Hydroxyprogesterone Pharmacology

Hydroxyprogesterone

About Hydroxyprogesterone
A C-21 steroid hormone,Progestagen, Progestational agent, Diagnostic aid( estrogen production).
Mechanism of Action of Hydroxyprogesterone
It is a progestin derivative exerts it`s action through nuclear progesterone receptors situated in female genital tract, breast, CNS, and pituitary. When the drug binds to progesterone receptors it undergoes dimerization and attaches to progesterone response element of target genes and regulates transcription through coactivators; which ultimately leads to modification of protein synthesis. It contributes to proper development and maintenance of female sexual functions. It prepare uterus for nidation and maintenance of pregnancy. It prevents endometrial shedding, decreases uterine motility, and also inhibits immunological rejection of the foetus by decreasing T-cell function and cell mediated immunity.
Pharmacokinets of Hydroxyprogesterone
Absorption: Slowly absorbed after I.M. administration.
Metabolism: Metabolized in liver in to metabolites.
Excretion: Excreted mainly through urine.
Onset of Action for Hydroxyprogesterone
N/A
Duration of Action for Hydroxyprogesterone
14 days
Half Life of Hydroxyprogesterone
N/A
Side Effects of Hydroxyprogesterone
1. Pulmonary embolism
2. Thromboembolism
3. Cerebrovascular accident
4. Breakthrough bleeding
5. Dysmenorrhea
6. Amenorrhea
7. Cervical erosions and abnormal secretions
8. Tenderness and enlargement of breast
9. Cholestatic jaundice
10. Depression
11. Migraine
12. Rashes
13. Urticaria
14. Pruritus
Contra-indications of Hydroxyprogesterone
1. Hypersensitivity to the drug
2. Thromboembolic disorders
3. Cerebral apoplexy
4. Breast cancer
5. Hormone dependent carcinoma
6. Undiagnosed vaginal bleeding
7. Missed abortion
8. Liver tumors
9. Severe liver disease
10. Herpes of pregnancy
Special Precautions while taking Hydroxyprogesterone
1. Hepatic impairment
2. Renal impairment
3. Liver diseases
4. Cardiovascular disorders
5. Diabetes mellitus
6. Seizures
7. Mental depression
8. Migraine
9. Asthma
10. Monitor blood pressure, and for visual impairment
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Hydroxyprogesterone
1. Amenorrhea
2. Threatened abortion
3. Habitual abortion
4. Endometrial cancer
Interactions for Hydroxyprogesterone
N/A
Typical Dosage for Hydroxyprogesterone
I.M.:
Threatened abortion: 500mg twice weekly to thrice weekly.
Habitual abortion: 250mg to 500mg once weekly during first half of pregnancy.
Amenorrhea: 250 to 375mg Hydroxyprogesterone on 14th day of therapy; along with 10mg oestradiol valerate. Provide previous estrogen therapy with 20mg oestradiol valerate on first day of treatment. Repeat at intervals of four week if required.
Endometrial cancer: 1g up to seven times weekly for 12 weeks. Discontinue after 12 weeks if there is no objective response occur or if relapse occurs.
Schedule of Hydroxyprogesterone
N/A
Storage Requirements for Hydroxyprogesterone
Store at controlled room temperature at a range of 15 to 30 degree C in a light resistant well closed container. Keep out of reach of children.
Effects of Missed Dosage of Hydroxyprogesterone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Hydroxyprogesterone
N/A

Home Delivery for Hydroxyprogesterone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including hydroxyprogesterone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for hydroxyprogesterone and other medicines and health products. Home delivery services for hydroxyprogesterone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take hydroxyprogesterone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for hydroxyprogesterone before they complete the sale. You can get this information while placing the order for hydroxyprogesterone with the pharmacy.

Hydroxyprogesterone is a generic medicine name and there are several brands available for it. Some of the brands for hydroxyprogesterone might be better known than hydroxyprogesterone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have hydroxyprogesterone in stock, you can ask for one of the branded alternatives for hydroxyprogesterone.