Domperidone + Magaldrate + Simethicone Pharmacology

Domperidone + Magaldrate + Simethicone

About Domperidone + Magaldrate + Simethicone
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Mechanism of Action of Domperidone + Magaldrate + Simethicone
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Pharmacokinets of Domperidone + Magaldrate + Simethicone
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Onset of Action for Domperidone + Magaldrate + Simethicone
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Duration of Action for Domperidone + Magaldrate + Simethicone
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Half Life of Domperidone + Magaldrate + Simethicone
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Side Effects of Domperidone + Magaldrate + Simethicone
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Contra-indications of Domperidone + Magaldrate + Simethicone
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Special Precautions while taking Domperidone + Magaldrate + Simethicone
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Domperidone + Magaldrate + Simethicone
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Interactions for Domperidone + Magaldrate + Simethicone
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Typical Dosage for Domperidone + Magaldrate + Simethicone
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Schedule of Domperidone + Magaldrate + Simethicone
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Storage Requirements for Domperidone + Magaldrate + Simethicone
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Effects of Missed Dosage of Domperidone + Magaldrate + Simethicone
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Effects of Overdose of Domperidone + Magaldrate + Simethicone
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Domperidone

About Domperidone
Antidopaminergic, Motility stimulant,Piperidine derivative, Antiemetic, anti-vertigo.
Mechanism of Action of Domperidone
Domperidone is a potent dopamine receptor antagonist. It acts centrally and blocks the Dopamine receptor in the Chemoreceptor trigger zone and produces Antiemetic effect.
Domperidone acts peripherally in the gastrointestinal system and increases oesophageal peristalsis, oesophageal sphincter pressure and gastric motility. These all facilitates gastric emptying. Domperidone is used in migraine to relieve nausea and vomiting.
Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
Pharmacokinets of Domperidone
Absorption: Domperidone is rapidly absorbed after oral administration. Since it undergoes first pass metabolism oral bioavailability is only 15 %. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Domperidone undergoes metabolism in the liver. Excretion: It is excreted mainly in the faeces and also in the urine.
Onset of Action for Domperidone
30 - 60 minutes
Duration of Action for Domperidone
6 - 8 hours
Half Life of Domperidone
7.5 hours
Side Effects of Domperidone
1.Diarrhoea
2.Dry mouth
3.Galactorrhoea
4.Gynaecomastia
5.Skin rash
6.Abdominal discomfort
7.Dystonic reactions
Contra-indications of Domperidone
1.Hypersensitivity to Domperidone
2.Prolactin releasing pituitary tumour(prolactinoma)
3.Gastrointestinal obstruction
Special Precautions while taking Domperidone
1.Hepatic impairment
2.Renal impairment
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Domperidone
1.Nausea and vomiting associated with gastrointestinal disorder and migraine.
2.Delayed gastric emptying of functional origin
3.As an Antiemetic in patient receiving cytotoxic drugs
4.Preanaesthetic medication

Interactions for Domperidone
Digoxin: Oral dose of digoxin needs to be reduced.
Aspirin, Paracetamol & Oral Diazepam: Increases absorption of these agents.
Anticholinergic agents: Antagonize the effects of domperidone.
Phenothiazines: CNS depression enhanced by domperidone.
Antimuscarinic agents and opioids: Antagonize GI effects of domperidone.
Suxamethonium: Neuromuscular blockade enhanced by domperidone.
Typical Dosage for Domperidone
Adults: 30 - 40 mg / day in 3 - 4 divided doses 30 minutes before meals and at bed time if required. After 2 weeks dose can be increased to 60 - 80 mg / day if needed.
Migraine: 20 mg by mouth may be taken up to every 4 hours with Paracetamol, as required up to a maximum of 4 doses in 24 hours.
Children: 300 mcg / kg body weight 3 - 4 times daily 30 minutes before meals and at bed time if required
Schedule of Domperidone
H
Storage Requirements for Domperidone
Store at room temperature (15 - 30 degree C). Protect from direct sun light and moisture
Effects of Missed Dosage of Domperidone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Domperidone
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage and absorption of the drug can be reduced by administration of activated charcoal. To control Extrapyramidal reactions give antiparkinsonian or anticholinergic agents.

Magaldrate

About Magaldrate
Chemical complex of aluminum and magnesium hydroxides, Antacid.
Mechanism of Action of Magaldrate
This neutralizes the gastric acid and increases the gastric pH. This reduces the direct acid irritant effect. It also enhances mucosal barrier integrity and improves gastroesophageal sphincter tone.
Pharmacokinets of Magaldrate
Absorption- Moderately absorbed after oral administration. Distribution- It is distributed through locally. Excretion- Excreted through feces and a small amount through breast milk.
Onset of Action for Magaldrate
20minutes
Duration of Action for Magaldrate
20 to 180 minutes
Half Life of Magaldrate
N/A
Side Effects of Magaldrate
1. Constipation
2. Diarrhea
3. Increased urine pH
4. Decreased serum potassium levels
5. Increased serum calcium levels
Contra-indications of Magaldrate
1. Hypersensitivity to the drug or any ingredients of it
2. Renal impairment or diseases
3. Hypophosphatemia
Special Precautions while taking Magaldrate
1.Take this medicine between meals and at bedtime.
2.Shake the oral liquid well before each use.
3.Chew the chewable tablet before swallowing.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Magaldrate
1. Peptic ulcer
2. Gastritis
3. Reflux oesophagitis
4. Gastric hyperacidity
Interactions for Magaldrate
N/A
Typical Dosage for Magaldrate
Oral-
Adults-
Suspension: 5 to 10 ml between meals and at bedtime with water
Schedule of Magaldrate
N/A
Storage Requirements for Magaldrate
Store at room temperature (15 - 25 degree C). Keep out of reach of children.
Effects of Missed Dosage of Magaldrate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Magaldrate
Give symptomatic and supportive treatment.

Simethicone

About Simethicone
Oral anti-foaming agent, Silicones, Antiflatulent.
Mechanism of Action of Simethicone
This anti-gas (anti-flatulence) medication acts in the stomach and intestines to change the surface tension of gas bubbles, enabling smaller bubbles to join together into bigger bubbles. It results elimination of gas more easily by belching or passing flatus.
Pharmacokinets of Simethicone
Excretion- Excreted through feces.
Onset of Action for Simethicone
N/A
Duration of Action for Simethicone
N/A
Half Life of Simethicone
N/A
Side Effects of Simethicone
1. Bloating
2. Constipation
3. Diarrhea
4. Gas
5. Heartburn
Contra-indications of Simethicone
1. Hypersensitivity to the drug
2. Liver disease
3. Kidney disease
4. Serious illness
Special Precautions while taking Simethicone
1.Swallow the tablets and capsules with a full glass of water.
2.Chew the chewable tablets thoroughly before swallowing.
3.Shake the drops well before using them.
4.To make administration easier, the drops can be mixed with 30 ml (2 tablespoons) of water or another liquid.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Simethicone
1. Abdominal pain which is due to excessive gas in the digestive tract
2. Before gastroscopy or radiography of the bowel
Interactions for Simethicone
N/A
Typical Dosage for Simethicone
Oral-
Adults and teenagers-
60 -125mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Chewable tablets:
Adults and teenagers-
40 -125 mg four times a day, after meals and at bedtime or 150 mg three times a day, after meals. Not more than 500 mg should be taken in twenty-four hours.
Suspension:
Adults and teenagers-
40 -95 mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Schedule of Simethicone
N/A
Storage Requirements for Simethicone
Stored at room temperature (15-30?C) away from moisture and heat.
Effects of Missed Dosage of Simethicone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Simethicone
Give symptomatic and supportive treatment.

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