Mosapride + Dimethicone Pharmacology

Mosapride + Dimethicone

About Mosapride + Dimethicone
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Mechanism of Action of Mosapride + Dimethicone
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Pharmacokinets of Mosapride + Dimethicone
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Onset of Action for Mosapride + Dimethicone
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Duration of Action for Mosapride + Dimethicone
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Half Life of Mosapride + Dimethicone
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Side Effects of Mosapride + Dimethicone
N/A
Contra-indications of Mosapride + Dimethicone
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Special Precautions while taking Mosapride + Dimethicone
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Mosapride + Dimethicone
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Interactions for Mosapride + Dimethicone
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Typical Dosage for Mosapride + Dimethicone
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Schedule of Mosapride + Dimethicone
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Storage Requirements for Mosapride + Dimethicone
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Effects of Missed Dosage of Mosapride + Dimethicone
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Effects of Overdose of Mosapride + Dimethicone
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Mosapride

About Mosapride
A selective 5HT4 agonist, A gastroprokinetic agent.
Mechanism of Action of Mosapride
Mosapride is a Prokinetic drug. It is a 5 HT4 receptor agonist as well as 5HT3 receptor antagonist in the myenteric plexus. Enterochromaffin cells in the gastrointestinal mucosa produces and releases serotonin in response to stimuli (chemical or mechanical stimulation).Serotonin will enhances peristaltic movement by stimulating sensory neurons in the myenteric plexus. Stimulation of 5HT4 receptors will increase the release of Acetylcholine. The metabolite of Mosapride produces 5HT3 receptor antagonism and suppresses the inhibitory transmission in myenteric plexus. These all results in increased oesophageal peristaltic activity, lower oesophageal sphincter tone and enhances intestinal propulsive activity.
Pharmacokinets of Mosapride
Absorption:It is absorbed after oral administration.Excretion: It is excreted mainly urine and faeces.

Onset of Action for Mosapride
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Duration of Action for Mosapride
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Half Life of Mosapride
2 - 3 hours
Side Effects of Mosapride
1.Diarrhoea
2.Abdominal cramps
3.Headache
4.Dry mouth
5.Nausea
Contra-indications of Mosapride
1.Hypersensitivity to Mosapride
Special Precautions while taking Mosapride
1.Hepatic impairment
2.Renal impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
NEONATES: contraindicated
Indications for Mosapride
1.Gastroesophageal reflux diseases
2.Functional dyspepsia
3.Diabetic gastropathy
4.Disorders associated with decreased gastric motility
5.Nausea
Interactions for Mosapride
Mosapride`s major degradation system is the cytochrome P450 (3A4) system. However, electrophysiological studies show that coadministration of drugs that inhibit the CYP 3A4 enzymes (erythromycin, ketoconazole, fluconazole, etc.) have no effect on mosapride indicating that a satisfactory safety margin exists in relation to rhythm abnormalities, unlike that which occurs with cisapride.
Typical Dosage for Mosapride
Adult:
Oral:2.5 - 10 mg every 6 - 8 hours in a day with meals
Children:not recommended
Schedule of Mosapride
N/A
Storage Requirements for Mosapride
Store at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Mosapride
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Mosapride
Give supportive measures and symptomatic treatment.

Dimethicone

About Dimethicone
Oral anti -foaming agent, a flexible silicone polymer, Antiflatulent ,Antibloating agent.
Mechanism of Action of Dimethicone
Activated Dimethicone relieves flatulence by dispensing and preventing formation of mucus surrounding gas pockets in the gastro-intestinal tract. It lowers the surface tension of the gas bubbles and bringing together all the small bubbles of gas (coalesce) to form a large bubble, which is then expelled. Thus the gas is freed by belching or passing flatus.
Antiflatulents are added to an antacid gum coating to be effective antigas materials and eliminate trapped gas. The most common antigas material is Dimethicone and when mixed with silicone dioxide becomes Simethicone. Simethicone is also referred to as activated Dimethicone. Simethicone is the most common antigas material and may be the only drug approved antiflatulent.
As the antacid chewing tablet is chewed, the active antacid and antiflatulent in the gum coating is released into the saliva and ingested to give relief from gastrointestinal disturbances in the gastro-intestinal tract.
Besides its antigas effect, Simethicone used in a gum coating can also improve the smoothness of the coating. Activated Dimethicone helps to relieve pain and bloating caused by trapped wind.
Pharmacokinets of Dimethicone
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Onset of Action for Dimethicone
N/A
Duration of Action for Dimethicone
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Half Life of Dimethicone
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Side Effects of Dimethicone
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Contra-indications of Dimethicone
Hypersensitivity to Dimethicone activated
Special Precautions while taking Dimethicone
Kidney failure
Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Dimethicone
1. Flatulent dyspepsia
2. Postoperative distension
3. Gastric Distention
4. Functional digestive disorders
5. Stomach pain
6. Burning
7. Nausea and excess gas (dyspepsia)
Interactions for Dimethicone
N/A
Typical Dosage for Dimethicone
125 - 166 mg taken half an hour before food.
Dimethicone in a coated chewing gum: 5 mg - 200 mg per piece of coated gum.
With an antacid: 20 mg -50 mg of Dimethicone
Schedule of Dimethicone
N/A
Storage Requirements for Dimethicone
Stored at room temperature (15-30?C) away from moisture and heat.
Effects of Missed Dosage of Dimethicone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dimethicone
Give symptomatic and supportive treatment.

Home Delivery for Mosapride + Dimethicone in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mosapride + dimethicone and other medicines and health products. Home delivery services for mosapride + dimethicone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take mosapride + dimethicone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mosapride + dimethicone before they complete the sale. You can get this information while placing the order for mosapride + dimethicone with the pharmacy.

Mosapride + Dimethicone is a generic medicine name and there are several brands available for it. Some of the brands for mosapride + dimethicone might be better known than mosapride + dimethicone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mosapride + dimethicone in stock, you can ask for one of the branded alternatives for mosapride + dimethicone.