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- Pharmacology For Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops)
Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops) Pharmacology
Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops)
About Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops)N/AMechanism of Action of Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops)N/APharmacokinets of Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops)N/AOnset of Action for Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops)N/ADuration of Action for Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops)N/AHalf Life of Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops)N/ASide Effects of Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops)N/AContra-indications of Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops)N/ASpecial Precautions while taking Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops)N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops)N/AInteractions for Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops)N/ATypical Dosage for Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops)N/ASchedule of Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops)N/AStorage Requirements for Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops)N/AEffects of Missed Dosage of Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops)N/AEffects of Overdose of Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops)N/ADexamethasone (Eye Pre.)
About Dexamethasone (Eye Pre.)N/AMechanism of Action of Dexamethasone (Eye Pre.)The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Dexamethasone drops are used to treat inflammatory conditions of the eye. It provides relief from inflammation, redness, irritation, allergies and other conditions.
Pharmacokinets of Dexamethasone (Eye Pre.)Absorption: Dexamethasone is minimally absorbed after instillation into the eyeOnset of Action for Dexamethasone (Eye Pre.)N/ADuration of Action for Dexamethasone (Eye Pre.)N/AHalf Life of Dexamethasone (Eye Pre.)N/ASide Effects of Dexamethasone (Eye Pre.)1.Burning
2.Redness
3.Stinging in the eye
4.Blurred vision
Contra-indications of Dexamethasone (Eye Pre.)1.Hypersensitivity to DexamethasoneSpecial Precautions while taking Dexamethasone (Eye Pre.)1.Cataracts
2.Contact lens wearer
3.Diabetes
4.Glaucoma
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Dexamethasone (Eye Pre.)1.Ophthalmic disorders
2.Eye inflammationInteractions for Dexamethasone (Eye Pre.)N/ATypical Dosage for Dexamethasone (Eye Pre.)Ophthalmic disorders:Apply 0.05-0.1% into the affected eye.
Eye inflammation: Instill 0.1% of the solution 4- 6 times daily.Dose can be reduced if symptoms are controlled.
Schedule of Dexamethasone (Eye Pre.)N/AStorage Requirements for Dexamethasone (Eye Pre.)Store at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of Dexamethasone (Eye Pre.)Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Dexamethasone (Eye Pre.)Give supportive measures and symptomatic treatment.Gentamicin (Eye/Ear Drops)
About Gentamicin (Eye/Ear Drops)It is an aminoglycoside antiinfective preparation.Mechanism of Action of Gentamicin (Eye/Ear Drops)Gentamicin exerts its bactericidal action against gram- negative organisms & some of gram positive organisms by inhibiting bacterial protein synthesis. The process involves 1.Penetration of bacterial cell membrane & binding directly to the bacterial ribosome, 2.Misleading of m-RNA codon by bacterial ribosome, 3.Formation of peptide chains with wrong amino acid sequence which gets incorporated into bacterial cell membrane and alters its permeability, 4.Bacterial cell lysis. Some bacterial strains resistant to other amino glycosides are sensitive to GentamicinPharmacokinets of Gentamicin (Eye/Ear Drops)Absorption: Only a very small amount of the drug enter in to the systemic circulationOnset of Action for Gentamicin (Eye/Ear Drops)N/ADuration of Action for Gentamicin (Eye/Ear Drops)N/AHalf Life of Gentamicin (Eye/Ear Drops)N/ASide Effects of Gentamicin (Eye/Ear Drops)1.Burning
2.Irritation
3.Itching
4.Swelling
5.Redness
6.Pain in or around the eyes or ears
7.Hearing loss
8.Ringing in the ear
9.Dizziness
10.Loss of coordination
11.Stinging
Contra-indications of Gentamicin (Eye/Ear Drops)1. Hypersensitivity to GentamicinSpecial Precautions while taking Gentamicin (Eye/Ear Drops)1. Prolonged use
2. If irritation occurs then discontinue the use of medicaments
3. Avoid contact lenses
Pregnancy Related InformationEYE DROPS: EAR DROPS:
Use with caution Contraindicated
Old Age Related InformationEYE DROPS: EAR DROPS:
Use with caution Use with cautionBreast Feeding Related InformationEYE DROPS: EAR DROPS:
Use with caution ContraindicatedChildren Related InformationEYE DROPS: EAR DROPS:
Use with caution Use with caution
NEONATES:
EYE DROPS: EAR DROPS:
Contraindicated ContraindicatedIndications for Gentamicin (Eye/Ear Drops)1.Bacterial Otitis externa
2.External ocular infections
Interactions for Gentamicin (Eye/Ear Drops)N/ATypical Dosage for Gentamicin (Eye/Ear Drops)Gentamicin 0.3% w/v solution is available.
Eyes: 1 or 2 drops should be instilled in the affected eye up to 3 - 4 times a day, or more times if required and then reduce the dose until the infection is controlled
Ears: The area should be cleaned and 2 - 3 drops instilled in the affected ear three to four times a day and at night, or more frequently if required.
Schedule of Gentamicin (Eye/Ear Drops)N/AStorage Requirements for Gentamicin (Eye/Ear Drops)Store at cool dry place. Do not freeze. Keep out of the reach of childrenEffects of Missed Dosage of Gentamicin (Eye/Ear Drops)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Gentamicin (Eye/Ear Drops)Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes. Home Delivery for Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops) in Your City
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Dexamethasone (Eye Pre.) + Gentamicin (Eye/Ear Drops) is a generic medicine name and there are several brands available for it. Some of the brands for dexamethasone (eye pre.) + gentamicin (eye/ear drops) might be better known than dexamethasone (eye pre.) + gentamicin (eye/ear drops) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dexamethasone (eye pre.) + gentamicin (eye/ear drops) in stock, you can ask for one of the branded alternatives for dexamethasone (eye pre.) + gentamicin (eye/ear drops).