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- Pharmacology For Ornidazole + Levofloxacin
Ornidazole + Levofloxacin Pharmacology
Ornidazole + Levofloxacin
About Ornidazole + LevofloxacinN/AMechanism of Action of Ornidazole + LevofloxacinN/APharmacokinets of Ornidazole + LevofloxacinN/AOnset of Action for Ornidazole + LevofloxacinN/ADuration of Action for Ornidazole + LevofloxacinN/AHalf Life of Ornidazole + LevofloxacinN/ASide Effects of Ornidazole + LevofloxacinN/AContra-indications of Ornidazole + LevofloxacinN/ASpecial Precautions while taking Ornidazole + LevofloxacinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ornidazole + LevofloxacinN/AInteractions for Ornidazole + LevofloxacinN/ATypical Dosage for Ornidazole + LevofloxacinN/ASchedule of Ornidazole + LevofloxacinN/AStorage Requirements for Ornidazole + LevofloxacinN/AEffects of Missed Dosage of Ornidazole + LevofloxacinN/AEffects of Overdose of Ornidazole + LevofloxacinN/AOrnidazole
About OrnidazoleA nitro imidazole derivative, Antiprotozoal antibiotic,Antimicrobial.Mechanism of Action of OrnidazoleOrnidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization &strand breakage has been observed.
Pharmacokinets of OrnidazoleAbsorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by conjugation, Excretion: Excreted in urine and small portion is excreted in bile
Onset of Action for OrnidazoleWithin 2 hoursDuration of Action for Ornidazole14hoursHalf Life of Ornidazole12 to 14 hoursSide Effects of Ornidazole1.Abdominal pain
2.Vertigo
3.Nausea
4.Vomiting
5.Fatigue
6.Dry mouth
7.Headache
8.Rash
9.Urticaria
10.Abdominal distress
11.Dizziness
12.VertigoContra-indications of Ornidazole1.Hypersensitivity to the drug or other imidazolesSpecial Precautions while taking Ornidazole1.Vertigo
2.Mental confusion
3.Ataxia
Pregnancy Related InformationUse with caution
First trimester: contra indicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Ornidazole1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Anaerobic bacterial infections
5.Bacterial vaginosis
Interactions for OrnidazoleN/ATypical Dosage for OrnidazoleAmoebiasis:
Adults: 1gm daily in 2 divided doses for 7 to 10 days
Children: 10 to 25mg/kg once daily for 3days
Amoebic dysentery:
Adults: 1.5gm once daily for 3 days
Children: 40mg/kg once daily for 3 days
Trichomoniasis
Adults: 1.5gm single daily dose or 0.5gm 12hourly for 5 days,
Male partner should be concurrently treated.
Children: 25mg/kg as a single dose
Giardiasis:
Adults: 1 to 1.5gm once daily for 2days
Children: 40mg/kg for 2days
Bacterial vaginosis: 1.5gm once or 500mg once daily for 5 to7 days
Schedule of OrnidazoleHStorage Requirements for OrnidazoleStore at cool dry place. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of OrnidazoleTake the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of OrnidazoleTreatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics. Levofloxacin
About LevofloxacinThird generation fluoroquinolone (or quinolone), A broad spectrum antiinfective.Mechanism of Action of LevofloxacinLevofloxacin is a broad spectrum antibacterial agent. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Levofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis. Pharmacokinets of LevofloxacinAbsorption: It is rapidly and completely absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes insignificant metabolism in the liver. Excretion: Drug is excreted mainly through urine.Onset of Action for LevofloxacinN/ADuration of Action for LevofloxacinN/AHalf Life of Levofloxacin6 - 8 hourSide Effects of Levofloxacin1. Nausea
2. Vomiting
3. Diarrhoea
4. Abdominal discomfort
5. Restlessness
6. Dizziness
7. Drowsiness
8. Arthralgia
9. Rash
10. Confusion
11. Insomnia
12. Anorexia
13. Bad taste
14. Headache
15. Photosensitivity.Contra-indications of LevofloxacinHypersensitivity to Levofloxacin and other FluoroquinolonesSpecial Precautions while taking Levofloxacin1.Hepatic impairment
2.Renal impairment
3.Epilepsy
4.Cerebral arteriosclerosis
Caution while driving the vehicle or operating machine or involved in any hazardous activities. Avoid exposure to sun light
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated.Children Related InformationContraindicated
Indications for Levofloxacin1.Sinusitis
2.Bronchitis
3.Pneumonia
4.Urinary tract infection
5.Traveler`s diarrhoea
6.Skin and soft tissue infections
7.UrethritisInteractions for LevofloxacinN/ATypical Dosage for LevofloxacinAdults:
Dose is determined on the basis of severity of the infection, type of infecting organism, age, weight and renal function of the patient.
Sinusitis, Bronchitis, Pneumonia, Skin and soft tissue infections: 500 mg daily for 1 - 2 week
Urinary tract infection: 250 mg / day for 10 days
Traveler`s diarrhoea: 500 mg / day along with Loperamide
Urethritis: 500 mg orally once daily for 7 days
Schedule of LevofloxacinHStorage Requirements for LevofloxacinStore at 25 - 30 degree C in a tightly closed container.Effects of Missed Dosage of LevofloxacinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of LevofloxacinGive supportive measures and symptomatic treatment. Empty the stomach. Maintain appropriate hydration.Home Delivery for Ornidazole + Levofloxacin in Your City
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Ornidazole + Levofloxacin is a generic medicine name and there are several brands available for it. Some of the brands for ornidazole + levofloxacin might be better known than ornidazole + levofloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ornidazole + levofloxacin in stock, you can ask for one of the branded alternatives for ornidazole + levofloxacin.