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- Pharmacology For Paracetamol + Pheniramine Maleate
Paracetamol + Pheniramine Maleate Pharmacology
Paracetamol + Pheniramine Maleate
About Paracetamol + Pheniramine MaleateN/AMechanism of Action of Paracetamol + Pheniramine MaleateN/APharmacokinets of Paracetamol + Pheniramine MaleateN/AOnset of Action for Paracetamol + Pheniramine MaleateN/ADuration of Action for Paracetamol + Pheniramine MaleateN/AHalf Life of Paracetamol + Pheniramine MaleateN/ASide Effects of Paracetamol + Pheniramine MaleateN/AContra-indications of Paracetamol + Pheniramine MaleateN/ASpecial Precautions while taking Paracetamol + Pheniramine MaleateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Paracetamol + Pheniramine MaleateN/AInteractions for Paracetamol + Pheniramine MaleateN/ATypical Dosage for Paracetamol + Pheniramine MaleateN/ASchedule of Paracetamol + Pheniramine MaleateN/AStorage Requirements for Paracetamol + Pheniramine MaleateN/AEffects of Missed Dosage of Paracetamol + Pheniramine MaleateN/AEffects of Overdose of Paracetamol + Pheniramine MaleateN/AParacetamol
About ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Pheniramine Maleate
About Pheniramine MaleateFirst generation HistamineH1 antagonist ,Alkylamine derivative, Anti histamine.Mechanism of Action of Pheniramine MaleateThis alkyl amine derivative has peripheral H1 receptor antagonist action and compete with histamine for binding to the receptors present on bronchi, uterus etc. This inhibits the activation of receptors and corresponding allergic symptoms produced by it. Centrally the drug also has some antimuscarinic activity.Pharmacokinets of Pheniramine MaleateN/AOnset of Action for Pheniramine MaleateN/ADuration of Action for Pheniramine MaleateN/AHalf Life of Pheniramine Maleate19 hrsSide Effects of Pheniramine Maleate1. Drowsiness
2. Nervousness
3. Irritability
4. Incoordination
5. Lack of concentration
6. Dizziness
7. Tinnitus
8. Nausea
9. Vomiting
10. Difficulty in passing urine
11. Asthma
12. Wheezing
13. Swelling of the face lips or tongue
14. Hives
15. Itching
16. Skin rash
17. Fainting
Contra-indications of Pheniramine Maleate1. Hypersensitivity to the drug or its ingredients
2. Porphyria
Special Precautions while taking Pheniramine Maleate1. Heart disease
2. High blood pressure
3. Narrow angle glaucoma
4. Enlarged prostate gland
5. Any work which require mental alertness
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES: Contraindicated
Indications for Pheniramine Maleate1. Eczema
2. Dermatitis
3. Urticaria
4. Skin oedema
5. Itching due to insect bites
6. Photo-dermatitis
7. Rhinitis
8. Serum sickness
9. Paresis during pregnancy
10. Toxaemia and retention of placenta
11. Motion sickness
Interactions for Pheniramine MaleateAlcohol and other CNS depressants (Hypnotics, Sedative, Tranquilizers, Antianxiety agents, Narcotic analgesics): Additive effect leading to profound CNS depression.
MAOIs: Prolong anticholinergic (drying) effects.
Anticholinergics (some) & Tricyclic Antidepressants: May have enhanced effect.
Aminoglycosides: Ototoxicity of aminoglycosides masked.Typical Dosage for Pheniramine MaleateOral
Adult:15-30 mg 2 - 3 times daily.
Schedule of Pheniramine MaleateGStorage Requirements for Pheniramine MaleateStored at controlled room temperature. Protect from light and excessive heat. Keep out of reach of children.Effects of Missed Dosage of Pheniramine MaleateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Pheniramine MaleateGive symptomatic and supportive treatmentHome Delivery for Paracetamol + Pheniramine Maleate in Your City
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Paracetamol + Pheniramine Maleate is a generic medicine name and there are several brands available for it. Some of the brands for paracetamol + pheniramine maleate might be better known than paracetamol + pheniramine maleate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have paracetamol + pheniramine maleate in stock, you can ask for one of the branded alternatives for paracetamol + pheniramine maleate.