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- Pharmacology For Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide
Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide Pharmacology
Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide
About Aluminium Hydroxide + Calcium + Dimethicone + Magnesium HydroxideN/AMechanism of Action of Aluminium Hydroxide + Calcium + Dimethicone + Magnesium HydroxideN/APharmacokinets of Aluminium Hydroxide + Calcium + Dimethicone + Magnesium HydroxideN/AOnset of Action for Aluminium Hydroxide + Calcium + Dimethicone + Magnesium HydroxideN/ADuration of Action for Aluminium Hydroxide + Calcium + Dimethicone + Magnesium HydroxideN/AHalf Life of Aluminium Hydroxide + Calcium + Dimethicone + Magnesium HydroxideN/ASide Effects of Aluminium Hydroxide + Calcium + Dimethicone + Magnesium HydroxideN/AContra-indications of Aluminium Hydroxide + Calcium + Dimethicone + Magnesium HydroxideN/ASpecial Precautions while taking Aluminium Hydroxide + Calcium + Dimethicone + Magnesium HydroxideN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Aluminium Hydroxide + Calcium + Dimethicone + Magnesium HydroxideDimethicone is added to an antacid as an antifoaming agent to relieve flatulence. It is also useful for the relief of hiccup.
1.Hyperacidity
2.Peptic ulcer
Interactions for Aluminium Hydroxide + Calcium + Dimethicone + Magnesium HydroxideN/ATypical Dosage for Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide1 - 2 tablets to be chewed 30 - 60 minutes after meals 3 - 4 times daily.Schedule of Aluminium Hydroxide + Calcium + Dimethicone + Magnesium HydroxideN/AStorage Requirements for Aluminium Hydroxide + Calcium + Dimethicone + Magnesium HydroxideN/AEffects of Missed Dosage of Aluminium Hydroxide + Calcium + Dimethicone + Magnesium HydroxideN/AEffects of Overdose of Aluminium Hydroxide + Calcium + Dimethicone + Magnesium HydroxideN/AAluminium Hydroxide
About Aluminium HydroxideAntacid,Antidote,Protectant( Topical), In hyperacidity; hyperphosphatemia.Mechanism of Action of Aluminium HydroxideIt neutralizes and reduces stomach acid relieving heartburn (acid reflux, GERD) and indigestion. This results increased pH and reduce the pepsin activity. It also binds to the phosphate in the gut and form a nonsoluble nonabsorbable aluminium phosphate complex.Pharmacokinets of Aluminium HydroxideAbsorption- Poorly absorbed.Excretion- Excreted through feces and breast milkOnset of Action for Aluminium HydroxideN/ADuration of Action for Aluminium Hydroxide20 to 180minutesHalf Life of Aluminium HydroxideN/ASide Effects of Aluminium Hydroxide1. Loss of appetite
2. Constipation
3. Hypophosphatemia
4. Osteomalacia
5. Confusion
6. Unusual tiredness or discomfort
7. Muscle weakness
8. Encephalopathy
Contra-indications of Aluminium Hydroxide1. Hypersensitivity to the drug
2. Renal failure
3. Hypertension
4. Heart disease
5. Kidney disease
6. Gastrointestinal bleeding.
Special Precautions while taking Aluminium Hydroxide1. Stomach problems
2. Allergies
Pregnancy Related InformationUse with cautionOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Aluminium Hydroxide1. Gastric hyperacidity
2. Ulcers
3. Digestive disorders
4. Hyperphosphatemia
5. Oesophagitis
6. Hiatal hernia
7. Gastritis
Interactions for Aluminium HydroxideN/ATypical Dosage for Aluminium HydroxideOral-
Acidity and Hyperphosphatemia -
Adult-
500-1500mg tablet or capsule 1 hr after meals and at bed time
5 to 30 ml suspension1 hr after meals and at bed time as needed
Schedule of Aluminium HydroxideN/AStorage Requirements for Aluminium HydroxideStore it at room temperature and away from excess heat and moisture. Refrigerate the suspension. Do not freeze.Effects of Missed Dosage of Aluminium HydroxideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Aluminium HydroxideGive symptomatic and supportive treatmentCalcium
About CalciumCalcium is necessary for cardiac function, muscle contraction, nervous activity, coagulation of blood and for maintaining structural integrity of cell membranes.
Plasma concentration of calcium is kept in normal range by three endocrine factors which control metabolism of calcium. These are (a) Parathyroid hormone, (b) Calcitonin, (c) Vitamin D. Calcium in plasma is bound to albumin, is complexed with anions (e.g. phosphate) and as diffusible ionic calcium. The physiological effects are exerted by ionic calcium. The predominant source of calcium is dairy products and the daily intake varies from 200 - 2500 mg. Adequate calcium intake is particularly important during periods of bone growth in childhood and adolescence and during pregnancy and lactation.
Patients with advanced renal insufficiency exhibit phosphate retention and some degree of hyperphosphataemia. The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy and soft tissue calcification. Calcium acetate, when taken with meals, combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the faeces.
Deficiency signs and symptoms: Osteoporosis, pathological fractures, brittle nails and hair.Mechanism of Action of CalciumCalcium is essential for maintaining the functional integrity of nervous, muscular, and skeletal system. It controls excitability of nerves and muscles and regulates permeability of cell membrane. It also regulates cell adhesion and maintains integrity of cell membrane. Calcium acts as intracellular messenger for hormones, autacoids, and transmitters. It is required for excitation-contraction coupling in all types of muscle and excitation-secretion coupling in exocrine and endocrine glands. It is essential for release of transmitters from nerve endings and other release reactions. It is also essential for impulse generation in heart and determines level of automaticity and
A-V conduction. Calcium is also required for blood-coagulation.
Pharmacokinets of CalciumAbsorption: Actively absorbed from gastrointestinal tract in an ionized form; and vitamin D in it`s active form is required for calcium absorption, Distribution: Distributed mainly in to skeletal tissue (99%) and 1% is distributed equally between the intracellular and extra cellular fluid. CSF levels are about half of the serum calcium levels, Metabolism: Not significantly metabolized in the body, Excretion: Excreted mainly through faeces and a small amount is excreted through urine.Onset of Action for CalciumN/ADuration of Action for CalciumN/AHalf Life of CalciumN/ASide Effects of Calcium1.Constipation
2.Bloating
3.Excess gas
4.Anorexia
5.Nausea
6.Vomiting
7.Abdominal pain
8.Thirst
9.Hypercalcaemia
10.Polyuria
11.Dry mouth
12.Delirium
13.Confusion
Contra-indications of Calcium1.Renal calculi
2.Hypophosphataemia
3.Hypercalcaemia
4.Ventricular fibrillation.
Special Precautions while taking Calcium1.Renal impairment
2.Cardiac diseases
3.Sarcoidosis
4.Cor pulmonale
5.Respiratory acidosis
6.Respiratory failure
7.End stage renal failure
8.Hypoparathyroid patients
9.Digitalized patients
10.Prolonged use of therapeutic amounts.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Calcium1.Hypocalcaemia
2.Calcium and vitamin D deficiency
3.Calcium deficiency during pregnancy and lactation
4.Rickets
5.Prevention of osteoporosis in postmenopausal women
6.Chronic renal failure.
Interactions for CalciumN/ATypical Dosage for CalciumOral: 500mg to 2g daily in two to four divided doses.
Hypocalcaemia:
Adults: 1g daily. Increases to 2g daily if required.
Prevention of osteoporosis: 1 to 1.5g daily.
Children: 45 to 65mg/kg daily.
Neonates: 50 to 150mg/kg and should not exceed 1g.
Schedule of CalciumN/AStorage Requirements for CalciumStore in a well closed container in a cool and dry place. Protect from light.
Effects of Missed Dosage of CalciumTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CalciumRemove calcium from stomach by induced emesis and gastric lavage. Provide symptomatic treatment and supportive measures.Dimethicone
About DimethiconeOral anti -foaming agent, a flexible silicone polymer, Antiflatulent ,Antibloating agent.Mechanism of Action of DimethiconeActivated Dimethicone relieves flatulence by dispensing and preventing formation of mucus surrounding gas pockets in the gastro-intestinal tract. It lowers the surface tension of the gas bubbles and bringing together all the small bubbles of gas (coalesce) to form a large bubble, which is then expelled. Thus the gas is freed by belching or passing flatus.
Antiflatulents are added to an antacid gum coating to be effective antigas materials and eliminate trapped gas. The most common antigas material is Dimethicone and when mixed with silicone dioxide becomes Simethicone. Simethicone is also referred to as activated Dimethicone. Simethicone is the most common antigas material and may be the only drug approved antiflatulent.
As the antacid chewing tablet is chewed, the active antacid and antiflatulent in the gum coating is released into the saliva and ingested to give relief from gastrointestinal disturbances in the gastro-intestinal tract.
Besides its antigas effect, Simethicone used in a gum coating can also improve the smoothness of the coating. Activated Dimethicone helps to relieve pain and bloating caused by trapped wind.
Pharmacokinets of DimethiconeN/AOnset of Action for DimethiconeN/ADuration of Action for DimethiconeN/AHalf Life of DimethiconeN/ASide Effects of DimethiconeN/AContra-indications of DimethiconeHypersensitivity to Dimethicone activatedSpecial Precautions while taking DimethiconeKidney failurePregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Dimethicone1. Flatulent dyspepsia
2. Postoperative distension
3. Gastric Distention
4. Functional digestive disorders
5. Stomach pain
6. Burning
7. Nausea and excess gas (dyspepsia)
Interactions for DimethiconeN/ATypical Dosage for Dimethicone125 - 166 mg taken half an hour before food.
Dimethicone in a coated chewing gum: 5 mg - 200 mg per piece of coated gum.
With an antacid: 20 mg -50 mg of Dimethicone
Schedule of DimethiconeN/AStorage Requirements for DimethiconeStored at room temperature (15-30?C) away from moisture and heat.Effects of Missed Dosage of DimethiconeTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DimethiconeGive symptomatic and supportive treatment.Magnesium Hydroxide
About Magnesium HydroxideMineral, Magnesium compound, Antacid and laxative.Mechanism of Action of Magnesium HydroxideIt neutralize the gastric acid (where the hydroxide ions from the Mg(OH)2 combine with acidic H+ ions produced in the form of hydrochloric acid by parietal cells in the stomach). This relieves the hyperacidity problems in the stomach.Pharmacokinets of Magnesium HydroxideN/AOnset of Action for Magnesium HydroxideN/ADuration of Action for Magnesium HydroxideN/AHalf Life of Magnesium HydroxideN/ASide Effects of Magnesium Hydroxide1. Stomach cramps
2. Upset stomach
3. Vomiting
4. Diarrhea
5. Black/tarry stools
6. Rectal bleeding.
7. Constipation
8. Loss of appetite
9. Unusual tiredness
10. Muscle weakness
11. Hypermagnesaemia
12. Renal failure
Contra-indications of Magnesium Hydroxide1. Hypersensitivity to the drug
2. Kidney disease
3. Stomach/abdominal pain
4. Nausea
5. Vomiting
Special Precautions while taking Magnesium Hydroxide1. Colostomy
2. Dehydration
3. Diarrhea
4. Intestinal problems like colitis
5.Do not take any other medication within 1 to 2 hours of taking this medication.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationLess than 6 Years : ContraindicatedIndications for Magnesium Hydroxide1. Constipation
2. Peptic ulcer
3. Hiatal herniaInteractions for Magnesium HydroxideN/ATypical Dosage for Magnesium HydroxideOral-
Adult-
Antacid:
Tab-500mg to 1.5g daily.
Liquid-5-15ml daily.
Laxative:
Tab-2.4-4.8g daily.
Liquid -30-60ml daily.
Schedule of Magnesium HydroxideN/AStorage Requirements for Magnesium HydroxideStore it at room temperature (15-30 degree C) and away from excess heat and moisture.Effects of Missed Dosage of Magnesium HydroxideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Magnesium HydroxideGive symptomatic and supportive treatment.Home Delivery for Aluminium Hydroxide + Calcium + Dimethicone + Magnesium Hydroxide in Your City
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