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- Pharmacology For Ranitidine + Drotaverine
Ranitidine + Drotaverine Pharmacology
Ranitidine + Drotaverine
About Ranitidine + DrotaverineN/AMechanism of Action of Ranitidine + DrotaverineN/APharmacokinets of Ranitidine + DrotaverineN/AOnset of Action for Ranitidine + DrotaverineN/ADuration of Action for Ranitidine + DrotaverineN/AHalf Life of Ranitidine + DrotaverineN/ASide Effects of Ranitidine + DrotaverineN/AContra-indications of Ranitidine + DrotaverineN/ASpecial Precautions while taking Ranitidine + DrotaverineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ranitidine + DrotaverineN/AInteractions for Ranitidine + DrotaverineN/ATypical Dosage for Ranitidine + DrotaverineN/ASchedule of Ranitidine + DrotaverineN/AStorage Requirements for Ranitidine + DrotaverineN/AEffects of Missed Dosage of Ranitidine + DrotaverineN/AEffects of Overdose of Ranitidine + DrotaverineN/ARanitidine
About RanitidineA histamine H2-receptor antagonist, Furan derivative, Anti-secretory G.I agent,Anti ulcer.Mechanism of Action of RanitidineRanitidine is a H2 (Histamine) receptor antagonist. Histamine is the most potent stimulus of acid secretion and acts as the common mediator. H2 receptor is a G-protein coupled receptor. It induces adenylate cyclase which converts ATP to cyclic AMP. This cyclic AMP acts on proton pump and exchange extracellular potassium ion for intracellular hydrogen ion across the parietal cell membrane. Ranitidine reversibly competes with Histamine for binding to H2 receptors on the parietal cells and predominantly inhibits basal acid secretion.
Anaesthetic adjuncts: It is used in patients undergoing prolonged operations, caesarian section,obese patients those are at increased risk of gastric regurgitation and aspiration pneumonia. It raises pH of gastric juice and also reduces its volume and thus chances of regurgitation. It is now routinely used before prolonged surgery.
Pharmacokinets of RanitidineAbsorption: Ranitidine is 50 % absorbed after oral administration. Distribution: Distributed mainly to body tissues in unbound form. Metabolism: Ranitidine undergoes metabolism in the liver. Excretion: It is excreted mainly in urine and in the faeces.Onset of Action for Ranitidine60 minutesDuration of Action for Ranitidine13hoursHalf Life of Ranitidine1.6- 2.4 hoursSide Effects of Ranitidine1. Headache
2. Dizziness
3. Constipation
4. Vertigo
5. Confusion
6. Rash
7. Blurred vision
8. Thrombocytopenia
9. Leukopenia
Contra-indications of Ranitidine1. Hypersensitivity to RanitidineSpecial Precautions while taking Ranitidine1. Hepatic impairment
2. Renal impairment
3. Acute Porphyria
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: Contraindicated
Indications for Ranitidine1. Duodenal ulcer
2. Benign gastric ulcer
3. Zollinger- Ellison syndrome
4. Gastroesophageal reflux
5. Acid indigestion
6. Heart burn
7. Sour stomach
8. Stress ulcers
9. Oesophagitis
10.Preanaesthetic medication
Interactions for RanitidineAntacids: Ranitidine absorption may be decreased.
Diazepam: Efficacy of diazepam decreased.
Procainamide: Renal clearance of procainamide decreased.
Sulfonylureas: Hypoglycemic effects of glipizide enhanced.
Theophyllines: Increased efficacy of theophyllines with possible toxicity.
Warfarin: Increased hypoprothrombinemic effects.
Lab tests: False positive tests for urine proteins with multistix may occur.Typical Dosage for RanitidineAdult: 300mg / day
Duodenal ulcer, benign gastric ulcer: 300 mg /day as single dose at bed time or in 2 divided dose (morning and bed time) for minimum of 4 weeks.
Maintenance dose: 150 mg / day at bed time.
Zollinger- Ellison syndrome: 300 - 450 mg / day in 2 - 3 divided doses; dose can be increased if necessary to a maximum up to 6g / day .
Gastroesophageal reflux: 300 mg / day as single dose at bed time or in 2 divided doses (morning and bed time) for maximum 2 months. In severe conditions dose can be increased to 600 mg / day in 4 divided doses for 3 months
Acid indigestion, Heart burn, Sour stomach: Dose: 75 mg once daily to a maximum up to 150 mg / day.
Oesophagitis: 150 mg/ day.
Dyspepsia: 75 - 300 mg / day depending on the severity of disease.
PAM: 150mg given night and in the morning before surgical procedures.
Children:
Duodenal ulcer, benign gastric ulcer: 4 - 8 mg / kg body weight / day in 2 divided doses.
Maximum dose: 300 mg / day
Schedule of RanitidineHStorage Requirements for RanitidineStore at 15 - 30 degree C in a tightly closed container. Protect from light.Effects of Missed Dosage of RanitidineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of RanitidineGive supportive measures and symptomatic treatment. Drug can be removed from the body by inducing emesis and or by gastric lavage. Activated charcoal is given to reduce the absorption of the drug. Haemodialysis can be done if necessary.Drotaverine
About DrotaverineDrotaverine is an effective spasmolytic drug.Mechanism of Action of DrotaverineDrotaverine has spasmolytic and vasodilating action. It exerts its action by inhibiting phosphodiesterase enzyme IV. This will leads to a decrease in cyclic AMP level and reduction in calcium ions (Ca2+). The reduction of calcium ions will dilates the unstipped muscles and blood vessels strongly and relieves spasm of smooth muscles.Pharmacokinets of DrotaverineAbsorption: Drotaverine is rapidly absorbed after oral administration.
Distribution: It is widely distributed in protein bound form.
Metabolism: Extensively metabolised in the liver.
Excretion: It is excreted mainly with the bile.
Onset of Action for Drotaverine30 minutesDuration of Action for Drotaverine4 hours.Half Life of Drotaverine7 - 12 hoursSide Effects of Drotaverine1.Hypotension
2.Headache
3.Tachycardia
4.Nausea
5.Vertigo
Contra-indications of Drotaverine1.Hypersensitivity to Drotaverine
2.Severe renal impairment
3.Severe hepatic impairment
4.Severe cardiac impairment
Special Precautions while taking Drotaverine1. Renal impairment
2. Hepatic impairment
3. Cardiac impairment.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Drotaverine1.Smooth muscle spasm
2.Gastrointestinal colic pain
3.Renal colic pain
4.Dysmenorrhoea
5.Uterine neck spasm
6.Post MTP(Medical termination of pregnancy)
7.Post D&C(Dilatation and curettage)
8.Post surgical spasm
9.Irritable bowel syndrome
Interactions for DrotaverineN/ATypical Dosage for DrotaverineAdult:
Oral: 120 - 240 mg / day in 3 divided doses.
Children: 60 - 120 mg / day in 3 divided doses, dose is depending upon the age of the patient.
Parenteral (IM)
Induction of labour: 40 mg every 2 hours, maximum 3 doses.
Schedule of DrotaverineN/AStorage Requirements for DrotaverineStore in a cool dry place. Protect from heat and light.
Keep out of the reach of children
Effects of Missed Dosage of DrotaverineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DrotaverineGive supportive measures and symptomatic treatment.Home Delivery for Ranitidine + Drotaverine in Your City
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Ranitidine + Drotaverine is a generic medicine name and there are several brands available for it. Some of the brands for ranitidine + drotaverine might be better known than ranitidine + drotaverine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ranitidine + drotaverine in stock, you can ask for one of the branded alternatives for ranitidine + drotaverine.