Nimesulide Topical Pharmacology

Nimesulide Topical

About Nimesulide Topical
COX-2 selective NSAID, Analgesic.
Mechanism of Action of Nimesulide Topical
This Non Steroidal Anti Inflammatory Drug reduces prostaglandin synthesis by the inhibition of cyclo oxygenase enzyme2 selectively. This is a weaker inhibition .So it produces weaker analgesic property. Its potent anti-inflammatory activity is due to its action on various stages of inflammation. This leads to the inhibition of super oxide anion formation invitro by activated neutrophil, inhibition of histamine release from tissue mast cells and basophiles. Additionally it also prevents platelet activating factor synthesis and metalloproteinase synthesis thus prevents the breakdown of osteoarthritic human cartilage. It also prevent tumor necrosis factor alpha and thus reduce the formation of cytokines. This drug can activate glucocorticoid receptors in the body.
Pharmacokinets of Nimesulide Topical
Absorption - Slowly absorbed from the skin
Onset of Action for Nimesulide Topical
N/A
Duration of Action for Nimesulide Topical
N/A
Half Life of Nimesulide Topical
N/A
Side Effects of Nimesulide Topical
1. Local irritation
2. Erythema
3. Rash
4. Desquamation
5. Pruritis
6. Skin discoloration
Contra-indications of Nimesulide Topical
Contraindicated in patients with hypersensitivity to the drug
Special Precautions while taking Nimesulide Topical
N/A
Pregnancy Related Information
N/A
Old Age Related Information
Use with caution
Breast Feeding Related Information
N/A
Children Related Information
Use with caution
Indications for Nimesulide Topical
1. Sprains
2. Strains
3. Tendinitis
4. Tenosynovitis
5. Low back pain
6. Post traumatic inflammation and pain
7. Periarthritis
8. Osteoarthritis
9. Morning stiffness
Interactions for Nimesulide Topical
N/A
Typical Dosage for Nimesulide Topical
1. 30g Gel (10mg/g)
2. 20g Gel (1%)
3. 25g Gel (1%w/w)
Drug should be applied with gentle massage only
1g gel applied to the affected site 3 to 4 times daily. Review therapy after 4 weeks
Schedule of Nimesulide Topical
N/A
Storage Requirements for Nimesulide Topical
Store at room temperature. Keep away from excessive heat or direct sunlight. Do not refrigerate. Replace cap tightly.
Effects of Missed Dosage of Nimesulide Topical
Apply the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and apply only the next regularly scheduled dose. Do not apply a double dose of this medication.
Effects of Overdose of Nimesulide Topical
Give symptomatic and supportive treatment

Home Delivery for Nimesulide Topical in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including nimesulide topical.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nimesulide topical and other medicines and health products. Home delivery services for nimesulide topical may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take nimesulide topical only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nimesulide topical before they complete the sale. You can get this information while placing the order for nimesulide topical with the pharmacy.

Nimesulide Topical is a generic medicine name and there are several brands available for it. Some of the brands for nimesulide topical might be better known than nimesulide topical itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nimesulide topical in stock, you can ask for one of the branded alternatives for nimesulide topical.