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- Pharmacology For Ornidazole + Ciprofloxacin
Ornidazole + Ciprofloxacin Pharmacology
Ornidazole + Ciprofloxacin
About Ornidazole + CiprofloxacinN/AMechanism of Action of Ornidazole + CiprofloxacinN/APharmacokinets of Ornidazole + CiprofloxacinN/AOnset of Action for Ornidazole + CiprofloxacinN/ADuration of Action for Ornidazole + CiprofloxacinN/AHalf Life of Ornidazole + CiprofloxacinN/ASide Effects of Ornidazole + CiprofloxacinN/AContra-indications of Ornidazole + CiprofloxacinN/ASpecial Precautions while taking Ornidazole + CiprofloxacinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ornidazole + CiprofloxacinN/AInteractions for Ornidazole + CiprofloxacinN/ATypical Dosage for Ornidazole + CiprofloxacinN/ASchedule of Ornidazole + CiprofloxacinN/AStorage Requirements for Ornidazole + CiprofloxacinN/AEffects of Missed Dosage of Ornidazole + CiprofloxacinN/AEffects of Overdose of Ornidazole + CiprofloxacinN/AOrnidazole
About OrnidazoleA nitro imidazole derivative, Antiprotozoal antibiotic,Antimicrobial.Mechanism of Action of OrnidazoleOrnidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization &strand breakage has been observed.
Pharmacokinets of OrnidazoleAbsorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by conjugation, Excretion: Excreted in urine and small portion is excreted in bile
Onset of Action for OrnidazoleWithin 2 hoursDuration of Action for Ornidazole14hoursHalf Life of Ornidazole12 to 14 hoursSide Effects of Ornidazole1.Abdominal pain
2.Vertigo
3.Nausea
4.Vomiting
5.Fatigue
6.Dry mouth
7.Headache
8.Rash
9.Urticaria
10.Abdominal distress
11.Dizziness
12.VertigoContra-indications of Ornidazole1.Hypersensitivity to the drug or other imidazolesSpecial Precautions while taking Ornidazole1.Vertigo
2.Mental confusion
3.Ataxia
Pregnancy Related InformationUse with caution
First trimester: contra indicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Ornidazole1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Anaerobic bacterial infections
5.Bacterial vaginosis
Interactions for OrnidazoleN/ATypical Dosage for OrnidazoleAmoebiasis:
Adults: 1gm daily in 2 divided doses for 7 to 10 days
Children: 10 to 25mg/kg once daily for 3days
Amoebic dysentery:
Adults: 1.5gm once daily for 3 days
Children: 40mg/kg once daily for 3 days
Trichomoniasis
Adults: 1.5gm single daily dose or 0.5gm 12hourly for 5 days,
Male partner should be concurrently treated.
Children: 25mg/kg as a single dose
Giardiasis:
Adults: 1 to 1.5gm once daily for 2days
Children: 40mg/kg for 2days
Bacterial vaginosis: 1.5gm once or 500mg once daily for 5 to7 days
Schedule of OrnidazoleHStorage Requirements for OrnidazoleStore at cool dry place. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of OrnidazoleTake the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of OrnidazoleTreatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics. Ciprofloxacin
About CiprofloxacinIt is a broad spectrum fluoroquinolone with activity against Pseudomonas aeruginosa.
EYE DROPS: It is a fluroquinolone antibacterial having broad spectrum of activity.Mechanism of Action of CiprofloxacinCiprofloxacin is a bacteriostatic at low concentration and bactericidal at high concentration. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Ciprofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.Pharmacokinets of CiprofloxacinAbsorption: They are adequately absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes hepatic metabolism. Excretion: Drug is excreted mainly through urine.
Onset of Action for CiprofloxacinWithin 1hr.
Duration of Action for Ciprofloxacin8-12 hours.
Half Life of Ciprofloxacin3 - 5 hourSide Effects of Ciprofloxacin1.Nausea
2.Vomiting
3.Diarrhoea
4.Abdominal discomfort
5.Restlessness
6.Dizziness
7.Drowsiness
8.Arthralgia
9.Rash
10.Confusion
11.Insomnia
12.Anorexia
13.Bad taste
14.Headache
15.Photosensitivity
Contra-indications of CiprofloxacinHypersensitivity to Ciprofloxacin and other FluoroquinolonesSpecial Precautions while taking Ciprofloxacin1.Hepatic impairment
2.Renal impairment
3.Epilepsy
4.Dehydration
5.Caution while driving the vehicle or operating machine or involved in any hazardous activities.
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: contraindicatedIndications for Ciprofloxacin1.Urinary tract infection
2.Respiratory tract infection
3.Bone and joint infections,
4.Infectious diarrhoea
5.Gonorrhoea
6.ENT infections
7.Skin and soft tissue infections
8.Typhoid fever
9.Intra-abdominal infections
10.Prostatitis
11. Sinusitis
12.Chancroid
13.Gynaecological infections
14.TularemiaInteractions for CiprofloxacinAntacids (aluminium/magnesium hydroxide), Iron salts, Zinc salts.: Absorption of ciprofloxacin is decreased.
Antineoplastic drugs: Decrease serum levels of ciprofloxacin.
Caffeine: Enhanced efficacy of caffeine.
Oral anti-coagulants: Enhanced efficacy of anti-coagulants.
Cyclosporine: Nephrotoxicity increased by ciprofloxacin.
Theophylline: Increased plasma levels of theophylline resulting in toxicity.
NSAIDs: CNS excitation may occur.
Rifampicin: Decreases serum concenteration of ciprofloxacin.
Chloramphenicol: Antagonises effects of ciprofloxacin.Typical Dosage for CiprofloxacinAdults:
Dose is determined on the basis of severity of the infection, type of infecting organism, age, weight and renal function of the patient.
UTI: 0.5 - 1 g / day in 2 divided doses.
Respiratory tract infection, Bone and joint infections, Infectious diarrhoea, ENT infections, .Skin and soft tissue infections, Enteric fever: 1 - 1.5 g / day in 2 divided doses
Typhoid fever, Intra-abdominal infections, Gynaecological infection: 1 g / day in 2 divided doses
Uncomplicated gonorrhea: 250 mg / day
Schedule of CiprofloxacinHStorage Requirements for CiprofloxacinStore at 15 - 30 degree C in a tightly closed container.Effects of Missed Dosage of CiprofloxacinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of CiprofloxacinGive supportive measures and symptomatic treatment. Induce emesis or gastric lavage has to be done. Dialysis can be done if necessary.Home Delivery for Ornidazole + Ciprofloxacin in Your City
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Ornidazole + Ciprofloxacin is a generic medicine name and there are several brands available for it. Some of the brands for ornidazole + ciprofloxacin might be better known than ornidazole + ciprofloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ornidazole + ciprofloxacin in stock, you can ask for one of the branded alternatives for ornidazole + ciprofloxacin.