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- Pharmacology For Lignocaine+Hydrocortisone Topical+Calcium dobesilate
Lignocaine+Hydrocortisone Topical+Calcium dobesilate Pharmacology
Lignocaine+Hydrocortisone Topical+Calcium dobesilate
About Lignocaine+Hydrocortisone Topical+Calcium dobesilateN/AMechanism of Action of Lignocaine+Hydrocortisone Topical+Calcium dobesilateN/APharmacokinets of Lignocaine+Hydrocortisone Topical+Calcium dobesilateN/AOnset of Action for Lignocaine+Hydrocortisone Topical+Calcium dobesilateN/ADuration of Action for Lignocaine+Hydrocortisone Topical+Calcium dobesilateN/AHalf Life of Lignocaine+Hydrocortisone Topical+Calcium dobesilateN/ASide Effects of Lignocaine+Hydrocortisone Topical+Calcium dobesilateN/AContra-indications of Lignocaine+Hydrocortisone Topical+Calcium dobesilateN/ASpecial Precautions while taking Lignocaine+Hydrocortisone Topical+Calcium dobesilateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Lignocaine+Hydrocortisone Topical+Calcium dobesilateN/AInteractions for Lignocaine+Hydrocortisone Topical+Calcium dobesilateN/ATypical Dosage for Lignocaine+Hydrocortisone Topical+Calcium dobesilateN/ASchedule of Lignocaine+Hydrocortisone Topical+Calcium dobesilateN/AStorage Requirements for Lignocaine+Hydrocortisone Topical+Calcium dobesilateN/AEffects of Missed Dosage of Lignocaine+Hydrocortisone Topical+Calcium dobesilateN/AEffects of Overdose of Lignocaine+Hydrocortisone Topical+Calcium dobesilateN/ALignocaine
About LignocaineLincosamide antibiotic , Antibiotic.Mechanism of Action of LignocaineN/APharmacokinets of LignocaineN/AOnset of Action for LignocaineN/ADuration of Action for LignocaineN/AHalf Life of LignocaineN/ASide Effects of LignocaineN/AContra-indications of LignocaineN/ASpecial Precautions while taking LignocaineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for LignocaineN/AInteractions for LignocaineN/ATypical Dosage for LignocaineN/ASchedule of LignocaineN/AStorage Requirements for LignocaineN/AEffects of Missed Dosage of LignocaineN/AEffects of Overdose of LignocaineN/AHydrocortisone Topical
About Hydrocortisone TopicalTopical synthetic glucocorticoid, anti-inflammatory and anti-pruritic.Mechanism of Action of Hydrocortisone TopicalThe drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts both glucocorticoid and mineralocorticoid actions.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Hydrocortisone TopicalAbsorption: Absorption ranges from 1% to 36% after topical application.
Distribution: Distributed throughout the local skin layers. Any drug absorbed in to circulation is rapidly removed from blood and distributed in to muscle, liver, kidney, skin, and intestine.
Metabolism: Metabolized primarily in skin and a small amount absorbed is metabolized in liver.
Excretion: Metabolites are excreted mainly through urine and a small amount is excreted through faeces.
Onset of Action for Hydrocortisone TopicalN/ADuration of Action for Hydrocortisone TopicalN/AHalf Life of Hydrocortisone TopicalN/ASide Effects of Hydrocortisone Topical1. Burning
2. Irritation
3. Pruritus
4. Dryness
5. Erythema
6. Folliculitis
7. Hypertrichosis
8. Acneiform eruptions
9. Allergic contact dermatitis
10. Secondary infections
11. Atrophy
12. Striae
Contra-indications of Hydrocortisone Topical1. Hypersensitivity to the drug
2. Local or systemic infections
3. Fungal or herpetic keratitis
4. Cataract
5. Tubercular or syphilitic lesions
Special Precautions while taking Hydrocortisone Topical1. Occlusive dressings
2. Use of potent preparations should be short term or intermittent
3. Milder drugs should be used in acute lesions and stronger ones are for chronic lesions
4. Avoid sudden discontinuation of the drug.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Hydrocortisone Topical1. Treatment of skin disorders: Dermatitis, Eczema,Psoriasis
2. Inflammations of corticosteroid-responsive dermatoses
3. Seborrheic dermatitis of scalp
Interactions for Hydrocortisone TopicalCarbamazepine, Primidone: Decreases efficacy.
Oral contraceptives: Increase concentration of hydrocortisone.
Oestrogens: Decreases clearance of hydrocortisone.
Ketoconazole: Decreases clearance of hydrocortisone.
Rifampicin: Decreases efficacy.
Hydrocortisone effects the actions of the following:
Anticholinesterases: Efficacy antagonised in myasthenia gravis.
Oral anticoagulants: Altered response.
Cyclosporine: Increases efficacy, enhanced toxicity may occur.
Digitalis glycosides: May enhance toxicity.
Isoniazid: Decreases serum levels.
Salicylates: Decreases serum levels.
Diuretics (K sparing): May cause hypokalaemia.
Non-depolarising muscle relaxants: Altered response of either agent may occur.
Somatrem: Growth promoting effect inhibited.
Theophyllines: Altered response of either agent.
Lab. Tests: Increases serum cholesterol levels. Increases urine glucose levels. Decreases Thyroid I131 uptake; Decreases T3 serum levels. Decreases serum potassium.Typical Dosage for Hydrocortisone TopicalCream:
Apply 0.1% to 2.5% 1 to 4 times daily.
Ointment:
0.5% to 2.5% Apply 1 to 4 times as required
Lotion:
0.25% to 2.5% Apply 1 to 4 times as required
Gel:
0.5% to 1% Apply 1 to 4 times as required
Aerosol:
Seborrheic dermatitis of scalp:
0.5% to 1%Apply for only 3seconds. Directly spray in to the affected area from 15 cm apart. No need for massage or rub. Apply 1 to 4 times daily until acute phase is controlled. Then reduce the dosage to 0nce to thrice weekly.
Schedule of Hydrocortisone TopicalHStorage Requirements for Hydrocortisone TopicalStore at room temperature at a range of 15 to 30 degree C. Protect from light and moisture. Keep out of reach of children.Effects of Missed Dosage of Hydrocortisone TopicalApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Hydrocortisone TopicalProvide symptomatic treatment and supportive measures.Calcium Dobesilate
About Calcium DobesilateAntithrombotic, vasoprotective.Mechanism of Action of Calcium DobesilateIt acts on capillary and venous walls and decreases increased capillary and venous permeability and fragility and improves decreased resistance. Thus exerting an anti edematous and protective action on blood vessels. It increases endothelial nitric oxide levels by enhancing the activity of nitric oxide synthase. It acts on endothelial layer and basement membrane of capillaries and decreases histamine and bradykinin induced hyperpermeability. It prevents breakdown of collagen and reduce viscosity of blood and plasma and improves blood flow & prevents stasis but accelerates type-2 collagen fibrinogenesis a major structural component of arterial wall. It exerts antiplatelet and fibrinolytic actions by inhibiting platelet activation factor and enhancing the release of tissue plasminogen activator & hence improves blood flow to tissues. It decreases platelet aggregation stimulated by collagen and thrombin and antiplatelet action counteract thrombosis. It inhibits two pathophysiological reactions in diabetes viz. polyol pathway and glycation of proteins by inhibitory effects on aldose reductase. It also inhibits formation of sorbitol.Pharmacokinets of Calcium DobesilateAbsorption: Well absorbed orally
Distribution: Widely distributed in to the body
Metabolism: A portion is metabolized in kidneys
Excretion: Excreted through urine and faeces
Onset of Action for Calcium DobesilateN/ADuration of Action for Calcium DobesilateN/AHalf Life of Calcium Dobesilate2 to 8hoursSide Effects of Calcium Dobesilate1.Gastro intestinal irritation
2.Nausea
3.Vomiting
4.Diarrhoea
5.Rash
6.Pruritus
7.Fever.
Contra-indications of Calcium Dobesilate1.Hypersensitivity to the drugSpecial Precautions while taking Calcium Dobesilate1.Renal impairment
2.Duodenal ulcer
3.Peptic ulcer
4.Gastritis
5.Allergic manifestations such as rashes, Pruritus, fever etc.
Pregnancy Related InformationMay be used
First trimester: contraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicatedIndications for Calcium Dobesilate1.Diabetic retinopathy
2.Micro angiopathy
3.Varicose veins
4.Haemorrhoids
5.Myocardial infarction.
Interactions for Calcium DobesilateN/ATypical Dosage for Calcium DobesilateDiabetic retinopathy and micro angiopathy:
500mg to1000mg/day in two divided doses for 4 to 6months followed by 500mg once daily.
Varicose veins and Haemorrhoids:
500mg 12th hourly up to 3 weeks followed by 500mg once daily
Prevention of secondary myocardial infarction:
500mg/day
Schedule of Calcium DobesilateHStorage Requirements for Calcium DobesilateStore in well closed container and protected from light and moisture. Keep out of reach of childrenEffects of Missed Dosage of Calcium DobesilateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Calcium DobesilateTreatment is supportive and symptomatic. Perform induced emesis and gastric lavage.Home Delivery for Lignocaine+Hydrocortisone Topical+Calcium dobesilate in Your City
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