Etidronate Sodium Pharmacology

Etidronate Sodium

About Etidronate Sodium
Bisphosphonate Derivative, Antihypercalcemic, Bone resorption inhibitor.
Mechanism of Action of Etidronate Sodium
This bisphosphonate drug localize in the acidic zone under osteoclasts due to their high affinity for Ca2+ ions. When Ca2+ ions are released from bone surface due to high acidity, this drug also released and internalized into osteoclasts by endocytosis. These results
1. Apoptosis of osteoclasts which reduce their number
2. Disruption of cytoskeleton and ruffled border of osteoclasts
Pharmacokinets of Etidronate Sodium
Absorption- Poorly absorbed after oral and intravenous administration
Distribution- Widely distributed into the bone
Metabolism- Drug is not metabolized
Excretion- Excreted through feces
Onset of Action for Etidronate Sodium
Intravenous- 24 hrs
Oral- 1month
Duration of Action for Etidronate Sodium
N/A
Half Life of Etidronate Sodium
Plasma half-life is 6 hours and half-life in bone is 90 days
Side Effects of Etidronate Sodium
1. Gastric irritation
2. Bone pain
3. Headache
4. Metallic taste
5. Pyrexia
6. Hypersensitivity
7. Nausea
8. Diarrhoea
9. Blood dyscriasis
10. Seizures
Contra-indications of Etidronate Sodium
1. Hypersensitivity to the drug or any ingredients of it
2. Osteomalacia
3. Significant lytic lesions or lytic lesions involving crucial bones
Special Precautions while taking Etidronate Sodium
1. Peptic ulcer
2. Enterocolitis
3. Renal impairment
4. Fracture
5. Adequate intake of calcium and Vit D and good nutrition status is required during etidronate therapy. Re-treatment should be done after 3 months drug free interval. Continuous administration of medication of periods greater than 6 months in Paget`s disease increases the risk of fracture.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Etidronate Sodium
1. Ossification
2. Hypercalcemia of malignancy
3. Paget`s disease of bone
4. Ectopic calcification
Interactions for Etidronate Sodium
Calcium supplements, antacids: Absorption of etidronate decreased.
Typical Dosage for Etidronate Sodium
Oral-
Adult-
Paget`s disease:5 mg/kg body weight/day not to exceed six months
Ossification:20mg/kg/day for 2 weeks and then 10mg/kg/day for 10 weeks
Hypercalcemia: 7.5 mg/kg/day for 3 to 7 days, treatment repeated 2nd course of treatment after 7 days
Schedule of Etidronate Sodium
N/A
Storage Requirements for Etidronate Sodium
Store at room temperature away from light and heat. Keep out of reach of children
Effects of Missed Dosage of Etidronate Sodium
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Etidronate Sodium
Give symptomatic and supportive treatment. Induce emesis or gastric lavage. Administer calcium if needed.

Home Delivery for Etidronate Sodium in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for etidronate sodium and other medicines and health products. Home delivery services for etidronate sodium may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

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Etidronate Sodium is a generic medicine name and there are several brands available for it. Some of the brands for etidronate sodium might be better known than etidronate sodium itself. If the pharmacy that's willing to deliver medicines to your home doesn't have etidronate sodium in stock, you can ask for one of the branded alternatives for etidronate sodium.