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- Pharmacology For Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops)
Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops) Pharmacology
Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops)
About Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops)N/AMechanism of Action of Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops)N/APharmacokinets of Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops)N/AOnset of Action for Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops)N/ADuration of Action for Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops)N/AHalf Life of Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops)N/ASide Effects of Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops)N/AContra-indications of Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops)N/ASpecial Precautions while taking Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops)N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops)N/AInteractions for Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops)N/ATypical Dosage for Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops)N/ASchedule of Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops)N/AStorage Requirements for Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops)N/AEffects of Missed Dosage of Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops)N/AEffects of Overdose of Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops)N/ADexamethasone (Eye Pre.)
About Dexamethasone (Eye Pre.)N/AMechanism of Action of Dexamethasone (Eye Pre.)The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Dexamethasone drops are used to treat inflammatory conditions of the eye. It provides relief from inflammation, redness, irritation, allergies and other conditions.
Pharmacokinets of Dexamethasone (Eye Pre.)Absorption: Dexamethasone is minimally absorbed after instillation into the eyeOnset of Action for Dexamethasone (Eye Pre.)N/ADuration of Action for Dexamethasone (Eye Pre.)N/AHalf Life of Dexamethasone (Eye Pre.)N/ASide Effects of Dexamethasone (Eye Pre.)1.Burning
2.Redness
3.Stinging in the eye
4.Blurred vision
Contra-indications of Dexamethasone (Eye Pre.)1.Hypersensitivity to DexamethasoneSpecial Precautions while taking Dexamethasone (Eye Pre.)1.Cataracts
2.Contact lens wearer
3.Diabetes
4.Glaucoma
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Dexamethasone (Eye Pre.)1.Ophthalmic disorders
2.Eye inflammationInteractions for Dexamethasone (Eye Pre.)N/ATypical Dosage for Dexamethasone (Eye Pre.)Ophthalmic disorders:Apply 0.05-0.1% into the affected eye.
Eye inflammation: Instill 0.1% of the solution 4- 6 times daily.Dose can be reduced if symptoms are controlled.
Schedule of Dexamethasone (Eye Pre.)N/AStorage Requirements for Dexamethasone (Eye Pre.)Store at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of Dexamethasone (Eye Pre.)Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Dexamethasone (Eye Pre.)Give supportive measures and symptomatic treatment.Ciprofloxacin (Eye/Ear Drops)
About Ciprofloxacin (Eye/Ear Drops)Second generation fluoroquinolone antibiotic, Ophthalmic Antibiotic.Mechanism of Action of Ciprofloxacin (Eye/Ear Drops)Ciprofloxacin is a bacteriostatic at low concentration and bactericidal at high concentration. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Ciprofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.Pharmacokinets of Ciprofloxacin (Eye/Ear Drops)Absorption: Absorption after topical application is minimal:Onset of Action for Ciprofloxacin (Eye/Ear Drops)N/ADuration of Action for Ciprofloxacin (Eye/Ear Drops)N/AHalf Life of Ciprofloxacin (Eye/Ear Drops)N/ASide Effects of Ciprofloxacin (Eye/Ear Drops)Eye drops:
1.Burning
2.Irritation
3.Itching
4.Swelling
5.Redness
6.Pain in or around the eyes
Ear drops:
1.Hearing loss
2.Ringing in the ear
3.Dizziness
4.Loss of coordination
5.Stinging
6.Headache
7.Unpleasant sensation
8.Tingling
9.Rashes
10.Worsening ear pain
Contra-indications of Ciprofloxacin (Eye/Ear Drops)1.Hypersensitivity to Ciprofloxacin
2.Perforations on the tympanic membrane (ear drops)Special Precautions while taking Ciprofloxacin (Eye/Ear Drops)1.Prolonged use
2.If irritation occurs then discontinue the use of medicaments
3.Avoid contact lenses
4.Wear sun glasses if sensitivity to sunlight occursPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Ciprofloxacin (Eye/Ear Drops)1.Bacterial infections of the ears (external Otitis)
2.External ocular infections-conjunctivitis, corneal ulcersInteractions for Ciprofloxacin (Eye/Ear Drops)N/ATypical Dosage for Ciprofloxacin (Eye/Ear Drops)Ciprofloxacin 0.3 %w/v solution is available.
Eye drops: 2 or 3 drops should be instilled in the affected eye for 2-3times daily,
Eye ointment: Apply ? inch ribbon 6 - 8 times daily and then reduce the dose depending on infection, for trachoma: Apply 6 - 12 hourly for 1 - 2 months
Ears: The area should be cleaned and 3 drops instilled in the affected ear 2 times daily for 1 week.
Schedule of Ciprofloxacin (Eye/Ear Drops)N/AStorage Requirements for Ciprofloxacin (Eye/Ear Drops)Store at cool dry place. Do not freeze. Keep out of the reach of childrenEffects of Missed Dosage of Ciprofloxacin (Eye/Ear Drops)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Ciprofloxacin (Eye/Ear Drops)Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes. Home Delivery for Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops) in Your City
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Please be aware that you should take dexamethasone (eye pre.) + ciprofloxacin (eye/ear drops) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dexamethasone (eye pre.) + ciprofloxacin (eye/ear drops) before they complete the sale. You can get this information while placing the order for dexamethasone (eye pre.) + ciprofloxacin (eye/ear drops) with the pharmacy.
Dexamethasone (Eye Pre.) + Ciprofloxacin (Eye/Ear Drops) is a generic medicine name and there are several brands available for it. Some of the brands for dexamethasone (eye pre.) + ciprofloxacin (eye/ear drops) might be better known than dexamethasone (eye pre.) + ciprofloxacin (eye/ear drops) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dexamethasone (eye pre.) + ciprofloxacin (eye/ear drops) in stock, you can ask for one of the branded alternatives for dexamethasone (eye pre.) + ciprofloxacin (eye/ear drops).