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- Pharmacology For Ofloxacin + Ornidazole + Lactobacillus
Ofloxacin + Ornidazole + Lactobacillus Pharmacology
Ofloxacin + Ornidazole + Lactobacillus
About Ofloxacin + Ornidazole + LactobacillusN/AMechanism of Action of Ofloxacin + Ornidazole + LactobacillusN/APharmacokinets of Ofloxacin + Ornidazole + LactobacillusN/AOnset of Action for Ofloxacin + Ornidazole + LactobacillusN/ADuration of Action for Ofloxacin + Ornidazole + LactobacillusN/AHalf Life of Ofloxacin + Ornidazole + LactobacillusN/ASide Effects of Ofloxacin + Ornidazole + LactobacillusN/AContra-indications of Ofloxacin + Ornidazole + LactobacillusN/ASpecial Precautions while taking Ofloxacin + Ornidazole + LactobacillusN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ofloxacin + Ornidazole + LactobacillusN/AInteractions for Ofloxacin + Ornidazole + LactobacillusN/ATypical Dosage for Ofloxacin + Ornidazole + LactobacillusN/ASchedule of Ofloxacin + Ornidazole + LactobacillusN/AStorage Requirements for Ofloxacin + Ornidazole + LactobacillusN/AEffects of Missed Dosage of Ofloxacin + Ornidazole + LactobacillusN/AEffects of Overdose of Ofloxacin + Ornidazole + LactobacillusN/AOfloxacin
About OfloxacinA second generation fluoroquinolone(quinolones), Antibiotic.Mechanism of Action of OfloxacinOfloxacin is a bactericidal drug. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Ofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.Pharmacokinets of OfloxacinAbsorption: Ofloxacin is rapidly and completely absorbed after oral administration.
Distribution: It is widely distributed in the body.
Metabolism: It undergoes insignificant metabolism.
Excretion: Drug is excreted mainly through urine.
Onset of Action for OfloxacinWith in 0.5 hour Duration of Action for Ofloxacin12 - 16 hoursHalf Life of Ofloxacin5 - 8 hoursSide Effects of Ofloxacin1. Nausea
2. Vomiting
3. Diarrhoea
4. Abdominal discomfort
5. Constipation
6. Dry mouth
7. Dizziness
8. Headache
9. Rash
10. Pruritis
11. Pseudomembranous colitis
12. Visual disturbances
13. Insomnia
Contra-indications of Ofloxacin1. Hypersensitivity to Ofloxacin and other FluoroquinolonesSpecial Precautions while taking Ofloxacin1. Hepatic impairment
2. Renal impairment
3. Cerebral arteriosclerosis
4. Epilepsy
5. CNS disease
6. Avoid exposure to sunlight
7. Caution while driving the vehicle or operating machine or involved in any hazardous activities.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES : Contraindicated
Indications for Ofloxacin1. Bronchitis
2. Pneumonia
3. Urinary tract infection
4. Bone and joint infections
5. Intra-abdominal infections
6. Gonorrhoea
7. ENT infections
8. Skin and soft tissue infections
9. Typhoid fever
10. Prostatis
11. Otitis
12. Gynaecological infections
13. Conjunctivitis
14. Keratitis
15. Urethritis
16. CervicitisInteractions for OfloxacinOral Anticoagulants: The effects of oral anticoagulants, may be increased.
Theophylline: Increased plasma levels of theophylline resulting in toxicity.
NSAID`s: CNS excitation may occur.Typical Dosage for OfloxacinAdults: 200 - 400 mg / day depending on the severity and type of infection
Bronchitis, Pneumonia, Skin and soft tissue infections: 800 mg / day in 2 divided doses for 10 days
Gonorrhoea: 400 mg as a single dose.
Prostatis, Cervicitis & Urethritis: 600 mg / day in 2 divided doses for 1 week.
UTI: 200 - 800 mg / day in single or divided doses
Typhoid fever: 400 - 800 mg / day in 2 divided doses
Schedule of OfloxacinHStorage Requirements for OfloxacinStore at 15 - 30 degree C in a tightly closed container.Effects of Missed Dosage of OfloxacinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of OfloxacinGive supportive measures and symptomatic treatment. Gastric lavage has to be done. Ornidazole
About OrnidazoleA nitro imidazole derivative, Antiprotozoal antibiotic,Antimicrobial.Mechanism of Action of OrnidazoleOrnidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization &strand breakage has been observed.
Pharmacokinets of OrnidazoleAbsorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by conjugation, Excretion: Excreted in urine and small portion is excreted in bile
Onset of Action for OrnidazoleWithin 2 hoursDuration of Action for Ornidazole14hoursHalf Life of Ornidazole12 to 14 hoursSide Effects of Ornidazole1.Abdominal pain
2.Vertigo
3.Nausea
4.Vomiting
5.Fatigue
6.Dry mouth
7.Headache
8.Rash
9.Urticaria
10.Abdominal distress
11.Dizziness
12.VertigoContra-indications of Ornidazole1.Hypersensitivity to the drug or other imidazolesSpecial Precautions while taking Ornidazole1.Vertigo
2.Mental confusion
3.Ataxia
Pregnancy Related InformationUse with caution
First trimester: contra indicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Ornidazole1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Anaerobic bacterial infections
5.Bacterial vaginosis
Interactions for OrnidazoleN/ATypical Dosage for OrnidazoleAmoebiasis:
Adults: 1gm daily in 2 divided doses for 7 to 10 days
Children: 10 to 25mg/kg once daily for 3days
Amoebic dysentery:
Adults: 1.5gm once daily for 3 days
Children: 40mg/kg once daily for 3 days
Trichomoniasis
Adults: 1.5gm single daily dose or 0.5gm 12hourly for 5 days,
Male partner should be concurrently treated.
Children: 25mg/kg as a single dose
Giardiasis:
Adults: 1 to 1.5gm once daily for 2days
Children: 40mg/kg for 2days
Bacterial vaginosis: 1.5gm once or 500mg once daily for 5 to7 days
Schedule of OrnidazoleHStorage Requirements for OrnidazoleStore at cool dry place. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of OrnidazoleTake the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of OrnidazoleTreatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics. Lactobacillus
About LactobacillusLactic acid bacteria, Probiotic,Antidiarrhoeal.Mechanism of Action of LactobacillusLactobacillus is a probiotic and it is called as friendly bacteria. It is used along with antibiotic in order to restore the body`s natural microbial flora with in the digestive tract. Lactobacillus helps in the breakdown of food and leads to the production of lactic acid, hydrogen peroxide and other byproducts. This will alter the intestinal pH and that make the environment hostile for pathogens.Pharmacokinets of LactobacillusAbsorption: It is orally well absorbed after oral administration.
Onset of Action for LactobacillusN/ADuration of Action for LactobacillusN/AHalf Life of LactobacillusN/ASide Effects of Lactobacillus1.Abdominal discomfort
2.Vaginal irritation (when used vaginally)
Contra-indications of Lactobacillus1.Recent bowel surgery
2.Intestinal damage
3.Weakened immune system
Special Precautions while taking LactobacillusPatient on Inulin treatmentPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: Use with cautionIndications for Lactobacillus1.Aphthous stomatitis
2.Hypochlorhydria
3.Hepatic encephalopathy
4.Adjuvant to antibiotic therapy
5.Diarrhoea.Interactions for LactobacillusN/ATypical Dosage for LactobacillusAdult: 60 - 150 million spores 3 times daily depending on the severity of infections.
Vaginal bacterial infections: 1- 2 billion bacteria 2 - 3 times daily
Suppositories:
Vaginal infections, cystitis: 1 - 2 suppositories are inserted in to vagina at night for 2 weeks. Each suppository contains 1 - 2 billion lactobacilli
Schedule of LactobacillusN/AStorage Requirements for LactobacillusRefrigerate below 5 degree C.Effects of Missed Dosage of LactobacillusN/AEffects of Overdose of LactobacillusGive supportive measures and symptomatic treatmentHome Delivery for Ofloxacin + Ornidazole + Lactobacillus in Your City
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