Dantrolene sodium Pharmacology

Dantrolene sodium

About Dantrolene sodium
N/A
Mechanism of Action of Dantrolene sodium
Dantrolene is s skeletal muscle relaxant which differs from the classical neuromuscular blocking drugs. It inhibits the release of Calcium from sarcoplasmic reticulam and suppresses excitation contraction coupling. It reduces the calcium level associated with malignant hyperthermia crises.
Pharmacokinets of Dantrolene sodium
Absorption: Bioavailability is only 35% after oral administration. Metabolism: It rapidly undergoes hydrolysis by pseudocholinesterase enzyme in the liver. Excretion: Metabolites are excreted mainly in urine and bile.
Onset of Action for Dantrolene sodium
N/A
Duration of Action for Dantrolene sodium
N/A
Half Life of Dantrolene sodium
9hour
Side Effects of Dantrolene sodium
1.Dizziness
2.Drowsiness
3.Light headedness
4.Malaise
5.Fatigue
6.Headache
7.Confusion
8.Nervousness
9.Insomnia
10.Tachycardia
11.Anorexia
12.Constipation
13.Diarrhoea
14.Urinary frequency
15.Dysuria
16.Hepatitis
17.Myalgia
18.Diaphoresis
19.Chills
20.Urticaria
21.Pruritus


Contra-indications of Dantrolene sodium
1.Hypersensitivity to Dantrolene
2.Spasms in Rheumatic disorder
3.Liver disease
Special Precautions while taking Dantrolene sodium
1.Cardiac disease
2.Impaired pulmonary function
3.Patient on Estrogen therapy
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
May be used
Below age 5 :Use with caution
Indications for Dantrolene sodium
1. Spasticity resulting from upper motor neuron lesions such as spinal cord injury, stroke, multiple sclerosis, cerebral palsy
Interactions for Dantrolene sodium
N/A
Typical Dosage for Dantrolene sodium
Oral
Adult: 25mg/day if needed dose can be increased by 25mg every 4 - 7 days up to 400mg/day in 4 divided doses.
Children
Above 5 years: 0.5mg/kg 2 times daily, if needed dose can be gradually increased by 0.5mg/kg up to 3mg/kg 2 - 4 times daily. Maximum dose: 400 mg/day
Schedule of Dantrolene sodium
N/A
Storage Requirements for Dantrolene sodium
Store at room temperature below 25 degree C in a well closed container. Protect from moisture. Keep out of reach of children
Effects of Missed Dosage of Dantrolene sodium
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dantrolene sodium
Provide symptomatic treatment and supportive measures. Gastric lavage can be done to remove the drugs.

Home Delivery for Dantrolene sodium in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dantrolene sodium and other medicines and health products. Home delivery services for dantrolene sodium may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dantrolene sodium only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dantrolene sodium before they complete the sale. You can get this information while placing the order for dantrolene sodium with the pharmacy.

Dantrolene sodium is a generic medicine name and there are several brands available for it. Some of the brands for dantrolene sodium might be better known than dantrolene sodium itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dantrolene sodium in stock, you can ask for one of the branded alternatives for dantrolene sodium.