Tegaserod Pharmacology

Tegaserod

About Tegaserod
Serotonin 5-HT4 Agonist, A motility stimulant.
Mechanism of Action of Tegaserod
Tegaserod is a 5HT4 agonist with negligible affinity for other receptor subtypes. Binding of Tegaserod to the 5HT4 receptor will enhances gastrointestinal motility and accelerates transit time in the gastrointestinal tract. It also stimulates chloride secretions and reduces the sensitivity of the intestinal pain-sensing nerves and can thereby reduce the perception of pain.
Pharmacokinets of Tegaserod
Absorption: Tegaserod is partially absorbed from the gut after oral absorption
Distribution: It is distributed in highly protein bound form.
Metabolism: Tegaserod is metabolised to inactive metabolites in the liver by oxidation and glucuronidation
Excretion: most of the drug (2/3 rd of the administered drug) is excreted in faeces and the remains in urine
Onset of Action for Tegaserod
N/A
Duration of Action for Tegaserod
N/A
Half Life of Tegaserod
11 hours
Side Effects of Tegaserod
1. Abdominal pain
2. Diarrhoea
3. Headache
4. Nausea
5. Flatulence
6. Dizziness


Contra-indications of Tegaserod
1. Hypersensitivity to Tegaserod
2. Severe renal impairment
3. Severe hepatic impairment
4. Bowel obstruction
5. Symptomatic Gall bladder disease
6. Suspected sphincter of Oddi dysfunction

Special Precautions while taking Tegaserod
1. Diarrhoea
2. Discontinue the use of medicament if any discomfort occurs

Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
NEONATES: Contraindicated
Indications for Tegaserod
1. Chronic constipation
2. Irritable bowel syndrome with constipation in women

Interactions for Tegaserod
There was no effect on the pharmacokinetics of digoxin, oral contraceptives, and warfarin.
Dextromethorphan: A pharmacokinetic interaction study demonstrated that co-administration of tegaserod and dextromethorphan did not change the pharmacokinetics of either compound to a clinically relevant extent. Dose adjustment of either drug is not necessary when tegaserod is combined with dextromethorphan.
Theophylline: Co-administration of tegaserod and theophylline did not affect the pharmacokinetics of theophylline. Dose adjustment of theophylline is not necessary when tegaserod is co-administered.
Digoxin: Concomitant administration of tegaserod reduced peak plasma concentration and exposure of digoxin by approximately 15%.
Warfarin: No effect of concomitant administration of tegaserod on warfarin pharmacokinetics and pharmacodynamics. Dose adjustment of warfarin is not necessary when tegaserod is co-administered.
Oral Contraceptives: No alteration in oral contraceptive medication is necessary when tegaserod is co-administered.
Typical Dosage for Tegaserod
Adult: 12 mg / day in 2 divided doses before meals for 1 - 1? month and if sufficient response is obtained then continue the treatment for 1 - 1? month.


Schedule of Tegaserod
N/A
Storage Requirements for Tegaserod
Store at 15 - 30 degree C. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Tegaserod
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tegaserod
Give supportive measures and symptomatic treatment.

Home Delivery for Tegaserod in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tegaserod.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tegaserod and other medicines and health products. Home delivery services for tegaserod may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take tegaserod only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tegaserod before they complete the sale. You can get this information while placing the order for tegaserod with the pharmacy.

Tegaserod is a generic medicine name and there are several brands available for it. Some of the brands for tegaserod might be better known than tegaserod itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tegaserod in stock, you can ask for one of the branded alternatives for tegaserod.