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- Pharmacology For Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.)
Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.) Pharmacology
Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.)
About Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.)N/AMechanism of Action of Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.)N/APharmacokinets of Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.)N/AOnset of Action for Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.)N/ADuration of Action for Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.)N/AHalf Life of Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.)N/ASide Effects of Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.)N/AContra-indications of Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.)N/ASpecial Precautions while taking Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.)N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.)N/AInteractions for Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.)N/ATypical Dosage for Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.)N/ASchedule of Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.)N/AStorage Requirements for Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.)N/AEffects of Missed Dosage of Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.)N/AEffects of Overdose of Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.)N/ADexamethasone (Eye Pre.)
About Dexamethasone (Eye Pre.)N/AMechanism of Action of Dexamethasone (Eye Pre.)The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Dexamethasone drops are used to treat inflammatory conditions of the eye. It provides relief from inflammation, redness, irritation, allergies and other conditions.
Pharmacokinets of Dexamethasone (Eye Pre.)Absorption: Dexamethasone is minimally absorbed after instillation into the eyeOnset of Action for Dexamethasone (Eye Pre.)N/ADuration of Action for Dexamethasone (Eye Pre.)N/AHalf Life of Dexamethasone (Eye Pre.)N/ASide Effects of Dexamethasone (Eye Pre.)1.Burning
2.Redness
3.Stinging in the eye
4.Blurred vision
Contra-indications of Dexamethasone (Eye Pre.)1.Hypersensitivity to DexamethasoneSpecial Precautions while taking Dexamethasone (Eye Pre.)1.Cataracts
2.Contact lens wearer
3.Diabetes
4.Glaucoma
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Dexamethasone (Eye Pre.)1.Ophthalmic disorders
2.Eye inflammationInteractions for Dexamethasone (Eye Pre.)N/ATypical Dosage for Dexamethasone (Eye Pre.)Ophthalmic disorders:Apply 0.05-0.1% into the affected eye.
Eye inflammation: Instill 0.1% of the solution 4- 6 times daily.Dose can be reduced if symptoms are controlled.
Schedule of Dexamethasone (Eye Pre.)N/AStorage Requirements for Dexamethasone (Eye Pre.)Store at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of Dexamethasone (Eye Pre.)Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Dexamethasone (Eye Pre.)Give supportive measures and symptomatic treatment.Tobramycin (Eye Prep.)
About Tobramycin (Eye Prep.)Aminoglycoside derivative, Ophthalmic Antibiotic.Mechanism of Action of Tobramycin (Eye Prep.)Tobramycin is a water soluble amino glycoside antibiotic active against a variety of ophthalmic bacterial pathogens.Tobramycin exerts its bactericidal action against gram- negative organisms & some of gram positive organisms by inhibiting bacterial protein synthesis. The process involves 1.Penetration of bacterial cell membrane & binding directly to the bacterial ribosome, 2.Misleading of m-RNA codon by bacterial ribosome, 3.Formation of peptide chains with wrong amino acid sequence which gets incorporated into bacterial cell membrane and alters its permeability, 4.Bacterial cell lysis. Some bacterial strains like pseudomonas are more sensitive to Tobramycin than GentamicinPharmacokinets of Tobramycin (Eye Prep.)Absorption: Absorption after ophthalmic use is minimal.Onset of Action for Tobramycin (Eye Prep.)N/ADuration of Action for Tobramycin (Eye Prep.)N/AHalf Life of Tobramycin (Eye Prep.)N/ASide Effects of Tobramycin (Eye Prep.)1. Burning
2. Stinging
3. Swelling of the eyelids
4. Blurred vision
5. Rredness
6. Irritation
7. Itching
8. Sensitivity to light may occur
9. Conjunctival Erythema
Contra-indications of Tobramycin (Eye Prep.)1. Hypersensitivity to TobramycinSpecial Precautions while taking Tobramycin (Eye Prep.)1. Prolonged use
2. If irritation occurs then discontinue the use of medicaments
3. Avoid contact lenses
4. Wear sun glasses if sensitivity to sunlight occurs
5. Avoid driving vehicle, operating machine since it produces blurred vision
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicated
NEONATES : Contraindicated
Indications for Tobramycin (Eye Prep.)Treatment of external infections of the eye and its adnexa caused by susceptible bacteriaInteractions for Tobramycin (Eye Prep.)N/ATypical Dosage for Tobramycin (Eye Prep.)0.3% Tobramycin eye drops or ointment is used.
Eye Drops:
Mild to moderate disease: Instill 1 - 2 drops into the affected eye every 4 hours for 7 to 10 days.
In severe infections: Instill 2drops into the eye every 1 hour until improvement, and then reduce the dose.
Eye Ointment contains 3 mg/g Tobramycin
Mild to moderate disease: apply a 1 - 1.5 cm ribbon into the affected eye 2-3 times per day.
In severe infection, instill a 1 - 1.5 cm ribbon into the affected eye every 3 - 4 hours until improvement, and then reduce the dose.
Schedule of Tobramycin (Eye Prep.)N/AStorage Requirements for Tobramycin (Eye Prep.)Store at cool dry place. Protect from light. Do not freeze. Keep out of the reach of children. Avoid use of medicament 1 month after opening.Effects of Missed Dosage of Tobramycin (Eye Prep.)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Tobramycin (Eye Prep.)Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes. Home Delivery for Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.) in Your City
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Dexamethasone (Eye Pre.) + Tobramycin (Eye Prep.) is a generic medicine name and there are several brands available for it. Some of the brands for dexamethasone (eye pre.) + tobramycin (eye prep.) might be better known than dexamethasone (eye pre.) + tobramycin (eye prep.) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dexamethasone (eye pre.) + tobramycin (eye prep.) in stock, you can ask for one of the branded alternatives for dexamethasone (eye pre.) + tobramycin (eye prep.).