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- Pharmacology For Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)
Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.) Pharmacology
Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)
About Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)N/AMechanism of Action of Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)N/APharmacokinets of Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)N/AOnset of Action for Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)N/ADuration of Action for Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)N/AHalf Life of Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)N/ASide Effects of Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)N/AContra-indications of Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)N/ASpecial Precautions while taking Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)N/APregnancy Related InformationContraindicated; since Chloramphenicol is contraindicated in pregnancy; the combination generic is contraindicated in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Chloramphenicol is contraindicated in breast feeding; the combination generic is contraindicated in breast feeding mother.Children Related InformationN/AIndications for Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)1.Ocular infectionsInteractions for Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)N/ATypical Dosage for Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)1 - 2 drop should be instilled in the eye 2 - 4 times dailySchedule of Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)N/AStorage Requirements for Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)N/AEffects of Missed Dosage of Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)N/AEffects of Overdose of Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)N/AChloramphenicol (Eye/Ear Drops)
About Chloramphenicol (Eye/Ear Drops)Bacteriostatic broad-spectrum antibiotic, ophthalmic antibacterial agent for ocular infections.Mechanism of Action of Chloramphenicol (Eye/Ear Drops)Chloramphenicol is a broad spectrum antibiotic which is primarily bacteriostatic at low concentration and exerts bactericidal action at higher concentration. It acts by inhibiting bacterial protein synthesis. Chloramphenicol attaches to 50S subunit of ribosome and interfering with transfer of elongating peptide chain to the newly attached aminoacyl-tRNA at the ribosome-m RNA complex. It prevents the access of aminoacyl-tRNA to the acceptor site for amino acid incorporation. By acting as a peptide analogue it inhibits peptide bond formation.
Chloramphenicol eye/ear drops or eye ointment which are applied to the eye/ear directly act on the bacteria which produces infection.
Pharmacokinets of Chloramphenicol (Eye/Ear Drops)Absorption: Only a very small amount of the drug enters in to the systemic circulation:Onset of Action for Chloramphenicol (Eye/Ear Drops)N/ADuration of Action for Chloramphenicol (Eye/Ear Drops)N/AHalf Life of Chloramphenicol (Eye/Ear Drops)N/ASide Effects of Chloramphenicol (Eye/Ear Drops)1.Burning
2.Stinging
3.Hypersensitivity reactions( Anaphylaxis, Angioneurotic edema, Urticaria, Fever, Vesicular and maculopapular dermatitis)Contra-indications of Chloramphenicol (Eye/Ear Drops)1.Hypersensitivity to Chloramphenicol
2.Myelosuppression during previous exposure to Chloramphenicol
3.Blood dyscrasias
4.Perforated ear drum (ear drops)Special Precautions while taking Chloramphenicol (Eye/Ear Drops)1.Prolonged use
2.If irritation occurs then discontinue the use of medicaments
3.Avoid contact lenses
4.Avoid driving vehicle or operating machine since Chloramphenicol eye drops produces blurred vision
5.If you are using more than one type of eye drop you should administer them at least five minutes apart, to prevent the second drop washing away the first. Use eye gels or ointments lastPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
CHILDREN below 2 years: contraindicatedIndications for Chloramphenicol (Eye/Ear Drops)EYE DROPS:
1.Bacterial conjunctivitis
2.Corneal ulcers
3.Trachoma
4.Ocular infections
EAR DROPS:
1.Bacterial Otitis externa
2.Chronic Otitis media
3.Pre and post aural or mastoid surgery
Interactions for Chloramphenicol (Eye/Ear Drops)N/ATypical Dosage for Chloramphenicol (Eye/Ear Drops)Chloramphenicol eye drops 0.4%, 0.5% and 1% and eye ointments 1% w/v is available.
Eyes: 1 drop should be instilled in the infected eye every 2 hours for 2 days and thereafter every 4 hours for up to 5 days. Do not use during sleep.
Chloramphenicol 5% w/v drop is used
Ears: The area should be cleaned and 2 - 3 drops instilled in the infected ear 3 - 4 times a day for up to 1 week
Children: 1 - 2 drops 3 times daily.
Schedule of Chloramphenicol (Eye/Ear Drops)N/AStorage Requirements for Chloramphenicol (Eye/Ear Drops)Stored in a refrigerator at 2? to 8?C.Protect from heat and light. Opened eye drops should be discarded after 5 days. Keep out of the reach of childrenEffects of Missed Dosage of Chloramphenicol (Eye/Ear Drops)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Chloramphenicol (Eye/Ear Drops)Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes. Prednisolone (Eye Pre.)
About Prednisolone (Eye Pre.)Ophthalmic synthetic Glucocorticoid, Ophthalmic anti-inflammatory.Mechanism of Action of Prednisolone (Eye Pre.)The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts more selective glucocorticoid action with little mineralocorticoid actions.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction. Prednisolone acetate 1% ophthalmic solution is used for inflammation of eye. Prednisolone acetate is 3 to 5 times more active than Hydrocortisone.
Pharmacokinets of Prednisolone (Eye Pre.)Absorption: It is absorbed after instilled into the eye.Onset of Action for Prednisolone (Eye Pre.)N/ADuration of Action for Prednisolone (Eye Pre.)N/AHalf Life of Prednisolone (Eye Pre.)N/ASide Effects of Prednisolone (Eye Pre.)1.Transient burning
2.Stinging
3.Ocular irritation
4.Blurred vision
5.Allergic reactions
Contra-indications of Prednisolone (Eye Pre.)1.Hypersensitivity to Prednisolone eye preparations
2.Epithelial herpes simplex keratitis
3.Bacterial and fungal infection of the eye
Special Precautions while taking Prednisolone (Eye Pre.)1.Prolonged use
2.Cataract
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicatedIndications for Prednisolone (Eye Pre.)Inflammation of eyeInteractions for Prednisolone (Eye Pre.)N/ATypical Dosage for Prednisolone (Eye Pre.)Instil 1-2 drops into the affected eye 2-4 times daily. Schedule of Prednisolone (Eye Pre.)N/AStorage Requirements for Prednisolone (Eye Pre.)Store in a cool place. Protect from light. Keep out of the reach of children.Effects of Missed Dosage of Prednisolone (Eye Pre.)Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Prednisolone (Eye Pre.)Give supportive measures and symptomatic treatment.Home Delivery for Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.) in Your City
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Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.) is a generic medicine name and there are several brands available for it. Some of the brands for chloramphenicol (eye/ear drops) + prednisolone (eye pre.) might be better known than chloramphenicol (eye/ear drops) + prednisolone (eye pre.) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have chloramphenicol (eye/ear drops) + prednisolone (eye pre.) in stock, you can ask for one of the branded alternatives for chloramphenicol (eye/ear drops) + prednisolone (eye pre.).