Sucralfate + Oxethazaine Pharmacology

Sucralfate + Oxethazaine

About Sucralfate + Oxethazaine
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Mechanism of Action of Sucralfate + Oxethazaine
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Pharmacokinets of Sucralfate + Oxethazaine
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Onset of Action for Sucralfate + Oxethazaine
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Duration of Action for Sucralfate + Oxethazaine
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Half Life of Sucralfate + Oxethazaine
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Side Effects of Sucralfate + Oxethazaine
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Contra-indications of Sucralfate + Oxethazaine
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Special Precautions while taking Sucralfate + Oxethazaine
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Sucralfate + Oxethazaine
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Interactions for Sucralfate + Oxethazaine
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Typical Dosage for Sucralfate + Oxethazaine
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Schedule of Sucralfate + Oxethazaine
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Storage Requirements for Sucralfate + Oxethazaine
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Effects of Missed Dosage of Sucralfate + Oxethazaine
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Effects of Overdose of Sucralfate + Oxethazaine
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Sucralfate

About Sucralfate
Pepsin inhibitor, Anti-secretory, Gastrointestinal Agent, antiulcer.
Mechanism of Action of Sucralfate
Sucralfate is a complex of sucrose, sulfate and aluminium hydroxide. In the stomach (pH<4) Sucralfate undergoes polymerization and form viscous sticky polymers that adhere to the surface of ulcers and coat the ulcer.
It also protects the ulcer surface from further injury by inhibiting the enzyme pepsin which hydrolysis mucosal proteins. Sucralfate increases the production of Prostaglandins and protect the lining of the stomach. It also binds to the epithelial growth factor and Fibroblast factor and repair the mechanism of stomach lining.

Pharmacokinets of Sucralfate
Absorption: Sucralfate is poorly absorbed after oral administration.
Distribution: It is mainly distributed to the ulcer site and the absorbed drug is distributed to body tissues.
Excretion: It is excreted mainly in the faeces and the absorbed drug is excreted in the urine.
Onset of Action for Sucralfate
With in minutes
Duration of Action for Sucralfate
6 hours
Half Life of Sucralfate
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Side Effects of Sucralfate
1. Constipation
2. Diarrhoea
3. Nausea
4. Headache
5. Vertigo
6. Dizziness
7. Abdominal discomfort
8. Rash
9. Urticaria
Contra-indications of Sucralfate
1. Hypersensitivity to Sucralfate
Special Precautions while taking Sucralfate
1. Chronic renal failure
2. Hypophosphataemia
3. Monitor gastric malignancy
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
NEONATES: Contraindicated

Indications for Sucralfate
1. Duodenal ulcer
2. Gastric ulcer
3. Stress ulcer
4. Chronic gastritis
Interactions for Sucralfate
Antibacterials (ciprofloxacin, norfloxacin, ofloxacin and tetracycline), Antiepileptics (phenytoin), Antifungals (ketoconazole), Cardiac glycosides (digoxin), Thyroxine: Sucralfate may reduce the absorption of these drugs.
Anticoagulants: Reduced efficacy of warfarin.
Antacids (aluminium containing) :Total body burden of aluminium may be increased.
Cimetidine, Ranitidine and Theophylline: Reduced bioavailability of these drugs.
Quinidine: Serum quinidine levels may be reduced.
Typical Dosage for Sucralfate
Adult:
Oral dose: 4 g / day in 2 - 4 divided doses drug to be taken 1 hour before meals and at bed time.
Suspension: 10 ml to be taken 4 times daily.
Children: not recommended

Schedule of Sucralfate
H
Storage Requirements for Sucralfate
Store at 15 - 30 degree C in a tightly closed container. Protect from light.
Effects of Missed Dosage of Sucralfate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Sucralfate
Give supportive measures and symptomatic treatment.

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Home Delivery for Sucralfate + Oxethazaine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including sucralfate + oxethazaine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for sucralfate + oxethazaine and other medicines and health products. Home delivery services for sucralfate + oxethazaine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take sucralfate + oxethazaine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for sucralfate + oxethazaine before they complete the sale. You can get this information while placing the order for sucralfate + oxethazaine with the pharmacy.

Sucralfate + Oxethazaine is a generic medicine name and there are several brands available for it. Some of the brands for sucralfate + oxethazaine might be better known than sucralfate + oxethazaine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have sucralfate + oxethazaine in stock, you can ask for one of the branded alternatives for sucralfate + oxethazaine.