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- Pharmacology For Famotidine + Domperidone
Famotidine + Domperidone Pharmacology
Famotidine + Domperidone
About Famotidine + DomperidoneN/AMechanism of Action of Famotidine + DomperidoneN/APharmacokinets of Famotidine + DomperidoneN/AOnset of Action for Famotidine + DomperidoneN/ADuration of Action for Famotidine + DomperidoneN/AHalf Life of Famotidine + DomperidoneN/ASide Effects of Famotidine + DomperidoneN/AContra-indications of Famotidine + DomperidoneN/ASpecial Precautions while taking Famotidine + DomperidoneN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Famotidine + DomperidoneN/AInteractions for Famotidine + DomperidoneN/ATypical Dosage for Famotidine + DomperidoneN/ASchedule of Famotidine + DomperidoneN/AStorage Requirements for Famotidine + DomperidoneN/AEffects of Missed Dosage of Famotidine + DomperidoneN/AEffects of Overdose of Famotidine + DomperidoneN/AFamotidine
About FamotidineGuanidine:Thiazole derivative,a histamine H2-receptor antagonist, Anti-secretory,Antiulcer.Mechanism of Action of FamotidineFamotidine is a H2 (Histamine) receptor antagonist. Histamine is the most potent stimulus of acid secretion and acts as the common mediator. H2 receptor is a G-protein coupled receptor. It induces adenylate cyclase which converts ATP to cyclic AMP. This cyclic AMP acts on proton pump and exchange extracellular potassium ion for intracellular hydrogen ion across the parietal cell membrane. Famotidine reversibly competes with Histamine for binding to H2 receptors on the parietal cells and predominantly inhibits basal acid secretion.
Anaesthetic adjuncts: It is used in patients undergoing prolonged operations, caesarian section; obese patients are at increased risk of gastric regurgitation and aspiration pneumonia. It raises pH of gastric juice and also reduces its volume and thus chances of regurgitation. It is now routinely used before prolonged surgery.
Pharmacokinets of FamotidineAbsorption: Famotidine is 40 - 45 % absorbed after oral administration. Distribution: Distributed mainly in unbound form. Metabolism: Famotidine undergoes metabolism in the liver. Excretion: It is excreted mainly in urine and in the faeces.Onset of Action for Famotidine60 minutesDuration of Action for Famotidine2.5-3.5 hoursHalf Life of Famotidine2.5 - 3.5 hoursSide Effects of Famotidine1.Headache
2.Dizziness
3.Constipation
4.Diarrhoea
5.Nausea
6.Vertigo
7.Confusion
8.Rash
9.Thrombocytopenia
10.Leukopenia
Contra-indications of Famotidine1. Hypersensitivity to FamotidineSpecial Precautions while taking Famotidine1.Hepatic impairment
2.Renal impairment
3.Acute Porphyria
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with caution.
NEONATES: contraindicatedIndications for Famotidine1.Duodenal ulcer
2.Benign gastric ulcer
3.Zollinger- Ellison syndrome
4.Gastroesophageal reflux diseases
5.Acid indigestion
6.Heart burn
7.Sour stomach
8.Preanaesthetic medication (PAM)
Interactions for FamotidineAntacids: Bioavailability of Famotidine slightly decreased, hence antacids in small doses can be given concomitantly.Typical Dosage for FamotidineAdult: 40mg / day
Duodenal ulcer, benign gastric ulcer: 40 mg /day as single dose at bed time or in 2 divided dose (morning and bed time) for 1 - 2 months. Maintenance dose: 20 mg / day at bed time.
Zollinger- Ellison syndrome: 80mg / day in 4 divided doses; dose can be increased if necessary to a maximum up to 800 mg / day
Gastroesophageal reflux disease: 40 mg / day as single dose at bed time or in 2 divided doses (morning and bed time) for maximum 2-3 months, dose can be increased to 80 mg / day in 2 divided doses if needed.
Acid indigestion, Heart burn, Sour stomach: Dose: 20mg/day in 2 divided doses.
PAM: 20mg given night before and in the morning before surgical procedure.
Schedule of FamotidineHStorage Requirements for FamotidineStore at 15 - 30 degree C in a tightly closed container. Protect from light.Effects of Missed Dosage of FamotidineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of FamotidineGive supportive measures and symptomatic treatment. Drug can be removed from the body by inducing emesis and or by gastric lavage. Activated charcoal is given to reduce the absorption of the drug. Haemodialysis can be done if necessary.Domperidone
About DomperidoneAntidopaminergic, Motility stimulant,Piperidine derivative, Antiemetic, anti-vertigo.Mechanism of Action of DomperidoneDomperidone is a potent dopamine receptor antagonist. It acts centrally and blocks the Dopamine receptor in the Chemoreceptor trigger zone and produces Antiemetic effect.
Domperidone acts peripherally in the gastrointestinal system and increases oesophageal peristalsis, oesophageal sphincter pressure and gastric motility. These all facilitates gastric emptying. Domperidone is used in migraine to relieve nausea and vomiting.
Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
Pharmacokinets of DomperidoneAbsorption: Domperidone is rapidly absorbed after oral administration. Since it undergoes first pass metabolism oral bioavailability is only 15 %. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Domperidone undergoes metabolism in the liver. Excretion: It is excreted mainly in the faeces and also in the urine.Onset of Action for Domperidone30 - 60 minutesDuration of Action for Domperidone6 - 8 hoursHalf Life of Domperidone7.5 hoursSide Effects of Domperidone1.Diarrhoea
2.Dry mouth
3.Galactorrhoea
4.Gynaecomastia
5.Skin rash
6.Abdominal discomfort
7.Dystonic reactions
Contra-indications of Domperidone1.Hypersensitivity to Domperidone
2.Prolactin releasing pituitary tumour(prolactinoma)
3.Gastrointestinal obstruction
Special Precautions while taking Domperidone1.Hepatic impairment
2.Renal impairment
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Domperidone1.Nausea and vomiting associated with gastrointestinal disorder and migraine.
2.Delayed gastric emptying of functional origin
3.As an Antiemetic in patient receiving cytotoxic drugs
4.Preanaesthetic medication
Interactions for DomperidoneDigoxin: Oral dose of digoxin needs to be reduced.
Aspirin, Paracetamol & Oral Diazepam: Increases absorption of these agents.
Anticholinergic agents: Antagonize the effects of domperidone.
Phenothiazines: CNS depression enhanced by domperidone.
Antimuscarinic agents and opioids: Antagonize GI effects of domperidone.
Suxamethonium: Neuromuscular blockade enhanced by domperidone.Typical Dosage for DomperidoneAdults: 30 - 40 mg / day in 3 - 4 divided doses 30 minutes before meals and at bed time if required. After 2 weeks dose can be increased to 60 - 80 mg / day if needed.
Migraine: 20 mg by mouth may be taken up to every 4 hours with Paracetamol, as required up to a maximum of 4 doses in 24 hours.
Children: 300 mcg / kg body weight 3 - 4 times daily 30 minutes before meals and at bed time if required
Schedule of DomperidoneHStorage Requirements for DomperidoneStore at room temperature (15 - 30 degree C). Protect from direct sun light and moistureEffects of Missed Dosage of DomperidoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DomperidoneGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage and absorption of the drug can be reduced by administration of activated charcoal. To control Extrapyramidal reactions give antiparkinsonian or anticholinergic agents. Home Delivery for Famotidine + Domperidone in Your City
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