Loperamide + Simethicone Pharmacology

Loperamide + Simethicone

About Loperamide + Simethicone
N/A
Mechanism of Action of Loperamide + Simethicone
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Pharmacokinets of Loperamide + Simethicone
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Onset of Action for Loperamide + Simethicone
N/A
Duration of Action for Loperamide + Simethicone
N/A
Half Life of Loperamide + Simethicone
N/A
Side Effects of Loperamide + Simethicone
N/A
Contra-indications of Loperamide + Simethicone
N/A
Special Precautions while taking Loperamide + Simethicone
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
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Indications for Loperamide + Simethicone
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Interactions for Loperamide + Simethicone
N/A
Typical Dosage for Loperamide + Simethicone
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Schedule of Loperamide + Simethicone
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Storage Requirements for Loperamide + Simethicone
N/A
Effects of Missed Dosage of Loperamide + Simethicone
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Effects of Overdose of Loperamide + Simethicone
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Loperamide

About Loperamide
A synthetic piperidine derivative, Opioid, Antidiarrhoeal, Analgesic.
Mechanism of Action of Loperamide
Loperamide is a mu receptor agonist. It inhibits the release of Acetylcholine on myenteric plexus in the gastrointestinal tract. This results in slowing intestinal motility and reduces peristalsis and increase intestinal transit time. This will results in increased absorption of water from fecal matter. Loperamide also has a direct action on intestinal smooth muscle. It does not have any effect on central nervous system.
Pharmacokinets of Loperamide
Absorption: Loperamide is poorly absorbed after oral administration
Distribution: It is widely distributed mainly in protein bound form
Metabolism: Absorbed drug undergoes metabolism in the liver
Excretion: It is excreted mainly in the faeces and small amount in the urine.
Onset of Action for Loperamide
1 - 2 hours.
Duration of Action for Loperamide
1 day
Half Life of Loperamide
7 - 14 hours
Side Effects of Loperamide
1.Dry mouth
2.Abdominal pain
3.Nausea
4.Vomiting
5.Gastric discomfort
6.Drowsiness
7.Dizziness
8.Tiredness
9.Constipation
10.Allergic reaction
11.Toxic megacolon
Contra-indications of Loperamide
1.Hypersensitivity to Loperamide
2.Severe diarrhoea where inhibition of peristalsis is not desirable
3.Fever
4.Bloody stool diarrhoea
5.Pseudomembranous enterocolitis
Special Precautions while taking Loperamide
1.Hepatic impairment
2.Acute ulcerative colitis
3.Crohn`s disease
4.Intestinal stasis
5.Pyloric obstruction
6.Urinary bladder neck obstruction
7.Gastric retentions
8.Use caution while driving vehicle or operating machine or performing activities requiring mental alertness
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Below 2 years: contraindicated
NEONATES: contraindicated
Indications for Loperamide
1.Diarrhoea
Interactions for Loperamide
N/A
Typical Dosage for Loperamide
Adult (Oral): Initial dose: 4 mg followed by 2 mg after each loose motion. Maintenance dose: 6 - 8 mg daily
Maximum dose: 16 mg / day
Children:
2 - 5 years: 3 mg / day in 3 divided doses
6 - 8 years: 4 mg / day in 2 divided doses
8 - 12 years: 6 mg / day in 3 divided doses
Schedule of Loperamide
H
Storage Requirements for Loperamide
Store the drug at 15 - 30 degree C in a tightly closed container. Protect from heat and light.
Effects of Missed Dosage of Loperamide
Do not apply if it is taken as to control diarrhoea.
If it is taken as a regular schedule then take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Loperamide
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage. Absorption of the drug can be reduced by administration of activated charcoal. Respiratory depression can be treated with Naloxone.

Simethicone

About Simethicone
Oral anti-foaming agent, Silicones, Antiflatulent.
Mechanism of Action of Simethicone
This anti-gas (anti-flatulence) medication acts in the stomach and intestines to change the surface tension of gas bubbles, enabling smaller bubbles to join together into bigger bubbles. It results elimination of gas more easily by belching or passing flatus.
Pharmacokinets of Simethicone
Excretion- Excreted through feces.
Onset of Action for Simethicone
N/A
Duration of Action for Simethicone
N/A
Half Life of Simethicone
N/A
Side Effects of Simethicone
1. Bloating
2. Constipation
3. Diarrhea
4. Gas
5. Heartburn
Contra-indications of Simethicone
1. Hypersensitivity to the drug
2. Liver disease
3. Kidney disease
4. Serious illness
Special Precautions while taking Simethicone
1.Swallow the tablets and capsules with a full glass of water.
2.Chew the chewable tablets thoroughly before swallowing.
3.Shake the drops well before using them.
4.To make administration easier, the drops can be mixed with 30 ml (2 tablespoons) of water or another liquid.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Simethicone
1. Abdominal pain which is due to excessive gas in the digestive tract
2. Before gastroscopy or radiography of the bowel
Interactions for Simethicone
N/A
Typical Dosage for Simethicone
Oral-
Adults and teenagers-
60 -125mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Chewable tablets:
Adults and teenagers-
40 -125 mg four times a day, after meals and at bedtime or 150 mg three times a day, after meals. Not more than 500 mg should be taken in twenty-four hours.
Suspension:
Adults and teenagers-
40 -95 mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Schedule of Simethicone
N/A
Storage Requirements for Simethicone
Stored at room temperature (15-30?C) away from moisture and heat.
Effects of Missed Dosage of Simethicone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Simethicone
Give symptomatic and supportive treatment.

Home Delivery for Loperamide + Simethicone in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for loperamide + simethicone and other medicines and health products. Home delivery services for loperamide + simethicone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take loperamide + simethicone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for loperamide + simethicone before they complete the sale. You can get this information while placing the order for loperamide + simethicone with the pharmacy.

Loperamide + Simethicone is a generic medicine name and there are several brands available for it. Some of the brands for loperamide + simethicone might be better known than loperamide + simethicone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have loperamide + simethicone in stock, you can ask for one of the branded alternatives for loperamide + simethicone.