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- Pharmacology For Metronidazole + Furazolidone + Simethicone
Metronidazole + Furazolidone + Simethicone Pharmacology
Metronidazole + Furazolidone + Simethicone
About Metronidazole + Furazolidone + SimethiconeN/AMechanism of Action of Metronidazole + Furazolidone + SimethiconeN/APharmacokinets of Metronidazole + Furazolidone + SimethiconeN/AOnset of Action for Metronidazole + Furazolidone + SimethiconeN/ADuration of Action for Metronidazole + Furazolidone + SimethiconeN/AHalf Life of Metronidazole + Furazolidone + SimethiconeN/ASide Effects of Metronidazole + Furazolidone + SimethiconeN/AContra-indications of Metronidazole + Furazolidone + SimethiconeN/ASpecial Precautions while taking Metronidazole + Furazolidone + SimethiconeN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Metronidazole + Furazolidone + SimethiconeN/AInteractions for Metronidazole + Furazolidone + SimethiconeN/ATypical Dosage for Metronidazole + Furazolidone + SimethiconeN/ASchedule of Metronidazole + Furazolidone + SimethiconeN/AStorage Requirements for Metronidazole + Furazolidone + SimethiconeN/AEffects of Missed Dosage of Metronidazole + Furazolidone + SimethiconeN/AEffects of Overdose of Metronidazole + Furazolidone + SimethiconeN/AMetronidazole
About MetronidazoleA nitroimidazole antibiotic, Anti-infective, Antiprotozoal,amebicide.Mechanism of Action of MetronidazoleMetronidazole is nitro imidazoles which have broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which exerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization & strand breakage has been observed.Pharmacokinets of MetronidazoleAbsorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by oxidation & glucuronide conjugation, Excretion: Excreted in urine.
Onset of Action for Metronidazole1 to 2 daysDuration of Action for Metronidazole8hours.Half Life of Metronidazole8 hours.Side Effects of Metronidazole1.Anorexia.
2.Metallic taste
3.Nausea
4.Vomiting
5.Diarrhoea
6.Headache
7.Looseness of stool.
8.Peripheral neuropathy &CNS effects.
9.Mutagenesis.
10.Radiosensitisation.
11.Transient leucopenia
12.Dry mouth
13.Abdominal distress
14.Dizziness
15.Vertigo
16.Thrombophlebitis at site of injection
17.OtotoxicityContra-indications of Metronidazole1.Hypersensitivity to the drug
2.Blood dyscrasias
3.CNS disorders
Special Precautions while taking Metronidazole1.Renal impairment
2.Hepatic impairment
3.Alcoholic cirrhosis
4.Use cautiously along with other hepatotoxic drugs & In visual field changes
Pregnancy Related InformationUse with caution
First trimester:contra indicatedOld Age Related InformationMay be used.Breast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
Neonates: Contraindicated
Indications for Metronidazole1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Pseudo membranous enterocolitis
5.Anaerobic bacterial infections after surgery, Brain abscess, & Endocarditis
6.Helicobacter pylori infections
7.Ulcerative gingivitis
Interactions for MetronidazoleWarfarin & other coumarin anticoagulants: Potentiates the anticoagulant effect resulting in increased prothrombin time.
Alcohol: A disulfiram-like reaction. Abdominal cramps, nausea, vomiting, headache & flushing.
Disulfiram: Acute psychotic reaction or confusional state.
Phenobarbital & Phenytoin: Increased metabolism of metronidazole resulting in decreased efficacy.
Lithium: Increased lithium levels and toxicity.
Flurouracil: Increased toxicity of flurouracil.
Lab tests: May interfere with chemical analysis for AST,SGOT, ALT, SGPT, LDH, triglycerides and hexokinase glucose. Zero values may occur.Typical Dosage for MetronidazoleAdult
Amoebiasis:400 to 800 mg 8hourly for 5 to 10days depending up on the severity of infection
In severe infections and liver abscess: 1gm as slow I.V. infusion followed by 0.5 gm twice daily till oral therapy is started
Giardiasis:200mg 8hourly for 1week or 2gm/day for 3days or I.V.500mg thrice daily
Trichomonas vaginitis: 400mg 8 hourly for a week or 2gm once daily for a week.
Male partner should be concurrently treated with the drug
Pseudo membranous enterocolitis:800 mg 8hourly
Anaerobic bacterial infections after surgery, Brain abscess, & Endocarditis:400 to 800 mg 8hourly
In severe cases: 15mg/kg I.V. infusion for 1hour followed by 7.5mg/kg 4 times daily till oral therapy is substituted
Helicobacter pylori infections:400mg 8hourly along with amoxicillin/clarithromycin and a proton pump inhibitor
Ulcerative gingivitis:200 to 800mg 8hourly
Children
Amoebiasis: 30 to 50mg/kg/day for 5to10 days.
Giardiasis:10 to 15mg/kg/day thrice daily
Children (below 12years): 7.5mg/kg I.V.Schedule of MetronidazoleHStorage Requirements for MetronidazoleStore in a well closed container in a cool dark place. Keep out of the reach of children.Effects of Missed Dosage of MetronidazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MetronidazoleTreatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal & use of cathartics. For controlling seizures diazepam & phenytoin may be used.Furazolidone
About FurazolidoneA nitro furan derivative, Antibacterial,Antiprotozoal.Mechanism of Action of FurazolidoneFurazolidone is a nitro furan which is employed as a broad spectrum bactericidal agent the actual mechanism of action is not clear. But it is known that it interfere with several bacterial enzyme systems. They have effects on DNA and bring about various changes in bacteria & also have radiomimetic & mutagenic propertiesPharmacokinets of FurazolidoneAbsorption: It is partially absorbed orally
Excretion: It is excreted in urine
Onset of Action for FurazolidoneN/ADuration of Action for FurazolidoneN/AHalf Life of FurazolidoneN/ASide Effects of Furazolidone1. Dizziness
2. Headache
3. Nausea
4. Vomiting
5. Decreased B.P
6. Deafness with tinnitus
7. Urticaria
8. Fever
9. Arthralgia
10. Disulfiram like reactions with alcohol.
Contra-indications of Furazolidone1. Hypersensitivity
2. Along with alcohol
Special Precautions while taking Furazolidone1. Use cautiously in G6PD deficiency
2. Urine colour turns orange which has no clinical significance
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
Neonates : ContraindicatedIndications for Furazolidone1. Bacterial diarrhoea
2. Protozoal diarrhoea
3. Enteritis
4. Giardiasis
5. Trichomoniasis
6. Food poisoning
7. Infections caused by salmonella shigella etc.
8. Bacterial and monilial vaginitis
Interactions for FurazolidoneAlcohol: Disulfiram like reaction-facial flushing,light headedness, weakness, lacrimation.
Anorexiants: Increased pressor response of anorexiants due to MAO inhibition.
Levodopa: Both efficacy and adverse effects of levodopa increased especially hypertensive crisis. Effect lasts for several weeks after stopping furazolidone.
Sympathomimetics (indirect & mixed): Increased pressor sensitivity to these agents due to MAO inhibition.
TCAs: Hypertension, hyperpyrexia, seizures, tachycardia, acute psychosis.
Hypnotics & Sedatives: Dose of hypnotics and sedatives should be reduced.
Hypoglycaemics: Potentiates them.
Food: Hypertensive crisis with tyramine containing foods.
Typical Dosage for FurazolidoneAdults: 100mg 6 hourly 2 to 7 days depending up on the severity of infections
Children: 1.25 mg 6 hourly for 2 to 5 days & up to 10days for Giardiasis
Schedule of FurazolidoneHStorage Requirements for FurazolidoneStore at controlled room temperature at a range of 15 to 30 degree C. in a well closed container and protects from light.Effects of Missed Dosage of FurazolidoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of FurazolidoneTreatment is supportive and symptomatic.Simethicone
About SimethiconeOral anti-foaming agent, Silicones, Antiflatulent.Mechanism of Action of SimethiconeThis anti-gas (anti-flatulence) medication acts in the stomach and intestines to change the surface tension of gas bubbles, enabling smaller bubbles to join together into bigger bubbles. It results elimination of gas more easily by belching or passing flatus.Pharmacokinets of SimethiconeExcretion- Excreted through feces.Onset of Action for SimethiconeN/ADuration of Action for SimethiconeN/AHalf Life of SimethiconeN/ASide Effects of Simethicone1. Bloating
2. Constipation
3. Diarrhea
4. Gas
5. Heartburn
Contra-indications of Simethicone1. Hypersensitivity to the drug
2. Liver disease
3. Kidney disease
4. Serious illness
Special Precautions while taking Simethicone1.Swallow the tablets and capsules with a full glass of water.
2.Chew the chewable tablets thoroughly before swallowing.
3.Shake the drops well before using them.
4.To make administration easier, the drops can be mixed with 30 ml (2 tablespoons) of water or another liquid.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Simethicone1. Abdominal pain which is due to excessive gas in the digestive tract
2. Before gastroscopy or radiography of the bowel
Interactions for SimethiconeN/ATypical Dosage for SimethiconeOral-
Adults and teenagers-
60 -125mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Chewable tablets:
Adults and teenagers-
40 -125 mg four times a day, after meals and at bedtime or 150 mg three times a day, after meals. Not more than 500 mg should be taken in twenty-four hours.
Suspension:
Adults and teenagers-
40 -95 mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Schedule of SimethiconeN/AStorage Requirements for SimethiconeStored at room temperature (15-30?C) away from moisture and heat.Effects of Missed Dosage of SimethiconeTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of SimethiconeGive symptomatic and supportive treatment.Home Delivery for Metronidazole + Furazolidone + Simethicone in Your City
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Metronidazole + Furazolidone + Simethicone is a generic medicine name and there are several brands available for it. Some of the brands for metronidazole + furazolidone + simethicone might be better known than metronidazole + furazolidone + simethicone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have metronidazole + furazolidone + simethicone in stock, you can ask for one of the branded alternatives for metronidazole + furazolidone + simethicone.