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- Pharmacology For Tizanidine + Rofecoxib
Tizanidine + Rofecoxib Pharmacology
Tizanidine + Rofecoxib
About Tizanidine + RofecoxibN/AMechanism of Action of Tizanidine + RofecoxibN/APharmacokinets of Tizanidine + RofecoxibN/AOnset of Action for Tizanidine + RofecoxibN/ADuration of Action for Tizanidine + RofecoxibN/AHalf Life of Tizanidine + RofecoxibN/ASide Effects of Tizanidine + RofecoxibN/AContra-indications of Tizanidine + RofecoxibN/ASpecial Precautions while taking Tizanidine + RofecoxibN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Tizanidine + RofecoxibN/AInteractions for Tizanidine + RofecoxibN/ATypical Dosage for Tizanidine + RofecoxibN/ASchedule of Tizanidine + RofecoxibN/AStorage Requirements for Tizanidine + RofecoxibN/AEffects of Missed Dosage of Tizanidine + RofecoxibN/AEffects of Overdose of Tizanidine + RofecoxibN/ATizanidine
About TizanidineA centrally acting a-2 adrenergic agonist, Centrally acting muscle relaxant (short-acting).Mechanism of Action of TizanidineThis drug is a centrally acting alpha2 agonist at alpha2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. This results the blocking of nerve impulses (or pain sensations) that are sent to your brain.Pharmacokinets of TizanidineAbsorption- Completely absorbed after oral administration.
Distribution- Widely distributed throughout the body. 30% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites.
Excretion- Excreted through urine.
Onset of Action for Tizanidine1 to 2 hrs after oral administrationDuration of Action for TizanidineN/AHalf Life of TizanidineN/ASide Effects of Tizanidine1. Dizziness
2. Upset stomach
3. Vomiting
4. Tingling sensation in the arms, legs, hands, and feet
5. Dry mouth
6. Increased muscle spasms
7. Yellowing of the skin or eyes
8. Unexplained flu-like symptoms
Contra-indications of Tizanidine1. Contraindicated in patients with hypersensitivity to the drug or any ingredients of itSpecial Precautions while taking Tizanidine1. Kidney disease
2. Liver disease
3. Low blood pressure or are on medication to treat high blood pressure
4. Birth control pills use
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Tizanidine1. Painful muscle spasm associated with static and functional disorders of the spine
2. Following surgery for disc prolapse/osteoarthritis of the hipInteractions for TizanidineAlcohol & other CNS depressants : CNS effects of tizanidine potentiated.Typical Dosage for TizanidineOral-
Adult-
Muscle spasm - 2 mg thrice a day.
Spasticity- Initial dose 6 mg/day in 3 divided doses, then increase stepwise to 12-36 mg/day.
Schedule of TizanidineN/AStorage Requirements for TizanidineStore at room temperature away from moisture and heat.Effects of Missed Dosage of TizanidineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TizanidineGive symptomatic and supportive treatment.Rofecoxib
About RofecoxibNSAID,Selective COX-2 inhibitor, Analgesic ,anti-inflammatory.Mechanism of Action of RofecoxibRofecoxib inhibits prostaglandin synthesis by inhibiting COX2 enzyme. This NSAID inhibit COX2 enzyme selectively (COX-2 is only produced in response to tissue injury and causes tissue inflammation, and thus pain. It works converting arachidonic acid into a specific prostaglandin which communicates the need for inflammation to the surrounding tissue). This results the anti-inflammatory actionPharmacokinets of RofecoxibAbsorption- Well absorbed after oral administration
Distribution- Widely distributed in the body as its plasma protein bound form. Metabolism-It is metabolized in the liver to inactive metabolites.Excretion- Excreted through urine
Onset of Action for RofecoxibN/ADuration of Action for RofecoxibN/AHalf Life of Rofecoxib17 hoursSide Effects of Rofecoxib. Diarrhea
2. Constipation
3. Sore throat
4. Cough
5. Runny nose
6. Fever
7. Blisters
8. Hives
9. Itching
10. Swelling
11. Difficulty in breathing or swallowing
12. Hoarseness
13. Pale skin
14. Fast heartbeat
15. Weight gain
16. Upset stomach
17. Tiredness
18. Pain in the right upper part of the stomach
19. Flu-like symptoms
20. Cloudy, discolored, or bloody urine
21. Back pain
22. Difficult or painful urination
Contra-indications of Rofecoxib1. Hypersensitivity to the drug.
2. Hepatic insufficiency.
3. Renal insufficiency
Special Precautions while taking Rofecoxib1. Alcohol abuse
2. Bleeding problems
3. Stomach ulcer
4. Tobacco abuse
5. Anemia
6. Asthma
7. Dehydration
8. Fluid retention (swelling of feet or lower legs)
9. High blood pressure
10. Coronary artery bypass graft (CABG) surgery
11. Heart disease
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Rofecoxib1. Dysmenorrhea (pain with your menstrual period)
2. Osteoarthritis
Interactions for RofecoxibN/ATypical Dosage for RofecoxibOral-
Adults-
Osteoarthritis: 12.5mg day and if needed dose can be increased to 25mg/day
Dysmenorrhea- 50mg/day for upto 5 days
Schedule of RofecoxibN/AStorage Requirements for RofecoxibStore at room temperature.Keep away from moisture and heatEffects of Missed Dosage of RofecoxibTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of RofecoxibGive supportive measures and symptomatic treatment. Home Delivery for Tizanidine + Rofecoxib in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tizanidine + rofecoxib and other medicines and health products. Home delivery services for tizanidine + rofecoxib may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take tizanidine + rofecoxib only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tizanidine + rofecoxib before they complete the sale. You can get this information while placing the order for tizanidine + rofecoxib with the pharmacy.
Tizanidine + Rofecoxib is a generic medicine name and there are several brands available for it. Some of the brands for tizanidine + rofecoxib might be better known than tizanidine + rofecoxib itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tizanidine + rofecoxib in stock, you can ask for one of the branded alternatives for tizanidine + rofecoxib.