Pentazocine Pharmacology

Pentazocine

About Pentazocine
Benzomorphan derivative, Opioid Analgesic(centrally acting analgesic).
Mechanism of Action of Pentazocine
It is morphine like Opioid analgesic. Its analgesic action is due to the agonistic action at kappa Opioid receptors. At mu receptors it has weak agonistic and partial antagonistic action. It produces more dysphoria than euphoria because of the activation at supraspinal kappa receptors. Its psycho mimetic activity is due to the action at sigma Opioid receptors. On respiratory depression it has a ceiling effect i.e. by increasing the dose there is no increase of respiratory depression. Symptoms of withdrawal are less in this drug than morphine.
Pharmacokinets of Pentazocine
Absorption. Orally well absorbed but its bioavailability is low due to first pass metabolism. In patients with hepatic dysfunction can absorb 60-70% of the drug.It is rapidly absorbed after intra venous, intramuscular and subcutaneous administration.
Distribution:-Widely distributed in the body.
Metabolism -It undergoes metabolism by oxidation and glucoronidation in liver.
Excretion-It is excreted via urine and a small amount through faeces.
Onset of Action for Pentazocine
Oral. 15-30min
Intravenous. 2 - 3min
Intramuscular and Subcutaneous. 10 - 20min
Duration of Action for Pentazocine
2 - 3 hrs
Half Life of Pentazocine
2 - 3 hrs
Side Effects of Pentazocine
1. Sedation
2. Light headedness
3. Euphoria
4. Psychomimetic effect
5. Shock
6. Hypertension
7. Hypotension
8. Constipation
9. Nausea
10. Vomiting
11. Urine retention
12. Respiratory depression
13. Dyspnea
14. Apnea
15. Sclerosis of injection site
16. Pruritis
17. Psychological dependence
Contra-indications of Pentazocine
1. Hypersensitivity to the drug
2. Myocardial infarction
3. Hypertension
4. Pregnancy
6. Increased intracranial pressure
7. Respiratory failure
8. Narcotic dependence
Special Precautions while taking Pentazocine
1. Labour
2. Elderly patients
3. Patients with head injury
4. Respiratory depression
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
N/A
Children Related Information
Use with caution
Indications for Pentazocine
1. Pain in -Trauma, Surgery, Burns, Labour, Cancer
2. Pre- anaesthetic medication
Interactions for Pentazocine
Alcohol : Increased CNS depressant effects.
Barbiturate anaesthetics : May increase respiratory & CNS depression effects of pentazocine.
Typical Dosage for Pentazocine
Oral :
Adults -50 to 100 mg every 3-4 times.
Intravenous,Intramuscular and Subcutaneous - 30 to 60mg every 3-4 times.
Labour patient-30mg i.v or 20 mg i.m in 2 to 3 hour interval.
Rectal :50mg suppository 4 times daily.
Oral:
Children: 25mg every 3-4 times.
Schedule of Pentazocine
H
Storage Requirements for Pentazocine
Store at room temperature.
Effects of Missed Dosage of Pentazocine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Pentazocine
Take all supportive measures. Give mechanical ventilation. If respiratory depression occurs give an antagonistic parenterally e.g.Naloxone.

Home Delivery for Pentazocine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including pentazocine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for pentazocine and other medicines and health products. Home delivery services for pentazocine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take pentazocine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for pentazocine before they complete the sale. You can get this information while placing the order for pentazocine with the pharmacy.

Pentazocine is a generic medicine name and there are several brands available for it. Some of the brands for pentazocine might be better known than pentazocine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have pentazocine in stock, you can ask for one of the branded alternatives for pentazocine.