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- Pharmacology For Tizanidine + Mefenamic acid
Tizanidine + Mefenamic acid Pharmacology
Tizanidine + Mefenamic acid
About Tizanidine + Mefenamic acidN/AMechanism of Action of Tizanidine + Mefenamic acidN/APharmacokinets of Tizanidine + Mefenamic acidN/AOnset of Action for Tizanidine + Mefenamic acidN/ADuration of Action for Tizanidine + Mefenamic acidN/AHalf Life of Tizanidine + Mefenamic acidN/ASide Effects of Tizanidine + Mefenamic acidN/AContra-indications of Tizanidine + Mefenamic acidN/ASpecial Precautions while taking Tizanidine + Mefenamic acidN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Tizanidine + Mefenamic acidN/AInteractions for Tizanidine + Mefenamic acidN/ATypical Dosage for Tizanidine + Mefenamic acidN/ASchedule of Tizanidine + Mefenamic acidN/AStorage Requirements for Tizanidine + Mefenamic acidN/AEffects of Missed Dosage of Tizanidine + Mefenamic acidN/AEffects of Overdose of Tizanidine + Mefenamic acidN/ATizanidine
About TizanidineA centrally acting a-2 adrenergic agonist, Centrally acting muscle relaxant (short-acting).Mechanism of Action of TizanidineThis drug is a centrally acting alpha2 agonist at alpha2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. This results the blocking of nerve impulses (or pain sensations) that are sent to your brain.Pharmacokinets of TizanidineAbsorption- Completely absorbed after oral administration.
Distribution- Widely distributed throughout the body. 30% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites.
Excretion- Excreted through urine.
Onset of Action for Tizanidine1 to 2 hrs after oral administrationDuration of Action for TizanidineN/AHalf Life of TizanidineN/ASide Effects of Tizanidine1. Dizziness
2. Upset stomach
3. Vomiting
4. Tingling sensation in the arms, legs, hands, and feet
5. Dry mouth
6. Increased muscle spasms
7. Yellowing of the skin or eyes
8. Unexplained flu-like symptoms
Contra-indications of Tizanidine1. Contraindicated in patients with hypersensitivity to the drug or any ingredients of itSpecial Precautions while taking Tizanidine1. Kidney disease
2. Liver disease
3. Low blood pressure or are on medication to treat high blood pressure
4. Birth control pills use
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Tizanidine1. Painful muscle spasm associated with static and functional disorders of the spine
2. Following surgery for disc prolapse/osteoarthritis of the hipInteractions for TizanidineAlcohol & other CNS depressants : CNS effects of tizanidine potentiated.Typical Dosage for TizanidineOral-
Adult-
Muscle spasm - 2 mg thrice a day.
Spasticity- Initial dose 6 mg/day in 3 divided doses, then increase stepwise to 12-36 mg/day.
Schedule of TizanidineN/AStorage Requirements for TizanidineStore at room temperature away from moisture and heat.Effects of Missed Dosage of TizanidineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TizanidineGive symptomatic and supportive treatment.Mefenamic Acid
About Mefenamic AcidNSAID, Analgesic,antiinflammatory.Mechanism of Action of Mefenamic AcidMefenamic acid has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other analgesics. Mefenamic acid inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions.Pharmacokinets of Mefenamic AcidAbsorption: Mefenamic acid is well absorbed after oral administration. Distribution: It is distributed in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Mefenamic acid and its metabolites are excreted mainly in the urine.Onset of Action for Mefenamic Acid1-2 hours.Duration of Action for Mefenamic Acid6 hours.Half Life of Mefenamic Acid2-4 hours.Side Effects of Mefenamic Acid1.Nausea
2.Vomiting
3.Anorexia
4.Diarrhoea
5.Gastrointestinal bleeding
6.Abdominal distress
7.Constipation
8.Peptic ulcer
9.Dyspepsia
10.Headache
11.Flatulence
12.Drowsiness
13.Insomnia
14.Agranulocytosis
15.Aplastic anaemia
16.Thrombocytopenia
17.Dizziness
18.Rash
Contra-indications of Mefenamic Acid1.Hypersensitivity to Mefenamic acid and other NSAIDs
2.Inflammatory bowel disease
3.Peptic ulcer
Special Precautions while taking Mefenamic Acid1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Gastrointestinal diseases
5.Pre existing asthma
6.Patient on anticoagulant therapy
7.Heart failure
8.Myocardial infarction
9.StrokePregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationBelow 14 years: contraindicated
NEONATES: used only to close the patent ductus arteriosus as IV form only
Indications for Mefenamic Acid1.Muscular aches
2.Primary Dysmenorrhoea
3.Headaches
4.Acute gout
5.Dental pain
6.Patent ductus arteriosus
Interactions for Mefenamic AcidN/ATypical Dosage for Mefenamic AcidAdult: initial dose: 500 mg followed by 250 mg every 6 hours. Treatment is continued maximum up to 1 week.
Children above 14 years:
500 mg followed by 250 mg every 6 hours. Treatment is continued maximum up to 1 week.
Children below 14 years: not recommended.
Schedule of Mefenamic AcidHStorage Requirements for Mefenamic AcidStore Mefenamic acid at room temperature in a tightly closed light resistant container.Effects of Missed Dosage of Mefenamic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Mefenamic AcidGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.
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