep.)0.3% Tobramycin eye drops or ointment is used.
Eye Drops:
Mild to moderate disease: Instill 1 - 2 drops into the affected eye every 4 hours for 7 to 10 days.
In severe infections: Instill 2drops into the eye every 1 hour until improvement, and then reduce the dose.
Eye Ointment contains 3 mg/g Tobramycin
Mild to moderate disease: apply a 1 - 1.5 cm ribbon into the affected eye 2-3 times per day.
In severe infection, instill a 1 - 1.5 cm ribbon into the affected eye every 3 - 4 hours until improvement, and then reduce the dose.
Schedule of Tobramycin (Eye Prep.)N/AStorage Requirements for Tobramycin (Eye Prep.)Store at cool dry place. Protect from light. Do not freeze. Keep out of the reach of children. Avoid use of medicament 1 month after opening.Effects of Missed Dosage of Tobramycin (Eye Prep.)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Tobramycin (Eye Prep.)Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes. Home Delivery for Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.) in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including fluorometholone (eye.prep.) + tobramycin (eye prep.).
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for fluorometholone (eye.prep.) + tobramycin (eye prep.) and other medicines and health products. Home delivery services for fluorometholone (eye.prep.) + tobramycin (eye prep.) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take fluorometholone (eye.prep.) + tobramycin (eye prep.) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for fluorometholone (eye.prep.) + tobramycin (eye prep.) before they complete the sale. You can get this information while placing the order for fluorometholone (eye.prep.) + tobramycin (eye prep.) with the pharmacy.
Fluorometholone (Eye.Prep.) + Tobramycin (Eye Prep.) is a generic medicine name and there are several brands available for it. Some of the brands for fluorometholone (eye.prep.) + tobramycin (eye prep.) might be better known than fluorometholone (eye.prep.) + tobramycin (eye prep.) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fluorometholone (eye.prep.) + tobramycin (eye prep.) in stock, you can ask for one of the branded alternatives for fluorometholone (eye.prep.) + tobramycin (eye prep.).