Racecadotril Pharmacology

Racecadotril

About Racecadotril
A peripherally acting Enkephalinase inhibitor, Antidiarrheal.

Mechanism of Action of Racecadotril
Racecadotril is a dipeptide. It is an Enkephalinase inhibitor which prevents the degradation of Enkephalins. Enkephalins are endogenous opioid which act on delta opioid receptor and reduces the cyclic AMP level and produces antidiarrhoeal effect. Thus the increased concentration of Enkephalins reduces the hyper secretions of water and electrolyte in to the intestinal lumen. Racecadotril reduces the incidence of diarrhoea and diarrhoea associated symptoms.
Pharmacokinets of Racecadotril
Absorption: Racecadotril is rapidly absorbed after oral administration.
Metabolism: It is rapidly metabolised by gastric enzyme lipase to active thiorphan metabolite.
Onset of Action for Racecadotril
30 minutes
Duration of Action for Racecadotril
N/A
Half Life of Racecadotril
3 hours
Side Effects of Racecadotril
1. Nausea
2. Vomiting
3. Thirst
4. Vertigo
5. Headache
6. Constipation
Contra-indications of Racecadotril
1. Hypersensitivity to Racecadotril
Special Precautions while taking Racecadotril
1. Renal insufficiency
2. Functional intestinal disorders
3. Dysenteric symptoms with bloody stools
4. Dehydration
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Racecadotril
1. Acute symptomatic diarrhoea
Interactions for Racecadotril
No clinically significant interactions involving interference with drug metabolism have been reported with Racecadotril.
Typical Dosage for Racecadotril
Adult: 300 mg/ day in 3 divided doses to be taken before meals.
Children: 4.5 mg / kg /day in 3 divided doses.
Schedule of Racecadotril
N/A
Storage Requirements for Racecadotril
Store below 25 degree C. Protect from light and moisture.
Effects of Missed Dosage of Racecadotril
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Racecadotril
Give supportive measures and symptomatic treatment.

Home Delivery for Racecadotril in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including racecadotril.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for racecadotril and other medicines and health products. Home delivery services for racecadotril may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take racecadotril only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for racecadotril before they complete the sale. You can get this information while placing the order for racecadotril with the pharmacy.

Racecadotril is a generic medicine name and there are several brands available for it. Some of the brands for racecadotril might be better known than racecadotril itself. If the pharmacy that's willing to deliver medicines to your home doesn't have racecadotril in stock, you can ask for one of the branded alternatives for racecadotril.