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- Pharmacology For Rabeprazole + Mosapride
Rabeprazole + Mosapride Pharmacology
Rabeprazole + Mosapride
About Rabeprazole + MosaprideN/AMechanism of Action of Rabeprazole + MosaprideN/APharmacokinets of Rabeprazole + MosaprideN/AOnset of Action for Rabeprazole + MosaprideN/ADuration of Action for Rabeprazole + MosaprideN/AHalf Life of Rabeprazole + MosaprideN/ASide Effects of Rabeprazole + MosaprideN/AContra-indications of Rabeprazole + MosaprideN/ASpecial Precautions while taking Rabeprazole + MosaprideN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Rabeprazole + MosaprideN/AInteractions for Rabeprazole + MosaprideN/ATypical Dosage for Rabeprazole + MosaprideN/ASchedule of Rabeprazole + MosaprideN/AStorage Requirements for Rabeprazole + MosaprideN/AEffects of Missed Dosage of Rabeprazole + MosaprideN/AEffects of Overdose of Rabeprazole + MosaprideN/ARabeprazole
About RabeprazoleBenzimidazole derivative, Proton Pump Inhibitor, Antiulcer.Mechanism of Action of RabeprazoleRabeprazole sodium is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Rabeprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump (H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Rabeprazole sodium irreversibly inhibits proton pumps activity and decreases gastric acid secretion. Rabeprazole produces fastest acid suppression and helps in mucin synthesis.Pharmacokinets of RabeprazoleAbsorption: Rabeprazole sodium is well absorbed after oral administration and its bioavailability is about 50% since it undergoes first pass metabolism. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Rabeprazole sodium is extensively metabolised in the liver. Excretion: It is excreted mainly in the urine and small amount in faeces.Onset of Action for Rabeprazole1hourDuration of Action for Rabeprazole1 dayHalf Life of Rabeprazole1 - 2 hoursSide Effects of Rabeprazole1. Diarrhoea
2. Nausea
3. Headache
4. Vomiting
5. Abdominal pain
6. Dizziness
7. Flatulence
8. Constipation
9. Dyspepsia
10. Flu like syndrome
11. Insomnia
12. Back pain
13. Cough
14. Rhinitis
15. Pharyngitis
16. Rash
Contra-indications of Rabeprazole1. Hypersensitivity to Rabeprazole sodiumSpecial Precautions while taking Rabeprazole1. Hepatic impairment
2. Monitor gastric malignancy
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: ContraindicatedIndications for Rabeprazole1. Active Duodenal ulcer
2. Benign Gastric ulcer
3. Zollinger- Ellison syndrome
4. Erosive Gastroesophageal reflux disease
Interactions for RabeprazoleKetoconazole : Coadministration of rabeprazole sodium results in a 33% decrease in ketoconazole levels.
Digoxin : Increase in trough digoxin levels in normal subjects.
Typical Dosage for RabeprazoleOral
Adult: 10 - 20 mg / day drug to be taken before breakfast.
Duodenal ulcer: 20 mg / day in the morning for 1 month if needed dose can be continuing for 1more month.
Benign Gastric ulcer: 20 mg / day in the morning for 6 weeks if needed dose can be continuing for 6 more weeks.
Zollinger- Ellison syndrome: Initial dose: 60 mg / day if needed increase the dose up to 120 mg / day in 2 divided doses.
Erosive Gastroesophageal reflux disease: 20mg / day for 1-2 months.
Gastroesophageal reflux disease long term management: 10-20 mg once daily before breakfast for 1 year
Children: not recommended
Schedule of RabeprazoleHStorage Requirements for RabeprazoleStore at 15 - 30 degree C in a tightly closed container. Protect from light.Effects of Missed Dosage of RabeprazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of RabeprazoleGive supportive measures and symptomatic treatment.Mosapride
About MosaprideA selective 5HT4 agonist, A gastroprokinetic agent.Mechanism of Action of MosaprideMosapride is a Prokinetic drug. It is a 5 HT4 receptor agonist as well as 5HT3 receptor antagonist in the myenteric plexus. Enterochromaffin cells in the gastrointestinal mucosa produces and releases serotonin in response to stimuli (chemical or mechanical stimulation).Serotonin will enhances peristaltic movement by stimulating sensory neurons in the myenteric plexus. Stimulation of 5HT4 receptors will increase the release of Acetylcholine. The metabolite of Mosapride produces 5HT3 receptor antagonism and suppresses the inhibitory transmission in myenteric plexus. These all results in increased oesophageal peristaltic activity, lower oesophageal sphincter tone and enhances intestinal propulsive activity.Pharmacokinets of MosaprideAbsorption:It is absorbed after oral administration.Excretion: It is excreted mainly urine and faeces.
Onset of Action for MosaprideN/ADuration of Action for MosaprideN/AHalf Life of Mosapride2 - 3 hoursSide Effects of Mosapride1.Diarrhoea
2.Abdominal cramps
3.Headache
4.Dry mouth
5.Nausea
Contra-indications of Mosapride1.Hypersensitivity to MosaprideSpecial Precautions while taking Mosapride1.Hepatic impairment
2.Renal impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicated
NEONATES: contraindicated
Indications for Mosapride1.Gastroesophageal reflux diseases
2.Functional dyspepsia
3.Diabetic gastropathy
4.Disorders associated with decreased gastric motility
5.Nausea
Interactions for MosaprideMosapride`s major degradation system is the cytochrome P450 (3A4) system. However, electrophysiological studies show that coadministration of drugs that inhibit the CYP 3A4 enzymes (erythromycin, ketoconazole, fluconazole, etc.) have no effect on mosapride indicating that a satisfactory safety margin exists in relation to rhythm abnormalities, unlike that which occurs with cisapride. Typical Dosage for MosaprideAdult:
Oral:2.5 - 10 mg every 6 - 8 hours in a day with meals
Children:not recommended
Schedule of MosaprideN/AStorage Requirements for MosaprideStore at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of MosaprideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of MosaprideGive supportive measures and symptomatic treatment.
Home Delivery for Rabeprazole + Mosapride in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for rabeprazole + mosapride and other medicines and health products. Home delivery services for rabeprazole + mosapride may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
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Rabeprazole + Mosapride is a generic medicine name and there are several brands available for it. Some of the brands for rabeprazole + mosapride might be better known than rabeprazole + mosapride itself. If the pharmacy that's willing to deliver medicines to your home doesn't have rabeprazole + mosapride in stock, you can ask for one of the branded alternatives for rabeprazole + mosapride.