Infliximab Pharmacology

Infliximab

About Infliximab
Tumor Necrosis Factor (TNF) Blocking Agent, Monoclonal Antibody, Immunosuppressant,Disease-modifying Antirheumatic Drug.
Mechanism of Action of Infliximab
Infliximab is a type of monoclonal antibody. It works by suppressing part of the immune system and modifying the process of inflammation. Infliximab binds to human necrosis factor alpha an inducer of proinflammatory cytokines (IL-1 and IL-6).TNF alpha also enhances leukocyte migration activates neutrophils and induces acute phase reactants. It reduces infiltration of inflammatory cells and TNF production in inflamed areas of intestine. Infliximab is used for treating the inflammation of Crohn`s disease, rheumatoid arthritis. In Crohn`s disease treatment with Infliximab reduces the movement of inflammatory cells into inflamed areas of the intestines.
Pharmacokinets of Infliximab
Absorption:It is completely absorbed after parenteral administration
Onset of Action for Infliximab
N/A
Duration of Action for Infliximab
N/A
Half Life of Infliximab
N/A
Side Effects of Infliximab
1.Headache
2.Nausea
3.Upper respiratory infection
4.Abdominal pain
5.Fever
6.Rash
7.Vomiting
8.Urticaria
9.Dyspnoea
10.Hypotension
11.Dizziness
12.Flushing
13.Diarrhea
14.Constipation
15.Increased sweating
16.Fatigue
17.Chest pain
18.Depression
19.Confusion
20.Agitation



Contra-indications of Infliximab
1.Hypersensitivity to Infliximab
2.Tuberculosis
3.Abscesses
4.Sepsis
5.Opportunistic infections
6.Heart failure
Special Precautions while taking Infliximab

1.Liver impairment
2.Hepatitis B
3.Renal impairment
4.Dormant tuberculosis infection
5.Multiple sclerosis
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Infliximab
1.Crohn`s disease
2.Enterocutaneous chron`s fistula
3.Rheumatoid arthritis
Interactions for Infliximab
N/A
Typical Dosage for Infliximab
5mg/kg over 2hours and repeat the dose 2nd and 6th weeks and then at further intervals of 6-8 weeks, depending on the condition treated and the response to the first doses.
Schedule of Infliximab
N/A
Storage Requirements for Infliximab
Store at a temperature range of 2 to 8 degree C. Avoid freezing
Effects of Missed Dosage of Infliximab
The doctor should be informed immediately if a dose is missed
Effects of Overdose of Infliximab
Give supportive measures and symptomatic treatment

Home Delivery for Infliximab in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including infliximab.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for infliximab and other medicines and health products. Home delivery services for infliximab may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take infliximab only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for infliximab before they complete the sale. You can get this information while placing the order for infliximab with the pharmacy.

Infliximab is a generic medicine name and there are several brands available for it. Some of the brands for infliximab might be better known than infliximab itself. If the pharmacy that's willing to deliver medicines to your home doesn't have infliximab in stock, you can ask for one of the branded alternatives for infliximab.