Hydroflumethiazide Pharmacology

Hydroflumethiazide

About Hydroflumethiazide
An thiazide (benzothiadiazide) diuretic, Symporter inhibitor, Antihypertensive(Diuretic).
Mechanism of Action of Hydroflumethiazide
It is thiazide diuretic which exerts its action by acting at site-3(central dilating segment of early distal tubule). It binds to Na+Cl- symporter and inhibits Na+Cl- symport at the luminal membrane. It increases natriuresis, kaliuresis and diuresis. It decreases Ca2+ excretion and increases Mg2+excretion. It also has minor carbonic anhydrase inhibitory action. It also causes direct arteriolar vasodilatation and decreases total peripheral resistance. The antihypertensive actions of the drug may be attributable to depletion of sodium and subsequent reduction in plasma volume and a decrease in peripheral resistance. Decrease in peripheral resistance is due to either the loss of sodium from the arteriolar wall or a direct action on the vascular bed. It is an effective drug in edema associated with congestive heart failure.
Pharmacokinets of Hydroflumethiazide
N/A
Onset of Action for Hydroflumethiazide
2 hours
Duration of Action for Hydroflumethiazide
12-24 hours
Half Life of Hydroflumethiazide
N/A
Side Effects of Hydroflumethiazide
1.Hypokalemia
2.Dizziness
3.Fatigue
4.Frequent urination
5.Dry mouth
6.Anxiety
7.Muscle cramps
8.Nervousness
9.Nausea
10.Vomiting
11.Increase in blood sugar and uric acid levels
12.Allergic reactions
13.Abdominal disturbances
14.Anorexia
15.Constipation
16.Cough
17.Depression
18.Diarrhoea
19.Drowsiness
20.Hives
21.Impotence
22.Indigestion
23.Light-headedness
24. Rash
Contra-indications of Hydroflumethiazide
1.Hypersensitivity to Hydroflumethiazide
2.Anuria
3.Renal decompensation
Special Precautions while taking Hydroflumethiazide
1.Severe renal impairment
2.Electrolyte disturbances (hypokalemia, hypochloremic alkalosis, hyponatremia)
3.Severe hepatic impairment
4.Gout
5.Diabetics
6.SLE exacerbation or activation.
7.Hypercholesterolaemia
8.Photosensitization
9.Correct hypokalemia before initiating therapy.
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Hydroflumethiazide
1.Edema associated with congestive heart failure, hepatic cirrhosis, nephrotic syndrome, corticosteroid and oestrogen therapy
2.Hypertension
Interactions for Hydroflumethiazide
N/A
Typical Dosage for Hydroflumethiazide
Oral:
Adults:
Edema:
Initial dose: 50 mg to be taken 1-2 times a day
Maintenance dose: 25-200 mg / day
Hypertension:
Initial dose: 50 mg to be taken 2 times daily
Maintenance dose: 50-100 mg / day; maximum: 200 mg/day
Children: 1 mg / kg /day
Schedule of Hydroflumethiazide
N/A
Storage Requirements for Hydroflumethiazide
Store at room temperature in a well closed container and protected from light.
Effects of Missed Dosage of Hydroflumethiazide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.
Effects of Overdose of Hydroflumethiazide
Give supportive measures and symptomatic treatment.After gastric lavage, give I.V fluids, electrolyte and I.V.pressor if needed.

Home Delivery for Hydroflumethiazide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including hydroflumethiazide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for hydroflumethiazide and other medicines and health products. Home delivery services for hydroflumethiazide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take hydroflumethiazide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for hydroflumethiazide before they complete the sale. You can get this information while placing the order for hydroflumethiazide with the pharmacy.

Hydroflumethiazide is a generic medicine name and there are several brands available for it. Some of the brands for hydroflumethiazide might be better known than hydroflumethiazide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have hydroflumethiazide in stock, you can ask for one of the branded alternatives for hydroflumethiazide.