Ibuprofen + Tizanidine Pharmacology

Ibuprofen + Tizanidine

About Ibuprofen + Tizanidine
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Mechanism of Action of Ibuprofen + Tizanidine
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Pharmacokinets of Ibuprofen + Tizanidine
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Onset of Action for Ibuprofen + Tizanidine
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Duration of Action for Ibuprofen + Tizanidine
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Half Life of Ibuprofen + Tizanidine
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Side Effects of Ibuprofen + Tizanidine
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Contra-indications of Ibuprofen + Tizanidine
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Special Precautions while taking Ibuprofen + Tizanidine
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Ibuprofen + Tizanidine
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Interactions for Ibuprofen + Tizanidine
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Typical Dosage for Ibuprofen + Tizanidine
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Schedule of Ibuprofen + Tizanidine
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Storage Requirements for Ibuprofen + Tizanidine
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Effects of Missed Dosage of Ibuprofen + Tizanidine
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Effects of Overdose of Ibuprofen + Tizanidine
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Ibuprofen

About Ibuprofen
NSAID, a propionic acid derivative, Analgesic and anti-inflammatory.
Mechanism of Action of Ibuprofen
Ibuprofen has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other algesics. Ibuprofen inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions. It also inhibits platelet aggregation and prolongs bleeding time.
Pharmacokinets of Ibuprofen
Absorption: Ibuprofen is rapidly absorbed after oral administration. Distribution: It is distributed in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Ibuprofen and its metabolites are excreted mainly in the urine and some amount in bile.
Onset of Action for Ibuprofen
? hours
Duration of Action for Ibuprofen
4-6 hours.
Half Life of Ibuprofen
2 hours
Side Effects of Ibuprofen
1.Nausea
2.Vomiting
3.Diarrhoea
4.Gastrointestinal bleeding
5.Abdominal distress
6.Constipation
7.Peptic ulcer
8.Dyspepsia
9.Headache
10.Drowsiness
11.Blurring of vision
12.Tinnitus
13.Depression
14.Thrombocytopenia
15.Rash
16.Pruritis

Contra-indications of Ibuprofen
1.Hypersensitivity to Ibuprofen and other NSAIDs
2.Peptic ulcer
Special Precautions while taking Ibuprofen
1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Gastrointestinal diseases
5.Pre existing asthma
6.Bleeding disorders
7.Phenylketonuria
8.Oedema
9.Heart failure
10.Myocardial infarction
11.Stroke
Pregnancy Related Information
Use with caution
PREGNANCY in third trimester: contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
CHILDREN below 6 months: contraindicated
Indications for Ibuprofen
1.Rheumatoid arthritis
2.Ankylosing spondylitis
3.Acute gout
4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
5.Osteoarthritis
6.For the relief of fever, pain and inflammation in dental, minor surgery and orthopedic
7.Dysmenorrhoea
8.Juvenile arthritis
9.Migraine
10.Patent ductus arteriosus(IV)
Interactions for Ibuprofen
N/A
Typical Dosage for Ibuprofen
Adult: 1.2 g / day in3 divided doses
Arthritis, gout and dental pain: 300 - 800 mg 3 times daily dose can be increased if needed.
Maximum dose: 3200 mg / day
Pain, Dysmenorrhoea: 1600 - 2400 mg / day in 4 - 6 divided doses
Fever: 600 mg / day in 3 divided doses.
Maximum dose: 1200 mg / day
For migraine: 400 -800 mg 3 times daily
Children: 15- 20 mg / kg body weight / day in 3 - 4 divided doses
Maximum dose: 40 mg / kg body weight / day

Schedule of Ibuprofen
H
Storage Requirements for Ibuprofen
Store Ibuprofen at 15-30 degree C in a tightly closed light resistant container.
Effects of Missed Dosage of Ibuprofen
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ibuprofen
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Excretion of the drug can be enhanced by administration of alkaline diuretics.

Tizanidine

About Tizanidine
A centrally acting a-2 adrenergic agonist, Centrally acting muscle relaxant (short-acting).
Mechanism of Action of Tizanidine
This drug is a centrally acting alpha2 agonist at alpha2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. This results the blocking of nerve impulses (or pain sensations) that are sent to your brain.
Pharmacokinets of Tizanidine
Absorption- Completely absorbed after oral administration.
Distribution- Widely distributed throughout the body. 30% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites.
Excretion- Excreted through urine.
Onset of Action for Tizanidine
1 to 2 hrs after oral administration
Duration of Action for Tizanidine
N/A
Half Life of Tizanidine
N/A
Side Effects of Tizanidine
1. Dizziness
2. Upset stomach
3. Vomiting
4. Tingling sensation in the arms, legs, hands, and feet
5. Dry mouth
6. Increased muscle spasms
7. Yellowing of the skin or eyes
8. Unexplained flu-like symptoms
Contra-indications of Tizanidine
1. Contraindicated in patients with hypersensitivity to the drug or any ingredients of it
Special Precautions while taking Tizanidine
1. Kidney disease
2. Liver disease
3. Low blood pressure or are on medication to treat high blood pressure
4. Birth control pills use
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Tizanidine
1. Painful muscle spasm associated with static and functional disorders of the spine
2. Following surgery for disc prolapse/osteoarthritis of the hip
Interactions for Tizanidine
Alcohol & other CNS depressants : CNS effects of tizanidine potentiated.
Typical Dosage for Tizanidine
Oral-
Adult-
Muscle spasm - 2 mg thrice a day.
Spasticity- Initial dose 6 mg/day in 3 divided doses, then increase stepwise to 12-36 mg/day.
Schedule of Tizanidine
N/A
Storage Requirements for Tizanidine
Store at room temperature away from moisture and heat.
Effects of Missed Dosage of Tizanidine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tizanidine
Give symptomatic and supportive treatment.

Home Delivery for Ibuprofen + Tizanidine in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ibuprofen + tizanidine and other medicines and health products. Home delivery services for ibuprofen + tizanidine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ibuprofen + tizanidine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ibuprofen + tizanidine before they complete the sale. You can get this information while placing the order for ibuprofen + tizanidine with the pharmacy.

Ibuprofen + Tizanidine is a generic medicine name and there are several brands available for it. Some of the brands for ibuprofen + tizanidine might be better known than ibuprofen + tizanidine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ibuprofen + tizanidine in stock, you can ask for one of the branded alternatives for ibuprofen + tizanidine.