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- Pharmacology For Ibuprofen + Paracetamol + Magnesium Trisilicate
Ibuprofen + Paracetamol + Magnesium Trisilicate Pharmacology
Ibuprofen + Paracetamol + Magnesium Trisilicate
About Ibuprofen + Paracetamol + Magnesium TrisilicateN/AMechanism of Action of Ibuprofen + Paracetamol + Magnesium TrisilicateN/APharmacokinets of Ibuprofen + Paracetamol + Magnesium TrisilicateN/AOnset of Action for Ibuprofen + Paracetamol + Magnesium TrisilicateN/ADuration of Action for Ibuprofen + Paracetamol + Magnesium TrisilicateN/AHalf Life of Ibuprofen + Paracetamol + Magnesium TrisilicateN/ASide Effects of Ibuprofen + Paracetamol + Magnesium TrisilicateN/AContra-indications of Ibuprofen + Paracetamol + Magnesium TrisilicateN/ASpecial Precautions while taking Ibuprofen + Paracetamol + Magnesium TrisilicateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ibuprofen + Paracetamol + Magnesium TrisilicateN/AInteractions for Ibuprofen + Paracetamol + Magnesium TrisilicateN/ATypical Dosage for Ibuprofen + Paracetamol + Magnesium TrisilicateN/ASchedule of Ibuprofen + Paracetamol + Magnesium TrisilicateN/AStorage Requirements for Ibuprofen + Paracetamol + Magnesium TrisilicateN/AEffects of Missed Dosage of Ibuprofen + Paracetamol + Magnesium TrisilicateN/AEffects of Overdose of Ibuprofen + Paracetamol + Magnesium TrisilicateN/AIbuprofen
About IbuprofenNSAID, a propionic acid derivative, Analgesic and anti-inflammatory.Mechanism of Action of IbuprofenIbuprofen has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other algesics. Ibuprofen inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions. It also inhibits platelet aggregation and prolongs bleeding time.Pharmacokinets of IbuprofenAbsorption: Ibuprofen is rapidly absorbed after oral administration. Distribution: It is distributed in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Ibuprofen and its metabolites are excreted mainly in the urine and some amount in bile.Onset of Action for Ibuprofen? hoursDuration of Action for Ibuprofen4-6 hours.Half Life of Ibuprofen2 hoursSide Effects of Ibuprofen1.Nausea
2.Vomiting
3.Diarrhoea
4.Gastrointestinal bleeding
5.Abdominal distress
6.Constipation
7.Peptic ulcer
8.Dyspepsia
9.Headache
10.Drowsiness
11.Blurring of vision
12.Tinnitus
13.Depression
14.Thrombocytopenia
15.Rash
16.Pruritis
Contra-indications of Ibuprofen1.Hypersensitivity to Ibuprofen and other NSAIDs
2.Peptic ulcer
Special Precautions while taking Ibuprofen1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Gastrointestinal diseases
5.Pre existing asthma
6.Bleeding disorders
7.Phenylketonuria
8.Oedema
9.Heart failure
10.Myocardial infarction
11.Stroke
Pregnancy Related InformationUse with caution
PREGNANCY in third trimester: contraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
CHILDREN below 6 months: contraindicatedIndications for Ibuprofen1.Rheumatoid arthritis
2.Ankylosing spondylitis
3.Acute gout
4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
5.Osteoarthritis
6.For the relief of fever, pain and inflammation in dental, minor surgery and orthopedic
7.Dysmenorrhoea
8.Juvenile arthritis
9.Migraine
10.Patent ductus arteriosus(IV)
Interactions for IbuprofenN/ATypical Dosage for IbuprofenAdult: 1.2 g / day in3 divided doses
Arthritis, gout and dental pain: 300 - 800 mg 3 times daily dose can be increased if needed.
Maximum dose: 3200 mg / day
Pain, Dysmenorrhoea: 1600 - 2400 mg / day in 4 - 6 divided doses
Fever: 600 mg / day in 3 divided doses.
Maximum dose: 1200 mg / day
For migraine: 400 -800 mg 3 times daily
Children: 15- 20 mg / kg body weight / day in 3 - 4 divided doses
Maximum dose: 40 mg / kg body weight / day
Schedule of IbuprofenHStorage Requirements for IbuprofenStore Ibuprofen at 15-30 degree C in a tightly closed light resistant container.Effects of Missed Dosage of IbuprofenTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of IbuprofenGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Excretion of the drug can be enhanced by administration of alkaline diuretics.Paracetamol
About ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Magnesium Trisilicate
About Magnesium TrisilicateMineral, Magnesium compound, Antacid.Mechanism of Action of Magnesium TrisilicateN/APharmacokinets of Magnesium TrisilicateN/AOnset of Action for Magnesium TrisilicateN/ADuration of Action for Magnesium TrisilicateN/AHalf Life of Magnesium TrisilicateN/ASide Effects of Magnesium TrisilicateN/AContra-indications of Magnesium TrisilicateN/ASpecial Precautions while taking Magnesium TrisilicateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Magnesium TrisilicateN/AInteractions for Magnesium TrisilicateN/ATypical Dosage for Magnesium TrisilicateN/ASchedule of Magnesium TrisilicateN/AStorage Requirements for Magnesium TrisilicateN/AEffects of Missed Dosage of Magnesium TrisilicateN/AEffects of Overdose of Magnesium TrisilicateN/AHome Delivery for Ibuprofen + Paracetamol + Magnesium Trisilicate in Your City
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