- Medicine India
- Generic Medicines
- P
- Pharmacology For Pentazocine + Paracetamol
Pentazocine + Paracetamol Pharmacology
Pentazocine + Paracetamol
About Pentazocine + ParacetamolN/AMechanism of Action of Pentazocine + ParacetamolN/APharmacokinets of Pentazocine + ParacetamolN/AOnset of Action for Pentazocine + ParacetamolN/ADuration of Action for Pentazocine + ParacetamolN/AHalf Life of Pentazocine + ParacetamolN/ASide Effects of Pentazocine + ParacetamolN/AContra-indications of Pentazocine + ParacetamolN/ASpecial Precautions while taking Pentazocine + ParacetamolN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Pentazocine + ParacetamolN/AInteractions for Pentazocine + ParacetamolN/ATypical Dosage for Pentazocine + ParacetamolN/ASchedule of Pentazocine + ParacetamolN/AStorage Requirements for Pentazocine + ParacetamolN/AEffects of Missed Dosage of Pentazocine + ParacetamolN/AEffects of Overdose of Pentazocine + ParacetamolN/APentazocine
About PentazocineBenzomorphan derivative, Opioid Analgesic(centrally acting analgesic).Mechanism of Action of PentazocineIt is morphine like Opioid analgesic. Its analgesic action is due to the agonistic action at kappa Opioid receptors. At mu receptors it has weak agonistic and partial antagonistic action. It produces more dysphoria than euphoria because of the activation at supraspinal kappa receptors. Its psycho mimetic activity is due to the action at sigma Opioid receptors. On respiratory depression it has a ceiling effect i.e. by increasing the dose there is no increase of respiratory depression. Symptoms of withdrawal are less in this drug than morphine.Pharmacokinets of PentazocineAbsorption. Orally well absorbed but its bioavailability is low due to first pass metabolism. In patients with hepatic dysfunction can absorb 60-70% of the drug.It is rapidly absorbed after intra venous, intramuscular and subcutaneous administration.
Distribution:-Widely distributed in the body.
Metabolism -It undergoes metabolism by oxidation and glucoronidation in liver.
Excretion-It is excreted via urine and a small amount through faeces.
Onset of Action for PentazocineOral. 15-30min
Intravenous. 2 - 3min
Intramuscular and Subcutaneous. 10 - 20min
Duration of Action for Pentazocine2 - 3 hrsHalf Life of Pentazocine2 - 3 hrsSide Effects of Pentazocine1. Sedation
2. Light headedness
3. Euphoria
4. Psychomimetic effect
5. Shock
6. Hypertension
7. Hypotension
8. Constipation
9. Nausea
10. Vomiting
11. Urine retention
12. Respiratory depression
13. Dyspnea
14. Apnea
15. Sclerosis of injection site
16. Pruritis
17. Psychological dependence
Contra-indications of Pentazocine1. Hypersensitivity to the drug
2. Myocardial infarction
3. Hypertension
4. Pregnancy
6. Increased intracranial pressure
7. Respiratory failure
8. Narcotic dependence
Special Precautions while taking Pentazocine1. Labour
2. Elderly patients
3. Patients with head injury
4. Respiratory depression
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationN/AChildren Related InformationUse with cautionIndications for Pentazocine1. Pain in -Trauma, Surgery, Burns, Labour, Cancer
2. Pre- anaesthetic medication
Interactions for PentazocineAlcohol : Increased CNS depressant effects.
Barbiturate anaesthetics : May increase respiratory & CNS depression effects of pentazocine.Typical Dosage for PentazocineOral :
Adults -50 to 100 mg every 3-4 times.
Intravenous,Intramuscular and Subcutaneous - 30 to 60mg every 3-4 times.
Labour patient-30mg i.v or 20 mg i.m in 2 to 3 hour interval.
Rectal :50mg suppository 4 times daily.
Oral:
Children: 25mg every 3-4 times.
Schedule of PentazocineHStorage Requirements for PentazocineStore at room temperature.Effects of Missed Dosage of PentazocineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of PentazocineTake all supportive measures. Give mechanical ventilation. If respiratory depression occurs give an antagonistic parenterally e.g.Naloxone.Paracetamol
About ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Home Delivery for Pentazocine + Paracetamol in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including pentazocine + paracetamol.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for pentazocine + paracetamol and other medicines and health products. Home delivery services for pentazocine + paracetamol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take pentazocine + paracetamol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for pentazocine + paracetamol before they complete the sale. You can get this information while placing the order for pentazocine + paracetamol with the pharmacy.
Pentazocine + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for pentazocine + paracetamol might be better known than pentazocine + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have pentazocine + paracetamol in stock, you can ask for one of the branded alternatives for pentazocine + paracetamol.