Misoprostol Pharmacology

Misoprostol

About Misoprostol

A synthetic prostaglandin E1 (PGE1) analogue, Anti ulcer(antisecretory and protective),Abortifacient.

Mechanism of Action of Misoprostol

Misoprostol is a synthetic Prostaglandin E1 analog. It binds to the EP3 receptor on the basolateral membrane of the parietal cells and stimulates the inhibitory G protein (Gi) receptors. This will leads to decrease in intracellular cyclic AMP level and inhibits proton pump (H+K+ATPase) which exchange the extracellular K+ for intracellular H+ ion. By inhibiting the proton pump Misoprostol decreases gastric acid secretion. Misoprostol also binds to the EP3 receptor on the superficial epithelial cells of the lumen and stimulates the mucin and bicarbonate secretion and decreases nocturnal, basal and stimulated gastric acid secretion.

Pharmacokinets of Misoprostol

Absorption: Misoprostol is well absorbed after oral administration. Distribution: It is distributed in the body in protein bound form. Metabolism: Misoprostol is rapidly undergoes de-esterification and form active metabolite Misoprostol acid. Excretion: Metabolite is excreted mainly in the urine and small amount in the faeces.

Onset of Action for Misoprostol

30 minutes

Duration of Action for Misoprostol

3 hours

Half Life of Misoprostol

20 - 40 minutes

Side Effects of Misoprostol

1.Nausea
2.Vomiting
3.Diarrhoea
4.Abdominal pain
5.Headache
6.Dizziness
7.Dyspepsia
8.Flatulence
9.Constipation
10.Menorrhagia
11.Rashes
12.Dysmenorrhoea

Contra-indications of Misoprostol

1.Hypersensitivity to Misoprostol and other Prostaglandins

Special Precautions while taking Misoprostol

1.Cardiovascular disease
2.Cerebrovascular disease
3.Renal impairment

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Contraindicated
NEONATES: contraindicated

Indications for Misoprostol

1.NSAID induced ulcer
2.Duodenal ulcer
3.Gastric ulcer

Interactions for Misoprostol

Analgesics: Increased risk of CNS toxicity with phenylbutazone.

Typical Dosage for Misoprostol

Adult: NSAID induced ulcer: 200mcg 4 times daily with meals and at bed time for atleast1 month and up to 2 month.
Duodenal ulcer, Gastric ulcer: 400 - 800 mcg/ day in 4 divided doses with meals and at bed time for 1 - 2 month.
Children: not recommended

Schedule of Misoprostol

N/A

Storage Requirements for Misoprostol

Store at 15 - 30 degree C in a tightly closed container. Protect from light.

Effects of Missed Dosage of Misoprostol

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Misoprostol

Give supportive measures and symptomatic treatment.

Home Delivery for Misoprostol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including misoprostol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for misoprostol and other medicines and health products. Home delivery services for misoprostol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take misoprostol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for misoprostol before they complete the sale. You can get this information while placing the order for misoprostol with the pharmacy.

Misoprostol is a generic medicine name and there are several brands available for it. Some of the brands for misoprostol might be better known than misoprostol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have misoprostol in stock, you can ask for one of the branded alternatives for misoprostol.