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- Pharmacology For Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops)
Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops) Pharmacology
Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops)
About Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops)N/AMechanism of Action of Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops)N/APharmacokinets of Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops)N/AOnset of Action for Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops)N/ADuration of Action for Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops)N/AHalf Life of Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops)N/ASide Effects of Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops)N/AContra-indications of Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops)N/ASpecial Precautions while taking Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops)N/APregnancy Related InformationEar drops: Contraindicated; since Gentamicin ear drop is contraindicated in pregnancy.
Eye drops:Use with caution; Since Gentamicin eye drop is used with caution in breast feeding mother.
Old Age Related InformationN/ABreast Feeding Related InformationEar drops: Contraindicated; Gentamicin ear drop is contraindicated in breast feeding mother.
Eye drops:Use with caution; Since Gentamicin eye drop is used with caution in breast feeding mother.
Children Related InformationN/AIndications for Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops)It is the combination of corticosteroid Betamethasone and antibiotic Gentamicin.
1. Otitis media
2. Inflammatory and allergic condition of the ear
Interactions for Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops)N/ATypical Dosage for Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops)1 -2 drops to be applied to the ear 3 - 4 times dailySchedule of Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops)N/AStorage Requirements for Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops)N/AEffects of Missed Dosage of Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops)N/AEffects of Overdose of Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops)N/ABetamethasone (Eye/Ear)
About Betamethasone (Eye/Ear)Potent glucocorticoid, Anti-inflammatory.Mechanism of Action of Betamethasone (Eye/Ear)
The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Betamethasone (Eye/Ear)Absorption:It is administered as eye dropOnset of Action for Betamethasone (Eye/Ear)N/ADuration of Action for Betamethasone (Eye/Ear)N/AHalf Life of Betamethasone (Eye/Ear)N/ASide Effects of Betamethasone (Eye/Ear)1.Itching
2.Blurred vision
3.Burning sensation
4.Eye irritation
5.Allergic dermatitis
6.Increased pressure within the eye
7.Stinging
Contra-indications of Betamethasone (Eye/Ear)1.Eye conditions producing pus
2.Fungal infections of the eye
3.Glaucoma
4.Herpetic keratitis
5.Tuberculosis infection affecting the eye
6.Viral infections of the eye
Special Precautions while taking Betamethasone (Eye/Ear)Prolonged usePregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationUse with cautionIndications for Betamethasone (Eye/Ear)1.Inflammation of the eyeInteractions for Betamethasone (Eye/Ear)N/ATypical Dosage for Betamethasone (Eye/Ear)Adult:Apply the eye drop every 1-2 hours until controlled and then reduce the frequency 2 - 4 times daily. Schedule of Betamethasone (Eye/Ear)N/AStorage Requirements for Betamethasone (Eye/Ear)Store in a cool, dry place. Protect from direct light and heat. Discard this preparation one month after opening. Keep out of reach of childrenEffects of Missed Dosage of Betamethasone (Eye/Ear)Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Betamethasone (Eye/Ear)Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutesGentamicin (Eye/Ear Drops)
About Gentamicin (Eye/Ear Drops)It is an aminoglycoside antiinfective preparation.Mechanism of Action of Gentamicin (Eye/Ear Drops)Gentamicin exerts its bactericidal action against gram- negative organisms & some of gram positive organisms by inhibiting bacterial protein synthesis. The process involves 1.Penetration of bacterial cell membrane & binding directly to the bacterial ribosome, 2.Misleading of m-RNA codon by bacterial ribosome, 3.Formation of peptide chains with wrong amino acid sequence which gets incorporated into bacterial cell membrane and alters its permeability, 4.Bacterial cell lysis. Some bacterial strains resistant to other amino glycosides are sensitive to GentamicinPharmacokinets of Gentamicin (Eye/Ear Drops)Absorption: Only a very small amount of the drug enter in to the systemic circulationOnset of Action for Gentamicin (Eye/Ear Drops)N/ADuration of Action for Gentamicin (Eye/Ear Drops)N/AHalf Life of Gentamicin (Eye/Ear Drops)N/ASide Effects of Gentamicin (Eye/Ear Drops)1.Burning
2.Irritation
3.Itching
4.Swelling
5.Redness
6.Pain in or around the eyes or ears
7.Hearing loss
8.Ringing in the ear
9.Dizziness
10.Loss of coordination
11.Stinging
Contra-indications of Gentamicin (Eye/Ear Drops)1. Hypersensitivity to GentamicinSpecial Precautions while taking Gentamicin (Eye/Ear Drops)1. Prolonged use
2. If irritation occurs then discontinue the use of medicaments
3. Avoid contact lenses
Pregnancy Related InformationEYE DROPS: EAR DROPS:
Use with caution Contraindicated
Old Age Related InformationEYE DROPS: EAR DROPS:
Use with caution Use with cautionBreast Feeding Related InformationEYE DROPS: EAR DROPS:
Use with caution ContraindicatedChildren Related InformationEYE DROPS: EAR DROPS:
Use with caution Use with caution
NEONATES:
EYE DROPS: EAR DROPS:
Contraindicated ContraindicatedIndications for Gentamicin (Eye/Ear Drops)1.Bacterial Otitis externa
2.External ocular infections
Interactions for Gentamicin (Eye/Ear Drops)N/ATypical Dosage for Gentamicin (Eye/Ear Drops)Gentamicin 0.3% w/v solution is available.
Eyes: 1 or 2 drops should be instilled in the affected eye up to 3 - 4 times a day, or more times if required and then reduce the dose until the infection is controlled
Ears: The area should be cleaned and 2 - 3 drops instilled in the affected ear three to four times a day and at night, or more frequently if required.
Schedule of Gentamicin (Eye/Ear Drops)N/AStorage Requirements for Gentamicin (Eye/Ear Drops)Store at cool dry place. Do not freeze. Keep out of the reach of childrenEffects of Missed Dosage of Gentamicin (Eye/Ear Drops)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Gentamicin (Eye/Ear Drops)Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes. Home Delivery for Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops) in Your City
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Betamethasone (Eye/Ear) + Gentamicin (Eye/Ear Drops) is a generic medicine name and there are several brands available for it. Some of the brands for betamethasone (eye/ear) + gentamicin (eye/ear drops) might be better known than betamethasone (eye/ear) + gentamicin (eye/ear drops) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have betamethasone (eye/ear) + gentamicin (eye/ear drops) in stock, you can ask for one of the branded alternatives for betamethasone (eye/ear) + gentamicin (eye/ear drops).