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- Pharmacology For Cinchocaine+Hydrocortisone Topical+Framycetin
Cinchocaine+Hydrocortisone Topical+Framycetin Pharmacology
Cinchocaine+Hydrocortisone Topical+Framycetin
About Cinchocaine+Hydrocortisone Topical+FramycetinN/AMechanism of Action of Cinchocaine+Hydrocortisone Topical+FramycetinN/APharmacokinets of Cinchocaine+Hydrocortisone Topical+FramycetinN/AOnset of Action for Cinchocaine+Hydrocortisone Topical+FramycetinN/ADuration of Action for Cinchocaine+Hydrocortisone Topical+FramycetinN/AHalf Life of Cinchocaine+Hydrocortisone Topical+FramycetinN/ASide Effects of Cinchocaine+Hydrocortisone Topical+FramycetinN/AContra-indications of Cinchocaine+Hydrocortisone Topical+FramycetinN/ASpecial Precautions while taking Cinchocaine+Hydrocortisone Topical+FramycetinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Cinchocaine+Hydrocortisone Topical+FramycetinN/AInteractions for Cinchocaine+Hydrocortisone Topical+FramycetinN/ATypical Dosage for Cinchocaine+Hydrocortisone Topical+FramycetinN/ASchedule of Cinchocaine+Hydrocortisone Topical+FramycetinN/AStorage Requirements for Cinchocaine+Hydrocortisone Topical+FramycetinN/AEffects of Missed Dosage of Cinchocaine+Hydrocortisone Topical+FramycetinN/AEffects of Overdose of Cinchocaine+Hydrocortisone Topical+FramycetinN/ACinchocaine
About CinchocaineAn amide derivative, most potent and toxic long-acting local anesthetics, A local anaestheticMechanism of Action of CinchocaineCinchocaine is a local anesthetic. It works by blocking the pathway of pain signals along nerves. It inhibits conduction of nerve impulses and decreases cell membrane permeability to ions at the site of the pain. This prevents an electrical signal building up and passing along the nerve fibres to the brain. In this way Cinchocaine causes numbness and relieves pain at the area it is applied to.
Pharmacokinets of CinchocaineAbsorption:It has limited absorptionOnset of Action for CinchocaineN/ADuration of Action for CinchocaineN/AHalf Life of CinchocaineN/ASide Effects of Cinchocaine1. Irritation of the back passage
2. Inflammation
3. Contact dermatitis
4. Skin rashes
5. Urticaria
6. Burning
7. Stinging
Contra-indications of Cinchocaine1.Hypersensitivity to Cinchocaine, Sulfites or other amide type local anesthetics
2.Use in large skin areas, broken skin or mucous membrane
3.Infection
Special Precautions while taking Cinchocaine1.This medicine should not be used for longer than seven days at a time.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Cinchocaine1.Relief of pain and itching associated with abrasions, sunburn, minor burn, insect bites and other minor skin conditions
2.Piles (hemorrhoids)
3. Anal itch
Interactions for CinchocaineN/ATypical Dosage for CinchocaineApply to the affected area whenever necessary.
Maximum daily dose:30g for adult and 7.5g for children
Schedule of CinchocaineN/AStorage Requirements for CinchocaineSuppository:should be stored in a refrigerator (2-8?C).
Cream:should be stored at room temperature. Keep all medicines out of the reach of children.Effects of Missed Dosage of CinchocaineApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.Effects of Overdose of CinchocaineClean area thoroughly with mild soap and waterHydrocortisone Topical
About Hydrocortisone TopicalTopical synthetic glucocorticoid, anti-inflammatory and anti-pruritic.Mechanism of Action of Hydrocortisone TopicalThe drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts both glucocorticoid and mineralocorticoid actions.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Hydrocortisone TopicalAbsorption: Absorption ranges from 1% to 36% after topical application.
Distribution: Distributed throughout the local skin layers. Any drug absorbed in to circulation is rapidly removed from blood and distributed in to muscle, liver, kidney, skin, and intestine.
Metabolism: Metabolized primarily in skin and a small amount absorbed is metabolized in liver.
Excretion: Metabolites are excreted mainly through urine and a small amount is excreted through faeces.
Onset of Action for Hydrocortisone TopicalN/ADuration of Action for Hydrocortisone TopicalN/AHalf Life of Hydrocortisone TopicalN/ASide Effects of Hydrocortisone Topical1. Burning
2. Irritation
3. Pruritus
4. Dryness
5. Erythema
6. Folliculitis
7. Hypertrichosis
8. Acneiform eruptions
9. Allergic contact dermatitis
10. Secondary infections
11. Atrophy
12. Striae
Contra-indications of Hydrocortisone Topical1. Hypersensitivity to the drug
2. Local or systemic infections
3. Fungal or herpetic keratitis
4. Cataract
5. Tubercular or syphilitic lesions
Special Precautions while taking Hydrocortisone Topical1. Occlusive dressings
2. Use of potent preparations should be short term or intermittent
3. Milder drugs should be used in acute lesions and stronger ones are for chronic lesions
4. Avoid sudden discontinuation of the drug.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Hydrocortisone Topical1. Treatment of skin disorders: Dermatitis, Eczema,Psoriasis
2. Inflammations of corticosteroid-responsive dermatoses
3. Seborrheic dermatitis of scalp
Interactions for Hydrocortisone TopicalCarbamazepine, Primidone: Decreases efficacy.
Oral contraceptives: Increase concentration of hydrocortisone.
Oestrogens: Decreases clearance of hydrocortisone.
Ketoconazole: Decreases clearance of hydrocortisone.
Rifampicin: Decreases efficacy.
Hydrocortisone effects the actions of the following:
Anticholinesterases: Efficacy antagonised in myasthenia gravis.
Oral anticoagulants: Altered response.
Cyclosporine: Increases efficacy, enhanced toxicity may occur.
Digitalis glycosides: May enhance toxicity.
Isoniazid: Decreases serum levels.
Salicylates: Decreases serum levels.
Diuretics (K sparing): May cause hypokalaemia.
Non-depolarising muscle relaxants: Altered response of either agent may occur.
Somatrem: Growth promoting effect inhibited.
Theophyllines: Altered response of either agent.
Lab. Tests: Increases serum cholesterol levels. Increases urine glucose levels. Decreases Thyroid I131 uptake; Decreases T3 serum levels. Decreases serum potassium.Typical Dosage for Hydrocortisone TopicalCream:
Apply 0.1% to 2.5% 1 to 4 times daily.
Ointment:
0.5% to 2.5% Apply 1 to 4 times as required
Lotion:
0.25% to 2.5% Apply 1 to 4 times as required
Gel:
0.5% to 1% Apply 1 to 4 times as required
Aerosol:
Seborrheic dermatitis of scalp:
0.5% to 1%Apply for only 3seconds. Directly spray in to the affected area from 15 cm apart. No need for massage or rub. Apply 1 to 4 times daily until acute phase is controlled. Then reduce the dosage to 0nce to thrice weekly.
Schedule of Hydrocortisone TopicalHStorage Requirements for Hydrocortisone TopicalStore at room temperature at a range of 15 to 30 degree C. Protect from light and moisture. Keep out of reach of children.Effects of Missed Dosage of Hydrocortisone TopicalApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Hydrocortisone TopicalProvide symptomatic treatment and supportive measures.Framycetin
About FramycetinAminoglycoside antibiotic.Mechanism of Action of FramycetinFramycetin exerts its bactericidal action by inhibiting bacterial protein synthesis. The process involves 1 Penetration of bacterial cell membrane & binding directly to the bacterial ribosome, 2.Misleading of m-RNA codon by bacterial ribosome, 3.Formation of peptide chains with wrong amino acid sequence which gets incorporated into bacterial cell membrane and alters its permeability, 4.Bacterial cell lysis. Framycetin works by killing the bacteria that causes eye infection.
Putting the drops directly into the eye allows the Framycetin to act directly on the bacteria which produces infection.Pharmacokinets of FramycetinAbsorption of the drug after topical use is minimalOnset of Action for FramycetinN/ADuration of Action for FramycetinN/AHalf Life of FramycetinN/ASide Effects of Framycetin1.Eye irritation
2.Eye stinging
3.Itching
Contra-indications of FramycetinHypersensitivity to SoframycinSpecial Precautions while taking Framycetin1.Prolonged use
2.If irritation occurs then discontinue the use of medicaments
3.Avoid contact lenses
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for FramycetinBacterial infections of skin
Burns
Wounds
Ulcers
Interactions for FramycetinN/ATypical Dosage for FramycetinEye drops: Apply2-3 drops to affected eye 3-4times daily, or at bedtime.
Serious eye infections: Apply 1 - 2 drops to affected eye every 1-2 hours for 2-3 days and then reduce the frequency to 3 -4 times daily.
Do not use more than 1 month after opening.
Framycetin Eye Ointment:
2-3 applications of the ointment in the eye daily, or at bedtime if eye drops have been used during the day.
Schedule of FramycetinN/AStorage Requirements for FramycetinStore at cool dry place. Protect from light. Do not freeze. Keep out of the reach of children. Avoid use of medicament 1 month after openingEffects of Missed Dosage of FramycetinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of FramycetinGive supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of warm water for at least 15 minutes.Home Delivery for Cinchocaine+Hydrocortisone Topical+Framycetin in Your City
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