Ofloxacin (Eye Prep.) Pharmacology

Ofloxacin (Eye Prep.)

About Ofloxacin (Eye Prep.)
A second generation fluoroquinolone(quinolones), Ophthalmic Antibiotic.
Mechanism of Action of Ofloxacin (Eye Prep.)
Ofloxacin is a bactericidal drug. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Ofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.
Pharmacokinets of Ofloxacin (Eye Prep.)
Absorption: Absorption after ophthalmic application is minimal.
Onset of Action for Ofloxacin (Eye Prep.)
N/A
Duration of Action for Ofloxacin (Eye Prep.)
N/A
Half Life of Ofloxacin (Eye Prep.)
N/A
Side Effects of Ofloxacin (Eye Prep.)
1. Burning
2. Irritation
3. Itching
4. Bitter taste
5. Redness
6. Swelling
7. Blurred vision
8. Increased sensitivity of the eyes to light
9. Blistering
10. Swelling
11.Pain
Contra-indications of Ofloxacin (Eye Prep.)
1. Hypersensitivity to Ofloxacin and other Fluoroquinolones
Special Precautions while taking Ofloxacin (Eye Prep.)
1. Prolonged use
2. If irritation occurs then discontinue the use of medicaments
3. Avoid contact lenses
4. Wear sun glasses if sensitivity to sunlight occurs
5. Avoid driving vehicle, operating machine since it produces blurred vision
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
NEONATES : Contraindicated
Indications for Ofloxacin (Eye Prep.)
1. Conjunctivitis
2. Corneal ulcers
3. Keratitis
4. Blepharitis
5. Dacrocystitis
6. Trachoma
7. Keratoconjunctivitis
8. Prophylaxis of ocular infections
Interactions for Ofloxacin (Eye Prep.)
N/A
Typical Dosage for Ofloxacin (Eye Prep.)
Ofloxacin 0.3 %w/v drops and ointments are available.
Eye drops: 1-2 drops 6 times daily.
Severe infections: 2 drops should be applied to every hour.
Eye ointment: Apply ? inch ribbon 6 - 8 times daily and then reduce the dose depending on infection
Schedule of Ofloxacin (Eye Prep.)
N/A
Storage Requirements for Ofloxacin (Eye Prep.)
Store at cool dry place. Protect from light. Do not freeze. Keep out of the reach of children. Avoid use of medicament 1 month after opening.
Effects of Missed Dosage of Ofloxacin (Eye Prep.)
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ofloxacin (Eye Prep.)
Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes.

Home Delivery for Ofloxacin (Eye Prep.) in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ofloxacin (eye prep.).

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ofloxacin (eye prep.) and other medicines and health products. Home delivery services for ofloxacin (eye prep.) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ofloxacin (eye prep.) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ofloxacin (eye prep.) before they complete the sale. You can get this information while placing the order for ofloxacin (eye prep.) with the pharmacy.

Ofloxacin (Eye Prep.) is a generic medicine name and there are several brands available for it. Some of the brands for ofloxacin (eye prep.) might be better known than ofloxacin (eye prep.) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ofloxacin (eye prep.) in stock, you can ask for one of the branded alternatives for ofloxacin (eye prep.).