Chlorzoxazone Pharmacology

Chlorzoxazone

About Chlorzoxazone
A benzoxazolone derivative, Centrally acting Muscle relaxant and mild sedative.
Mechanism of Action of Chlorzoxazone
This muscle relaxant works by blocking nerve impulses (or pain sensations) that are sent to your brain. It inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. It may also reduce the release of inflammatory leukotrienes. Chlorzoxazone may act by inhibiting calcium influx.
Pharmacokinets of Chlorzoxazone
Absorption- Rapidly and completely absorbed after oral administration.
Distribution- Widely distributed in the body.
Metabolism- It is metabolized in the liver to its metabolites by glucoronide conjugation.
Excretion- It is excreted through urine.
Onset of Action for Chlorzoxazone
1 hr after oral administration
Duration of Action for Chlorzoxazone
3 to 4 hrs
Half Life of Chlorzoxazone
N/A
Side Effects of Chlorzoxazone
1. Difficulty breathing
2. Closing of your throat
3. Swelling of your lips, tongue, or face
4. Liver damage
5. Yellowing of the skin or eyes
5. Nausea
6. Abdominal pain or discomfort
7. Unusual bleeding or bruising
8. Severe fatigue
9. Stomach damage
10. Drowsiness
11. Dizziness
12. Lightheadedness
13. Discolored urine
14. Rash
Contra-indications of Chlorzoxazone
1. Hypersensitivity to the drug
Special Precautions while taking Chlorzoxazone
1. Liver problems
2. Stomach problems
3. Intestinal problems
4. Any drug allergies
5. Any work which require mental alertness such as driving and machines operating
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Chlorzoxazone
1. Painful skeletal muscle spasms
Interactions for Chlorzoxazone
Alcohol or other CNS depressants: Additive effect if used concomitantly.
Typical Dosage for Chlorzoxazone
Adults: 250 mg-750 mg 3-4 times daily.
Children: 125 mg -500 mg 3-4 times daily.
Schedule of Chlorzoxazone
H
Storage Requirements for Chlorzoxazone
Store at room temperature away from moisture and heat.
Effects of Missed Dosage of Chlorzoxazone
Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.
Effects of Overdose of Chlorzoxazone
Give symptomatic and supportive treatment. Induce emesis or gastric lavage. Administer activated charcoal to avoid further absorption of drug.

Home Delivery for Chlorzoxazone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including chlorzoxazone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for chlorzoxazone and other medicines and health products. Home delivery services for chlorzoxazone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take chlorzoxazone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for chlorzoxazone before they complete the sale. You can get this information while placing the order for chlorzoxazone with the pharmacy.

Chlorzoxazone is a generic medicine name and there are several brands available for it. Some of the brands for chlorzoxazone might be better known than chlorzoxazone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have chlorzoxazone in stock, you can ask for one of the branded alternatives for chlorzoxazone.