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- Pharmacology For Calcium + Calcitriol + Zinc + Magnesium + Sodium Borate
Calcium + Calcitriol + Zinc + Magnesium + Sodium Borate Pharmacology
Calcium + Calcitriol + Zinc + Magnesium + Sodium Borate
About Calcium + Calcitriol + Zinc + Magnesium + Sodium BorateN/AMechanism of Action of Calcium + Calcitriol + Zinc + Magnesium + Sodium BorateN/APharmacokinets of Calcium + Calcitriol + Zinc + Magnesium + Sodium BorateN/AOnset of Action for Calcium + Calcitriol + Zinc + Magnesium + Sodium BorateN/ADuration of Action for Calcium + Calcitriol + Zinc + Magnesium + Sodium BorateN/AHalf Life of Calcium + Calcitriol + Zinc + Magnesium + Sodium BorateN/ASide Effects of Calcium + Calcitriol + Zinc + Magnesium + Sodium BorateN/AContra-indications of Calcium + Calcitriol + Zinc + Magnesium + Sodium BorateN/ASpecial Precautions while taking Calcium + Calcitriol + Zinc + Magnesium + Sodium BorateN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Calcium + Calcitriol + Zinc + Magnesium + Sodium Borate1.Post-menopausal osteoporosis.
2.Rickets
3.Osteocalcaemia
4.Osteoporosis in males
Interactions for Calcium + Calcitriol + Zinc + Magnesium + Sodium BorateN/ATypical Dosage for Calcium + Calcitriol + Zinc + Magnesium + Sodium BorateAdult: 1 capsule / day and if needed dose can be increased by 1 capsule every 2 weekSchedule of Calcium + Calcitriol + Zinc + Magnesium + Sodium BorateN/AStorage Requirements for Calcium + Calcitriol + Zinc + Magnesium + Sodium BorateN/AEffects of Missed Dosage of Calcium + Calcitriol + Zinc + Magnesium + Sodium BorateN/AEffects of Overdose of Calcium + Calcitriol + Zinc + Magnesium + Sodium BorateN/ACalcium
About CalciumCalcium is necessary for cardiac function, muscle contraction, nervous activity, coagulation of blood and for maintaining structural integrity of cell membranes.
Plasma concentration of calcium is kept in normal range by three endocrine factors which control metabolism of calcium. These are (a) Parathyroid hormone, (b) Calcitonin, (c) Vitamin D. Calcium in plasma is bound to albumin, is complexed with anions (e.g. phosphate) and as diffusible ionic calcium. The physiological effects are exerted by ionic calcium. The predominant source of calcium is dairy products and the daily intake varies from 200 - 2500 mg. Adequate calcium intake is particularly important during periods of bone growth in childhood and adolescence and during pregnancy and lactation.
Patients with advanced renal insufficiency exhibit phosphate retention and some degree of hyperphosphataemia. The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy and soft tissue calcification. Calcium acetate, when taken with meals, combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the faeces.
Deficiency signs and symptoms: Osteoporosis, pathological fractures, brittle nails and hair.Mechanism of Action of CalciumCalcium is essential for maintaining the functional integrity of nervous, muscular, and skeletal system. It controls excitability of nerves and muscles and regulates permeability of cell membrane. It also regulates cell adhesion and maintains integrity of cell membrane. Calcium acts as intracellular messenger for hormones, autacoids, and transmitters. It is required for excitation-contraction coupling in all types of muscle and excitation-secretion coupling in exocrine and endocrine glands. It is essential for release of transmitters from nerve endings and other release reactions. It is also essential for impulse generation in heart and determines level of automaticity and
A-V conduction. Calcium is also required for blood-coagulation.
Pharmacokinets of CalciumAbsorption: Actively absorbed from gastrointestinal tract in an ionized form; and vitamin D in it`s active form is required for calcium absorption, Distribution: Distributed mainly in to skeletal tissue (99%) and 1% is distributed equally between the intracellular and extra cellular fluid. CSF levels are about half of the serum calcium levels, Metabolism: Not significantly metabolized in the body, Excretion: Excreted mainly through faeces and a small amount is excreted through urine.Onset of Action for CalciumN/ADuration of Action for CalciumN/AHalf Life of CalciumN/ASide Effects of Calcium1.Constipation
2.Bloating
3.Excess gas
4.Anorexia
5.Nausea
6.Vomiting
7.Abdominal pain
8.Thirst
9.Hypercalcaemia
10.Polyuria
11.Dry mouth
12.Delirium
13.Confusion
Contra-indications of Calcium1.Renal calculi
2.Hypophosphataemia
3.Hypercalcaemia
4.Ventricular fibrillation.
Special Precautions while taking Calcium1.Renal impairment
2.Cardiac diseases
3.Sarcoidosis
4.Cor pulmonale
5.Respiratory acidosis
6.Respiratory failure
7.End stage renal failure
8.Hypoparathyroid patients
9.Digitalized patients
10.Prolonged use of therapeutic amounts.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Calcium1.Hypocalcaemia
2.Calcium and vitamin D deficiency
3.Calcium deficiency during pregnancy and lactation
4.Rickets
5.Prevention of osteoporosis in postmenopausal women
6.Chronic renal failure.
Interactions for CalciumN/ATypical Dosage for CalciumOral: 500mg to 2g daily in two to four divided doses.
Hypocalcaemia:
Adults: 1g daily. Increases to 2g daily if required.
Prevention of osteoporosis: 1 to 1.5g daily.
Children: 45 to 65mg/kg daily.
Neonates: 50 to 150mg/kg and should not exceed 1g.
Schedule of CalciumN/AStorage Requirements for CalciumStore in a well closed container in a cool and dry place. Protect from light.
Effects of Missed Dosage of CalciumTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CalciumRemove calcium from stomach by induced emesis and gastric lavage. Provide symptomatic treatment and supportive measures.Calcitriol
About CalcitriolN/AMechanism of Action of CalcitriolCalcitriol is a 1, 25-dihydroxycholecalciferol or a Vitamin D analogue. It increases the absorption of Calcium from intestine by forming a calcium binding protein. It reverses the signs of rickets and osteomalacia.Pharmacokinets of CalcitriolAbsorption: It is readily absorbed after oral administration. Distribution: It is widely distributed in protein bound form. Metabolism: It undergoes metabolism in the liver and kidney. Excretion: It is excreted mainly in the faeces.Onset of Action for Calcitriol2 - 6 hoursDuration of Action for Calcitriol3 - 5 daysHalf Life of Calcitriol3 - 8 hoursSide Effects of Calcitriol1. Nausea
2. Vomiting
3. Constipation
4. Headache
5. Somnolence
6. Weakness
7. Hypertension
8. Bone and muscle pain
9. Pruritus
10. Weight loss
11. Polyuria
12. Metallic taste
13. Anorexia
14. Dry mouth
Contra-indications of Calcitriol1. Hypercalcaemia
2. Metastatic calcification
3. Plasma phosphorus level greater than 6 mg/dl
Special Precautions while taking Calcitriol1.Liver impairment
2.Renal impairment
3.Monitor plasma calcium and creatinine in patients receiving high doses
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Calcitriol1.Management of Hypocalcaemia
2.Management of hypoparathyroidism and pseudohypoparathyroidismInteractions for CalcitriolN/ATypical Dosage for CalcitriolAdult:
Oral:
Management of hypocalcaemia:0.25mcg/day.Dosage can be increased by 0.25mcg/day at 1 - 2 month interval.Maintenance dose:0.25 - 1 mcg/ day.
Management of hypoparathyroidism and psedohypothyroidism:0.25mcg/day in the morning and dosage can be incresed at 2 - 4 week intervals.Maintenance dose: 0.5 - 2 mcg/day
Children:above 6 years:same as adult dose
Children 1 - 5 years: 0.25 - 0.75mcg/day Schedule of CalcitriolN/AStorage Requirements for CalcitriolStore in a well closed container.Protect from heat,light and moisture.Keep out of the reach of children.Effects of Missed Dosage of CalcitriolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Do not double the dose.Continue the regular schedule.Effects of Overdose of CalcitriolGive supportive mesures and symptomatic treatment. Zinc
About ZincTrance metal, Dietary mineral, Nutritional supplement,Treatment of zinc deficiency,in wound healing.Mechanism of Action of ZincZinc acts as a cofactor for more than 70 different enzymes. Zinc dependent enzymes are involved in the metabolism of carbohydrates, lipids, and proteins. Zinc facilitates wound healing, normal growth rates, normal skin hydration and maintains senses of taste and smell. It provides normal growth and tissue repair. It also helps in development of cell mediated immunity.Pharmacokinets of ZincAbsorption: Poorly absorbed orally, Distribution: Zinc is distributed mainly in to skeletal muscle, skin, bone, pancreas, kidney, liver, retina, prostate, RBC, and WBC. Excretion: Excreted mainly through intestine; only 2% loss in the urine.Onset of Action for ZincN/ADuration of Action for ZincN/AHalf Life of ZincN/ASide Effects of Zinc1. Nausea
2. Vomiting
3. Abdominal distress
4. Gastric ulceration
5. Rashes
Contra-indications of ZincN/ASpecial Precautions while taking Zinc1.Don`t exceed prescribed dose
2.Renal failure
3.Biliary obstruction
Pregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Zinc1. Zinc deficiency
2. Acne vulgaris
3. Chronic skin ulcers
4. Adjunct to antimicrobials
5. Delayed wound healing
6. Alopecia
Interactions for ZincFluoroquinolones, Tetracyclines: Decreased GI absorption and serum levels of some fluoroquinolone.
Pencillamine: Reduced absorption of zinc.
Iron: Reduced absorption of iron and vice versa.
Typical Dosage for ZincAdults: 25 to 50mg zinc daily or 1 to 2 tablets daily.
Children: 5mg/kg 1 to 3 times daily.
Schedule of ZincN/AStorage Requirements for ZincStore at a temperature below 30 degree CEffects of Missed Dosage of ZincTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ZincProvide symptomatic treatment and supportive measuresMagnesium
About MagnesiumMagnesium is essential for enzyme activity, calcium and potassium uptake, nerve transmission, bone formation and metabolism of carbohydrates and minerals. It is magnesium, not calcium, which helps form hard tooth enamel, resistant to decay. Like calcium and chloride, magnesium also plays a role in regulating the acid-alkaline balance in the body. High magnesium levels in drinking water have been linked to resistance to heart disease. Although it is found in many foods, including dairy products, nuts, vegetables, fish, meat and seafood, deficiencies are common in America due to soil depletion, poor absorption and lack of minerals in drinking water. A diet high in carbohydrates, oxalic acid in foods like raw spinach and phytic acid found in whole grains can cause deficiencies. An excellent source of usable magnesium is beef, chicken or fish broth. High amounts of zinc and vitamin D increase magnesium requirements. Magnesium deficiency can result in coronary heart disease, chronic weight loss, obesity, fatigue, epilepsy and impaired brain function. Chocolate cravings are a sign of magnesium deficiency.Mechanism of Action of MagnesiumN/APharmacokinets of MagnesiumN/AOnset of Action for MagnesiumN/ADuration of Action for MagnesiumN/AHalf Life of MagnesiumN/ASide Effects of MagnesiumN/AContra-indications of MagnesiumN/ASpecial Precautions while taking MagnesiumN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for MagnesiumN/AInteractions for MagnesiumN/ATypical Dosage for MagnesiumN/ASchedule of MagnesiumN/AStorage Requirements for MagnesiumN/AEffects of Missed Dosage of MagnesiumN/AEffects of Overdose of MagnesiumN/ASodium borate
About Sodium borateBoron compound, Cleaning product, mild antiseptic.Mechanism of Action of Sodium borateN/APharmacokinets of Sodium borateN/AOnset of Action for Sodium borateN/ADuration of Action for Sodium borateN/AHalf Life of Sodium borateN/ASide Effects of Sodium borateN/AContra-indications of Sodium borateN/ASpecial Precautions while taking Sodium borateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Sodium borateN/AInteractions for Sodium borateN/ATypical Dosage for Sodium borateN/ASchedule of Sodium borateN/AStorage Requirements for Sodium borateN/AEffects of Missed Dosage of Sodium borateN/AEffects of Overdose of Sodium borateN/AHome Delivery for Calcium + Calcitriol + Zinc + Magnesium + Sodium Borate in Your City
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