Dextropropoxyphene Pharmacology

Dextropropoxyphene

About Dextropropoxyphene
A synthetic morphine derivative,Opioid-like agonist,optical isomer of Levopropoxyphene, Narcotic Analgesic, anti-tussive and local anesthetic.
Mechanism of Action of Dextropropoxyphene
It acts on the CNS Opioid receptors. It has agonist action on mu Opioid receptors. It primarily binds to the mu Opioid receptors and produce analgesia. Its CNS effects are same as morphine. It gives in combination with other Non Steroidal Anti Inflammatory Drugs or other analgesics usually.
Pharmacokinets of Dextropropoxyphene
Absorption-Orally absorbed; primarily to the upper small intestine.
Distribution-Widely distributed in the body. Enters the cerebrospinal fluid and cross the placenta.
Metabolism-In liver it is metabolized by N-demethylation. Norpropoxyphene is its active metabolite. It has more half life than parent drug. It causes toxicity at sometime due to its metabolites accumulation in the body.
Excretion-It is excreted through urine.
Onset of Action for Dextropropoxyphene
30 to 60 min. after oral administration
Duration of Action for Dextropropoxyphene
4 to 6 hrs
Half Life of Dextropropoxyphene
Plasma half life is 6 to 12 hrs
Side Effects of Dextropropoxyphene
1. Nausea
2. Vomiting
3. Epigastric distress
4. Sedation
5. Dizziness
6. Urticaria
7. Visual disturbances
8. Physiological dependence
Contra-indications of Dextropropoxyphene
1. Hypersensitivity to this drug
2. Respiratory depression
3. Children below 12 years
Special Precautions while taking Dextropropoxyphene
1. In patients with hepatic failure or renal failure used cautiously
2. Patient can not drive or operate machinery after the drug administration. So the care should be taken
3. Use cautiously in patients with suicidal mentality
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Dextropropoxyphene
1. Relieve moderate to severe pain in various conditions
2. Opioid withdrawal
Interactions for Dextropropoxyphene
Barbiturate anaesthetics: May increase respiratory and CNS depressive effects of propoxyphene.
Warfarin: Potentiation of hypoprothrombinemic effect.
Carbamazipine: May increase serum carbamzipine levels with resultant toxicity.
Typical Dosage for Dextropropoxyphene
Oral-
Adults - 65mg 3 to 4 times daily.
Schedule of Dextropropoxyphene
H
Storage Requirements for Dextropropoxyphene
Store controlled room temperature i.e. between 15 and 30 degree Celsius
Effects of Missed Dosage of Dextropropoxyphene
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dextropropoxyphene
Provide supportive and symptomatic treatment. Establish artificial respiratory exchange. In the case of respiratory or cardiovascular depression administer a narcotic antagonist i.e. naloxone.Induce emesis or gastric lavage if the patient shows symptoms within 2hrs after drug administration. Avoid the risk of aspiration. For the further removal of drug, administer activated charcoal via nasogastric tube. Continue the supportive treatment and closely monitor the laboratory parameters, vital signs, neurological status closely. In some cases dialysis may be helpful for the treatment.

Home Delivery for Dextropropoxyphene in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dextropropoxyphene.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dextropropoxyphene and other medicines and health products. Home delivery services for dextropropoxyphene may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dextropropoxyphene only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dextropropoxyphene before they complete the sale. You can get this information while placing the order for dextropropoxyphene with the pharmacy.

Dextropropoxyphene is a generic medicine name and there are several brands available for it. Some of the brands for dextropropoxyphene might be better known than dextropropoxyphene itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dextropropoxyphene in stock, you can ask for one of the branded alternatives for dextropropoxyphene.