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- Pharmacology For Esomeprazole + Domperidone
Esomeprazole + Domperidone Pharmacology
Esomeprazole + Domperidone
About Esomeprazole + DomperidoneN/AMechanism of Action of Esomeprazole + DomperidoneN/APharmacokinets of Esomeprazole + DomperidoneN/AOnset of Action for Esomeprazole + DomperidoneN/ADuration of Action for Esomeprazole + DomperidoneN/AHalf Life of Esomeprazole + DomperidoneN/ASide Effects of Esomeprazole + DomperidoneN/AContra-indications of Esomeprazole + DomperidoneN/ASpecial Precautions while taking Esomeprazole + DomperidoneN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Esomeprazole + DomperidoneN/AInteractions for Esomeprazole + DomperidoneN/ATypical Dosage for Esomeprazole + DomperidoneN/ASchedule of Esomeprazole + DomperidoneN/AStorage Requirements for Esomeprazole + DomperidoneN/AEffects of Missed Dosage of Esomeprazole + DomperidoneN/AEffects of Overdose of Esomeprazole + DomperidoneN/AEsomeprazole
About EsomeprazoleA proton pump inhibitor, Substituted Benzimidazole, Antiulcer, antisecretory drug.Mechanism of Action of EsomeprazoleEsomeprazole is the S enantiomer of Omeprazole and is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Esomeprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump (H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Esomeprazole irreversibly inhibits proton pumps activity and decreases gastric acid secretion. As compared to Omeprazole, Esomeprazole produces better control of intragastric acidity in Gastroesophageal reflux diseases. It is as effective as Omeprazole in other disease condition.Pharmacokinets of EsomeprazoleAbsorption: Esomeprazole is well absorbed after oral administration. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Esomeprazole is extensively metabolised in the liver. Excretion: It is excreted mainly in the urine and small amount in faeces.Onset of Action for EsomeprazoleRapidDuration of Action for EsomeprazoleProlongedHalf Life of Esomeprazole60- 90 minutesSide Effects of Esomeprazole1.Diarrhoea
2.Nausea
3.Abdominal pain
4.Constipation
5.Headache
6.Flatulence
7.Dry mouth
Contra-indications of Esomeprazole1.Gastric ulcer
2.Gastroesophageal reflux disease
3.Oesophagitis
4.NSAID associated ulceration
5.Duodenal ulcer related to H. pylori infection
Special Precautions while taking Esomeprazole1.Hepatic impairment
2.Monitor gastric malignancy
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Esomeprazole1.Gastric ulcer
2.Gastroesophageal reflux disease
3.Oesophagitis
4.NSAID associated ulceration
5.Duodenal ulcer related to H. pylori infection
Interactions for EsomeprazoleEsomeprazole may potentially interfere with CYP2Cl9, the major esomeprazole metabolizing enzyme.
Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (e.g., ketoconazole, iron salts and digoxin). Esomeprazole does not have any clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxycillin.
Typical Dosage for EsomeprazoleGastro-oesophageal Reflux Disease (GORD): Healing of erosive oesophagitis: 20mg or 40mg once daily for 4 to 8 weeks.
Maintenance of healing of erosive esophagitis: 20mg once daily.
Symptomatic gastroesophageal reflux disease: 20mg once daily for 4 weeks.
H. pylori eradication to reduce the risk of duodenal ulcer recurrence
Esomeprazole: 40mg, once daily for 10 days along with Amoxycillin and Clarithromycin
Schedule of EsomeprazoleHStorage Requirements for EsomeprazoleStore at 15 - 30 degree C in a tightly closed container. Protect from light.Effects of Missed Dosage of EsomeprazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of EsomeprazoleGive supportive measures and symptomatic treatment.Domperidone
About DomperidoneAntidopaminergic, Motility stimulant,Piperidine derivative, Antiemetic, anti-vertigo.Mechanism of Action of DomperidoneDomperidone is a potent dopamine receptor antagonist. It acts centrally and blocks the Dopamine receptor in the Chemoreceptor trigger zone and produces Antiemetic effect.
Domperidone acts peripherally in the gastrointestinal system and increases oesophageal peristalsis, oesophageal sphincter pressure and gastric motility. These all facilitates gastric emptying. Domperidone is used in migraine to relieve nausea and vomiting.
Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
Pharmacokinets of DomperidoneAbsorption: Domperidone is rapidly absorbed after oral administration. Since it undergoes first pass metabolism oral bioavailability is only 15 %. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Domperidone undergoes metabolism in the liver. Excretion: It is excreted mainly in the faeces and also in the urine.Onset of Action for Domperidone30 - 60 minutesDuration of Action for Domperidone6 - 8 hoursHalf Life of Domperidone7.5 hoursSide Effects of Domperidone1.Diarrhoea
2.Dry mouth
3.Galactorrhoea
4.Gynaecomastia
5.Skin rash
6.Abdominal discomfort
7.Dystonic reactions
Contra-indications of Domperidone1.Hypersensitivity to Domperidone
2.Prolactin releasing pituitary tumour(prolactinoma)
3.Gastrointestinal obstruction
Special Precautions while taking Domperidone1.Hepatic impairment
2.Renal impairment
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Domperidone1.Nausea and vomiting associated with gastrointestinal disorder and migraine.
2.Delayed gastric emptying of functional origin
3.As an Antiemetic in patient receiving cytotoxic drugs
4.Preanaesthetic medication
Interactions for DomperidoneDigoxin: Oral dose of digoxin needs to be reduced.
Aspirin, Paracetamol & Oral Diazepam: Increases absorption of these agents.
Anticholinergic agents: Antagonize the effects of domperidone.
Phenothiazines: CNS depression enhanced by domperidone.
Antimuscarinic agents and opioids: Antagonize GI effects of domperidone.
Suxamethonium: Neuromuscular blockade enhanced by domperidone.Typical Dosage for DomperidoneAdults: 30 - 40 mg / day in 3 - 4 divided doses 30 minutes before meals and at bed time if required. After 2 weeks dose can be increased to 60 - 80 mg / day if needed.
Migraine: 20 mg by mouth may be taken up to every 4 hours with Paracetamol, as required up to a maximum of 4 doses in 24 hours.
Children: 300 mcg / kg body weight 3 - 4 times daily 30 minutes before meals and at bed time if required
Schedule of DomperidoneHStorage Requirements for DomperidoneStore at room temperature (15 - 30 degree C). Protect from direct sun light and moistureEffects of Missed Dosage of DomperidoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DomperidoneGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage and absorption of the drug can be reduced by administration of activated charcoal. To control Extrapyramidal reactions give antiparkinsonian or anticholinergic agents. Home Delivery for Esomeprazole + Domperidone in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for esomeprazole + domperidone and other medicines and health products. Home delivery services for esomeprazole + domperidone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take esomeprazole + domperidone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for esomeprazole + domperidone before they complete the sale. You can get this information while placing the order for esomeprazole + domperidone with the pharmacy.
Esomeprazole + Domperidone is a generic medicine name and there are several brands available for it. Some of the brands for esomeprazole + domperidone might be better known than esomeprazole + domperidone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have esomeprazole + domperidone in stock, you can ask for one of the branded alternatives for esomeprazole + domperidone.