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- Pharmacology For Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.)
Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.) Pharmacology
Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.)
About Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.)N/AMechanism of Action of Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.)N/APharmacokinets of Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.)N/AOnset of Action for Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.)N/ADuration of Action for Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.)N/AHalf Life of Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.)N/ASide Effects of Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.)N/AContra-indications of Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.)N/ASpecial Precautions while taking Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.)N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.)N/AInteractions for Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.)N/ATypical Dosage for Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.)N/ASchedule of Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.)N/AStorage Requirements for Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.)N/AEffects of Missed Dosage of Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.)N/AEffects of Overdose of Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.)N/ADexamethasone (Eye Pre.)
About Dexamethasone (Eye Pre.)N/AMechanism of Action of Dexamethasone (Eye Pre.)The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Dexamethasone drops are used to treat inflammatory conditions of the eye. It provides relief from inflammation, redness, irritation, allergies and other conditions.
Pharmacokinets of Dexamethasone (Eye Pre.)Absorption: Dexamethasone is minimally absorbed after instillation into the eyeOnset of Action for Dexamethasone (Eye Pre.)N/ADuration of Action for Dexamethasone (Eye Pre.)N/AHalf Life of Dexamethasone (Eye Pre.)N/ASide Effects of Dexamethasone (Eye Pre.)1.Burning
2.Redness
3.Stinging in the eye
4.Blurred vision
Contra-indications of Dexamethasone (Eye Pre.)1.Hypersensitivity to DexamethasoneSpecial Precautions while taking Dexamethasone (Eye Pre.)1.Cataracts
2.Contact lens wearer
3.Diabetes
4.Glaucoma
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Dexamethasone (Eye Pre.)1.Ophthalmic disorders
2.Eye inflammationInteractions for Dexamethasone (Eye Pre.)N/ATypical Dosage for Dexamethasone (Eye Pre.)Ophthalmic disorders:Apply 0.05-0.1% into the affected eye.
Eye inflammation: Instill 0.1% of the solution 4- 6 times daily.Dose can be reduced if symptoms are controlled.
Schedule of Dexamethasone (Eye Pre.)N/AStorage Requirements for Dexamethasone (Eye Pre.)Store at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of Dexamethasone (Eye Pre.)Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Dexamethasone (Eye Pre.)Give supportive measures and symptomatic treatment.Gatifloxacin (Eye Prep.)
About Gatifloxacin (Eye Prep.)Fourth-generation fluoroquinolone, DNA Gyrase Inhibitor,Topoisomerase I Inhibitor, Ophthalmic Antibiotic.Mechanism of Action of Gatifloxacin (Eye Prep.)Gatifloxacin acts by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Gatifloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis in microorganism.Pharmacokinets of Gatifloxacin (Eye Prep.)Absorption: Absorption after ophthalmic application is minimal.Onset of Action for Gatifloxacin (Eye Prep.)N/ADuration of Action for Gatifloxacin (Eye Prep.)N/AHalf Life of Gatifloxacin (Eye Prep.)N/ASide Effects of Gatifloxacin (Eye Prep.)1.Burning
2.Irritation
3.Itching
4.Bitter taste
5.Blurred vision
6.Increased sensitivity of the eyes to light
7.Redness
8.Swelling
9.Pain
10.Anaphylactic reactions
Contra-indications of Gatifloxacin (Eye Prep.)1.Hypersensitivity to Gatifloxacin and other Fluoroquinolones
2.Not use injection or subconjunctivally in to the eye
Special Precautions while taking Gatifloxacin (Eye Prep.)1.Prolonged use
2.If irritation occurs then discontinue the use of medicaments
3.Avoid contact lenses
4.Wear sun glasses if sensitivity to sunlight occurs
5.Avoid driving vehicle since it causes blurred vision
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Gatifloxacin (Eye Prep.)1.Conjunctivitis
2.Corneal ulcers
3.Keratitis
4.Blepharitis
5.Dacrocystitis
6.Trachoma
7.Keratoconjunctivitis
8.Acute meibomianitis
9.Prophylaxis of ocular infections
Interactions for Gatifloxacin (Eye Prep.)N/ATypical Dosage for Gatifloxacin (Eye Prep.)Gatifloxacin 0.3 %w/v drops is available.
Initial dose: Instill one drop every two hours in the affected eye while awake, up to 8 times daily for 2 days then instill one drop up to 4 times daily for next 5 days.
Eye ointment: Apply ? inch ribbon 3 times daily for 2 days and then reduce the dose to 2 times daily for next 5 days.
Schedule of Gatifloxacin (Eye Prep.)N/AStorage Requirements for Gatifloxacin (Eye Prep.)Store at cool dry place. Protect from light. Do not freeze. Keep out of the reach of children. Avoid use of medicament 1 month after opening.Effects of Missed Dosage of Gatifloxacin (Eye Prep.)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Gatifloxacin (Eye Prep.)Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes. Home Delivery for Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.) in Your City
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Dexamethasone (Eye Pre.) + Gatifloxacin (Eye Prep.) is a generic medicine name and there are several brands available for it. Some of the brands for dexamethasone (eye pre.) + gatifloxacin (eye prep.) might be better known than dexamethasone (eye pre.) + gatifloxacin (eye prep.) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dexamethasone (eye pre.) + gatifloxacin (eye prep.) in stock, you can ask for one of the branded alternatives for dexamethasone (eye pre.) + gatifloxacin (eye prep.).