Nafarelin Acetate Pharmacology

Nafarelin Acetate

About Nafarelin Acetate

A man-made hormone ,GnRH agonist, Antiendometriotic agent,in Central precocious puberty (CPP).

Mechanism of Action of Nafarelin Acetate

It is a long acting potent gonadotropin releasing hormone (GnRH) agonist. It stimulates the FSH and LH release from the pituitary which results in a temporary increase in the ovarian steroidogenesis. After 3 days of Nafarelin administration pituitary become refractory to further stimulation. Down regulation of pituitary GnRH receptors occurs in 10days which result in inhibition of FSH and LH release which leads to reduced secretion of gonadal steroids. Peak inhibition of gonadotropin release occurs in one month.

Pharmacokinets of Nafarelin Acetate

Absorption: Rapidly absorbed after intranasal administration. Distribution: Distributed in a protein bound form. Metabolism: It is broken down in the body to shorter peptide segments.

Onset of Action for Nafarelin Acetate

N/A

Duration of Action for Nafarelin Acetate

N/A

Half Life of Nafarelin Acetate

2.5 to 3 hours

Side Effects of Nafarelin Acetate

1.Hot flushes
2.Loss of libido
3.Osteoporosis
4.Vaginal dryness
5.Emotional lability
6.Headache
7.Depression
8.Irritation in nasal mucosa
9.Migraine

Contra-indications of Nafarelin Acetate

1.Hypersensitivity to the GnRH analogue, GnRH, or excipients in nasal spray
2.Undiagnosed vaginal bleeding

Special Precautions while taking Nafarelin Acetate

1.Should not administer nasal decongestants 30 to 120minutes before and after Nafarelin administration

Pregnancy Related Information

Contraindicated

Old Age Related Information

N/A

Breast Feeding Related Information

Contraindicated

Children Related Information

Use with caution

Indications for Nafarelin Acetate

1.Endometriosis
2.Central precocious puberty
3.Induces ovulation in invitro fertilization
4.For reducing lesion size in leiomyomas
5.Benign prostatic hypertrophy
6.Polycystic ovary
7.Hirsutism

Interactions for Nafarelin Acetate

Drug interactions are not expected to occur.

Typical Dosage for Nafarelin Acetate

Endometriosis: 200?g twice daily for 6 months taken as one spray to one nostril in the morning and one spray to the other nostril in the evening (400?g/day). Begin treatment between day 2-4 of the menstrual cycle.
Central precocious puberty: 1600?g/day as two sprays (400?g) into each nostril in the morning (4 sprays) and 2 sprays into each nostril in the evening (4 sprays), a total of 8 sprays/day.

Schedule of Nafarelin Acetate

N/A

Storage Requirements for Nafarelin Acetate

Store upright below 30 degree C. Protect from light and keep out of reach of children.

Effects of Missed Dosage of Nafarelin Acetate

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Nafarelin Acetate

Provide symptomatic treatment and supportive measures.

Home Delivery for Nafarelin Acetate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including nafarelin acetate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nafarelin acetate and other medicines and health products. Home delivery services for nafarelin acetate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take nafarelin acetate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nafarelin acetate before they complete the sale. You can get this information while placing the order for nafarelin acetate with the pharmacy.

Nafarelin Acetate is a generic medicine name and there are several brands available for it. Some of the brands for nafarelin acetate might be better known than nafarelin acetate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nafarelin acetate in stock, you can ask for one of the branded alternatives for nafarelin acetate.