- Medicine India
- Generic Medicines
- F
- Pharmacology For Fluorometholone (Eye.Prep.) + Neomycin
Fluorometholone (Eye.Prep.) + Neomycin Pharmacology
Fluorometholone (Eye.Prep.) + Neomycin
About Fluorometholone (Eye.Prep.) + NeomycinN/AMechanism of Action of Fluorometholone (Eye.Prep.) + NeomycinN/APharmacokinets of Fluorometholone (Eye.Prep.) + NeomycinN/AOnset of Action for Fluorometholone (Eye.Prep.) + NeomycinN/ADuration of Action for Fluorometholone (Eye.Prep.) + NeomycinN/AHalf Life of Fluorometholone (Eye.Prep.) + NeomycinN/ASide Effects of Fluorometholone (Eye.Prep.) + NeomycinN/AContra-indications of Fluorometholone (Eye.Prep.) + NeomycinN/ASpecial Precautions while taking Fluorometholone (Eye.Prep.) + NeomycinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Fluorometholone (Eye.Prep.) + NeomycinN/AInteractions for Fluorometholone (Eye.Prep.) + NeomycinN/ATypical Dosage for Fluorometholone (Eye.Prep.) + NeomycinN/ASchedule of Fluorometholone (Eye.Prep.) + NeomycinN/AStorage Requirements for Fluorometholone (Eye.Prep.) + NeomycinN/AEffects of Missed Dosage of Fluorometholone (Eye.Prep.) + NeomycinN/AEffects of Overdose of Fluorometholone (Eye.Prep.) + NeomycinN/AFluorometholone (Eye.Prep.)
About Fluorometholone (Eye.Prep.)A Synthetic Glucocorticoid, In steroid responsive inflammations of Eye( topical anti-inflammatory).Mechanism of Action of Fluorometholone (Eye.Prep.)The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Fluorometholone (Eye.Prep.)N/AOnset of Action for Fluorometholone (Eye.Prep.)N/ADuration of Action for Fluorometholone (Eye.Prep.)N/AHalf Life of Fluorometholone (Eye.Prep.)N/ASide Effects of Fluorometholone (Eye.Prep.)1.Elevation of intraocular pressure
2.Optic nerve damage
3.Posterior subcapsular cataract formation
4.Delayed wound healing
5.Acute anterior uveitis
6.Keratitis
7.Conjunctivitis
8.Corneal ulcers
9.Mydriasis
10.Conjunctival hyperemia
11.Loss of accommodation
12.Ptosis
13.Transient burning
14.Stinging
15.Ocular irritation
16.Taste perversion
17.Blurred visionContra-indications of Fluorometholone (Eye.Prep.)1.Hypersensitivity to Fluorometholone
2.Viral and fungal disease of the eye
Special Precautions while taking Fluorometholone (Eye.Prep.)1.Glaucoma
2.Regular monitoring of intraocular pressure should be required
3.Cataract surgery may delay healing
4.Patient wearing contact lenses
Pregnancy Related InformationContraindicatedOld Age Related InformationContraindicatedBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below 2 years: Contraindicated
Indications for Fluorometholone (Eye.Prep.)Corticosteroid responsive inflammation of eyeInteractions for Fluorometholone (Eye.Prep.)N/ATypical Dosage for Fluorometholone (Eye.Prep.)Instill one drop 2 - 4 times daily. If signs and symptoms fail to improve after two days, the patient should be re-evaluated. The drug should be withdraw gradually.Schedule of Fluorometholone (Eye.Prep.)N/AStorage Requirements for Fluorometholone (Eye.Prep.)Store at room temperature at 15 - 30 degree Celsius. Avoid freezing. Shake well before use. Keep out of the reach of children.Effects of Missed Dosage of Fluorometholone (Eye.Prep.)Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule.Effects of Overdose of Fluorometholone (Eye.Prep.)Give supportive measures and symptomatic treatment.Neomycin
About NeomycinAn aminoglycoside, Antibiotic, Ammonium Detoxicant.Mechanism of Action of NeomycinThis aminoglycoside cause protein synthesis inhibition by "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Neomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.Pharmacokinets of NeomycinAbsorption- Poorly absorbed after oral administration
Distribution- Rapidly distributed in the body after oral administration. 30% bound to the plasma proteins. It crosses the placenta
Metabolism- Not metabolized
Excretion- Excreted through urine and feces (primarily as unchanged form). It also excreted through breast milk
Onset of Action for Neomycin1 to 4 hr after oral administrationDuration of Action for Neomycin8hrs after oral administrationHalf Life of NeomycinIts plasma half life is 2 to 3 hrsSide Effects of Neomycin1. Rash
2. Diarrhoea
3. Inflammation of the large intestine (colitis)
4. Nausea
5. Vomiting
6. Ototoxicity
7. Damage to the kidneys
8. Damage to vestibular function within the ear
Contra-indications of Neomycin1. Hypersensitivity to the drug or any ingredients of it
2. Hypersensitivity to other amino glycosides
3. Intestinal obstruction
Special Precautions while taking Neomycin1. Impaired renal function
2. Neuromuscular disorder
3. Ulcerative bowel lesions
4. Extensive dermatologic conditions
5. Any other eye infection or condition
6. Glaucoma
7. Cataract surgery
8. Blockage of the bowel
9. Eighth-cranial-nerve disease (loss of hearing and/or balance)
10. Kidney disease
11. Myasthenia gravis
12. Parkinson`s disease
13. Ulcers of the bowel
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Neomycin1. Coma due to liver disease
2. Preventing infection following surgery
3. Topical infections
4. Systemic infections
Interactions for NeomycinN/ATypical Dosage for NeomycinOphthalmic suspension:
Adults-
1 or 2 drops every three or four hours- For eye infection
Oral (solution, tablets):
Adults and teenagers-
1 to 3 grams every six hours for five or six days- coma from liver disease
Adults and teenagers-
1 gram every hour for four hours, then 1 gram every four hours for the rest of a twenty-four hour period; or 1 gram nineteen hours before surgery, 1 gram eighteen hours before surgery, and 1 gram nine hours before surgery- cleaning the bowel before surgery.
Children-
14.7 milligrams mg/kg or 6.7 mg/ pound every four hours for three days
Ear preparation:
Adults and children-
2 to 5 drops into ear canal 3 to 4 times daily for 7 to 10 days- External ear canal infection
Schedule of NeomycinCStorage Requirements for NeomycinEye preparations store in the refrigerator protected from strong light. Do not freeze. Others are stored at <250C. Keep out of reach of children.Effects of Missed Dosage of NeomycinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of NeomycinGive symptomatic and supportive treatment. Provide haemodialysis or peritoneal dialysis to remove the drug. Treated with calcium salts or anticholinesterase to reverses neuromuscular blockade. Administer activated charcoal to prevent the further absorption of drugHome Delivery for Fluorometholone (Eye.Prep.) + Neomycin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including fluorometholone (eye.prep.) + neomycin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for fluorometholone (eye.prep.) + neomycin and other medicines and health products. Home delivery services for fluorometholone (eye.prep.) + neomycin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take fluorometholone (eye.prep.) + neomycin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for fluorometholone (eye.prep.) + neomycin before they complete the sale. You can get this information while placing the order for fluorometholone (eye.prep.) + neomycin with the pharmacy.
Fluorometholone (Eye.Prep.) + Neomycin is a generic medicine name and there are several brands available for it. Some of the brands for fluorometholone (eye.prep.) + neomycin might be better known than fluorometholone (eye.prep.) + neomycin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fluorometholone (eye.prep.) + neomycin in stock, you can ask for one of the branded alternatives for fluorometholone (eye.prep.) + neomycin.