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- Pharmacology For Carisoprodol + Paracetamol
Carisoprodol + Paracetamol Pharmacology
Carisoprodol + Paracetamol
About Carisoprodol + ParacetamolN/AMechanism of Action of Carisoprodol + ParacetamolN/APharmacokinets of Carisoprodol + ParacetamolN/AOnset of Action for Carisoprodol + ParacetamolN/ADuration of Action for Carisoprodol + ParacetamolN/AHalf Life of Carisoprodol + ParacetamolN/ASide Effects of Carisoprodol + ParacetamolN/AContra-indications of Carisoprodol + ParacetamolN/ASpecial Precautions while taking Carisoprodol + ParacetamolN/APregnancy Related InformationContraindicated; since Carisoprodol is contraindicated in pregnancy. So the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Carisoprodol is contraindicated in breast feeding. So the combination generic cannot be used in breast feeding mother.Children Related InformationN/AIndications for Carisoprodol + Paracetamol1,Muscle relaxant
2.Topical analgesic
Interactions for Carisoprodol + ParacetamolN/ATypical Dosage for Carisoprodol + Paracetamol1 tablet to be taken 3 times daily.Schedule of Carisoprodol + ParacetamolN/AStorage Requirements for Carisoprodol + ParacetamolN/AEffects of Missed Dosage of Carisoprodol + ParacetamolN/AEffects of Overdose of Carisoprodol + ParacetamolN/ACarisoprodol
About CarisoprodolCentrally-acting skeletal muscle relaxant, antipyretic and weak antiadrenergic, Muscle relaxant.Mechanism of Action of CarisoprodolThis centrally acting drug blocks pain sensations between the nerves and the brain. It produces muscle relaxation by blocking interneuronal activity and depressing transmission of polysynaptic neurons in the descending reticular formation and spinal cord. This decreases muscular spasms. It also has antipyretic and weak antiadrenergic activity.Pharmacokinets of CarisoprodolAbsorption- Rapidly absorbed after oral administration
Distribution- Widely distributed into CNS. 60% bound to the plasma proteins
Metabolism- It is metabolized in the liver to its metabolites by dealkylation and hydroxylation. Meprobamate is its active metabolite
Excretion- It is excreted through urine
Onset of Action for Carisoprodol30 minuteDuration of Action for Carisoprodol2-6 hoursHalf Life of CarisoprodolIts plasma half life is 8 hoursSide Effects of Carisoprodol1. Paralysis.
2. Weakness.
3. Light-headed.
4. Fainting.
5. Fast heartbeat.
6. Seizure (convulsions).
7. Vision loss.
8. Agitation.
9. Confusion.
10. Drowsiness.
11. Dizziness.
12. Tremor.
13. Headache.
14. Depression.
15. Feeling irritable.
16. Blurred vision.
17. Sleep problems.
18. Nausea.
19. Vomiting.
20. Hiccups.
21. Upset stomach.
Contra-indications of Carisoprodol1. Hypersensitivity to the drug.
2. Epilepsy or other seizure disorder.
3. Liver disease.
4. Kidney disease.
Special Precautions while taking Carisoprodol1. Alcohol abuse.
2. CNS depressants therapy.
3. Impairment of hepatic function.
4. Renal impairment.
5. Any work which require mental alertness such as driving or operating machine
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated.Children Related InformationUse with cautionIndications for CarisoprodolMusculo-skeletal relaxantInteractions for CarisoprodolAlcohol, other CNS depressants or Psychotropic drugs: Additive actions with concurrent use, exercise caution if more than one of these agents used concomitantly.Typical Dosage for CarisoprodolOral-
Adults - 350 mg thrice daily
Elderly -125 mg thrice daily
Schedule of CarisoprodolHStorage Requirements for CarisoprodolStore at controlled room temperature 20 to 25? C (68 to 77? F)Effects of Missed Dosage of CarisoprodolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CarisoprodolGive symptomatic and supportive treatment. Induce emesis or gastric lavage. Monitor urine output and vital signs regularlyParacetamol
About ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Home Delivery for Carisoprodol + Paracetamol in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for carisoprodol + paracetamol and other medicines and health products. Home delivery services for carisoprodol + paracetamol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take carisoprodol + paracetamol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for carisoprodol + paracetamol before they complete the sale. You can get this information while placing the order for carisoprodol + paracetamol with the pharmacy.
Carisoprodol + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for carisoprodol + paracetamol might be better known than carisoprodol + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have carisoprodol + paracetamol in stock, you can ask for one of the branded alternatives for carisoprodol + paracetamol.