Sulphamethizole Pharmacology

Sulphamethizole

About Sulphamethizole
Short acting sulfonamide, In urinary tract infections.
Mechanism of Action of Sulphamethizole
Sulphamethizole is a sterile, sulfonamide which exerts its bacteriostatic action by inhibiting bacterial folate synthetase enzyme and results in inhibition of bacterial folic acid synthesis. Sulfonamides are structural analogues of PABA (Para amino benzoic acid) which is an essential constituent of bacterial folic acid. It competitively inhibits the incorporation of PABA with Pteridine residue to form dihydropteroic acid which conjugates with glutamic acid and produce Dihydrofolic acid. Also being chemically similar to PABA the sulfonamides may itself incorporated to form an altered folate which is metabolically injurious
Pharmacokinets of Sulphamethizole
Absorption: It is readily absorbed after oral administration.
Distribution: It is widely distributed in the body mainly in pleural, peritoneal, synovial, and ocular fluids.
Metabolism: It undergoes metabolism in the liver.
Excretion: It is excreted mainly through urine.
Onset of Action for Sulphamethizole
N/A
Duration of Action for Sulphamethizole
N/A
Half Life of Sulphamethizole
N/A
Side Effects of Sulphamethizole
1. Gastrointestinal disturbances
2. Headache
3. Convulsions
4. Vertigo
5. Crystalluria
6. Haematuria
7. Proteinuria
8. Fever
9. Chills
10. Alopecia
11. Myalgia
12. Agranulocytosis
13. Aplastic anaemia
14. Thrombocytopenia
15. Leukopenia
16. Megaloblastic anaemia
17. Rythema multiforme
18. Skin eruptions
Contra-indications of Sulphamethizole
1. Hypersensitivity to Sulphamethizole and other Sulphonamides
2. Porphyria
3. Blood dyscrasias
4. AIDS
Special Precautions while taking Sulphamethizole
1. Hepatic impairment
2. Renal impairment
3. Dehydration
4. Thyroid dysfunction
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: Contraindicated
Indications for Sulphamethizole
1. Urinary tract infection
Interactions for Sulphamethizole
Avoid concomitant use with methenamine.
Typical Dosage for Sulphamethizole
Adult: Adults -500 - 1000mg every 3 - 4 times daily.
Children: 2 months of age and older: 7.5 to 11.25 mg /kg body weight 4 times daily.

Schedule of Sulphamethizole
H
Storage Requirements for Sulphamethizole
Store at room temperature. Protect from heat, moisture and light. Keep out of the reach of children.
Effects of Missed Dosage of Sulphamethizole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Sulphamethizole
Give supportive measures and symptomatic treatment.

Home Delivery for Sulphamethizole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including sulphamethizole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for sulphamethizole and other medicines and health products. Home delivery services for sulphamethizole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take sulphamethizole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for sulphamethizole before they complete the sale. You can get this information while placing the order for sulphamethizole with the pharmacy.

Sulphamethizole is a generic medicine name and there are several brands available for it. Some of the brands for sulphamethizole might be better known than sulphamethizole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have sulphamethizole in stock, you can ask for one of the branded alternatives for sulphamethizole.