Pefloxacin (Eye Prep.) Pharmacology

Pefloxacin (Eye Prep.)

About Pefloxacin (Eye Prep.)
A synthetic 2nd generation fluoroquinolone, Ophthalmic antibiotic.
Mechanism of Action of Pefloxacin (Eye Prep.)
Pefloxacin is a bacteriostatic at low concentration and bactericidal at high concentration. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Pefloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.

Pharmacokinets of Pefloxacin (Eye Prep.)
Absorption: Absorption after ophthalmic application is minimal
Onset of Action for Pefloxacin (Eye Prep.)
N/A
Duration of Action for Pefloxacin (Eye Prep.)
N/A
Half Life of Pefloxacin (Eye Prep.)
N/A
Side Effects of Pefloxacin (Eye Prep.)
1.Burning
2.Irritation
3.Itching
4.Bitter taste
5.Redness
6.Swelling
7.Blurred vision
Contra-indications of Pefloxacin (Eye Prep.)
1.Hypersensitivity to Pefloxacin and other Fluoroquinolones
Special Precautions while taking Pefloxacin (Eye Prep.)
1.Prolonged use
2.If irritation occurs then discontinue the use of medicaments
3.Avoid contact lenses
4.Wear sun glasses if sensitivity to sunlight occurs
5.Avoid driving vehicle, operating machine since it produces blurred vision
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
NEONATES: contraindicated
Indications for Pefloxacin (Eye Prep.)
1.Conjunctivitis
2.Corneal ulcers
3.Keratitis
4.Blepharitis
5.Dacrocystitis
6.Trachoma
7.Keratoconjunctivitis
8.Prophylaxis of ocular infections
9.Blepharo conjunctivitis
10.Acute meibomianitis
11.Pre and post ocular surgery
Interactions for Pefloxacin (Eye Prep.)
N/A
Typical Dosage for Pefloxacin (Eye Prep.)
Norfloxacin 0.3 %w/v drops and ointments are available.
Eye drops:
Acute infections: 1-2 drops every 15-30 minutes initially, further reduce to 2 - 6 times daily.
Moderately severe infections: 1-2 drops 2-6 times daily.
Severe infections: 2 drops should be instilled in to every hour
Acute and chronic trachoma: 2 drops in each eye, 2-4 times daily.
Eye ointment: Apply ? inch ribbon 6 - 8 times daily and then reduce the dose depending on infection
Schedule of Pefloxacin (Eye Prep.)
N/A
Storage Requirements for Pefloxacin (Eye Prep.)
Store at cool dry place. Protect from light. Do not freeze. Keep out of the reach of children. Avoid use of medicament 1 month after opening.

Effects of Missed Dosage of Pefloxacin (Eye Prep.)
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose
Effects of Overdose of Pefloxacin (Eye Prep.)
Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes.

Home Delivery for Pefloxacin (Eye Prep.) in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including pefloxacin (eye prep.).

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for pefloxacin (eye prep.) and other medicines and health products. Home delivery services for pefloxacin (eye prep.) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take pefloxacin (eye prep.) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for pefloxacin (eye prep.) before they complete the sale. You can get this information while placing the order for pefloxacin (eye prep.) with the pharmacy.

Pefloxacin (Eye Prep.) is a generic medicine name and there are several brands available for it. Some of the brands for pefloxacin (eye prep.) might be better known than pefloxacin (eye prep.) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have pefloxacin (eye prep.) in stock, you can ask for one of the branded alternatives for pefloxacin (eye prep.).